CpG Methylation Inactivates the Transcriptional Activity of the Promoter of the Humanp53Tumor Suppressor Gene

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

DNA methylation and cancer

1994 • 418 citations

DNA methylation errors and cancer.

1996 • 405 citations

Carcinogenic Nickel Silences Gene Expression by Chromatin Condensation and DNA Methylation: a New Model for Epigenetic Carcinogens

1995 • 364 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.

1995 • 253 citations

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

1996 • 237 citations

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1995 • 220 citations

Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure.

1996 • 165 citations

Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer.

1994 • 147 citations

The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element.

1985 • 146 citations

Methylation of the 5' CpG island of the endothelin B receptor gene is common in human prostate cancer.

1997 • 143 citations

Characterization of the human p53 gene promoter.

1989 • 108 citations

Identification of a Novel p53 Promoter Element Involved in Genotoxic Stress-Inducible p53 Gene Expression

1995 • 106 citations

Mechanisms for the involvement of DNA methylation in colon carcinogenesis.

1996 • 106 citations

1995 Deichmann Lecture—p53 tumor suppressor gene: At the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment

1995 • 55 citations

Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation

1995 • 42 citations