Pamidronate

Biochemical Evaluation of Patients with Cancer-Associated Hypercalcemia

1980 • 715 citations

New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.

1980 • 658 citations

The acute-phase response after bisphosphonate administration

1987 • 354 citations

Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix.

1986 • 347 citations

PREVENTION OF STEROID-INDUCED OSTEOPOROSIS WITH (3-AMINO-1-HYDROXYPROPYLIDENE)-1, 1-BISPHOSPHONATE (APD)

1988 • 342 citations

Cancer-Associated Hypercalcemia: Morbidity and Mortality

1990 • 341 citations

The hypercalcemia of malignancy: Pathogenesis and management

1982 • 317 citations

Structure-activity relationships of various bisphosphonates

1983 • 310 citations

Skeletal Renewal and Metabolic Bone Disease

1969 • 280 citations

TREATMENT OF PAGET'S DISEASE WITH (3-AMINO-1-HYDROXYPROPYLIDENE)-1, 1-BISPHOSPHONATE (A.P.D.)

1979 • 257 citations

REDUCED MORBIDITY FROM SKELETAL METASTASES IN BREAST CANCER PATIENTS DURING LONG-TERM BISPHOSPHONATE (APD) TREATMENT

1987 • 206 citations

COMPARISON OF THREE INTRAVENOUS BISPHOSPHONATES IN CANCER-ASSOCIATED HYPERCALCAEMIA

1989 • 199 citations

Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: The effect of a bisphosphonate

1988 • 191 citations

COMPARISON OF AMINOHYDROXYPROPYLIDENE DIPHOSPHONATE, MITHRAMYCIN, AND CORTICOSTEROIDSICALCITONIN IN TREATMENT OF CANCER-ASSOCIATED HYPERCALCAEMIA

1985 • 190 citations

Clinical Evaluation of Bone Turnover by Serum Osteocalcin Measurements in a Hospital Setting*

1984 • 185 citations

Paget's disease of bone: early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD).

1987 • 183 citations

Comparative study of available medical therapy for hypercalcemia of malignancy

1983 • 167 citations

Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats

1980 • 164 citations

Resorbing bone is chemotactic for monocytes

1978 • 160 citations

The actions of parathyroid hormone on bone: Relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases

1976 • 156 citations

Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD

1989 • 148 citations

Pyrophosphate and Diphosphonates in Skeletal Metabolism

1975 • 140 citations

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

1987 • 140 citations

COMPARISON OF INTRAVENOUS (3-AMINO-1-HYDROXYPROPYLIDENE)-1, 1-BISPHOSPHONATE AND VOLUME REPLETION IN TUMOUR-INDUCED HYPERCALCAEMIA

1983 • 138 citations

Leukaemia and residence near electricity transmission equipment: a case-control study

1989 • 137 citations

Apd in paget's disease of bone role of the mononuclear phagocyte system?

1980 • 133 citations

Treatment of bone metastases from breast cancer with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

1988 • 132 citations

Musculoskeletal manifestations of paget's disease of bone

1980 • 129 citations

Differential Action of the Bisphosphonates (3-Amino-1-Hydroxypropylidene)-1,1-Bisphosphonate (APD) and Disodium Dichloromethylidene Bisphosphonate (Cl2MDP) on Rat Macrophage-mediated Bone Resorption In Vitro

1982 • 121 citations

Rehydration in the Treatment of Severe Hypercalcaemia

1981 • 120 citations

Rheumatic manifestations of Paget's disease of bone

1974 • 118 citations

Assessment of response of bone metastases to systemic treatment in patients with breast cancer

1983 • 108 citations

Dose-response in the treatment of hypercalcemia of malignancy by a single infusion of the bisphosphonate AHPrBP.

1988 • 104 citations

A single infusion of the bisphosphonate AHPrBP (APD) as treatment of Paget's disease of bone

1988 • 103 citations

Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group.

1987 • 103 citations

Mechanism of malignant hypercalcaemia in carcinoma of the breast.

1985 • 99 citations

Sclerosis of lytic bone metastases after disodium aminohydroxypropylidene bisphosphonate (APD) in patients with breast carcinoma.

1988 • 92 citations

Efficacious Management with Aminobisphosphonate (APD) in Paget??s Disease of Bone

1987 • 91 citations

Serum bone GLA-protein is not a sensitive marker of bone turnover in Paget's disease of bone

1986 • 87 citations

Characteristics and Bisphosphonate Treatment of a Patient with Juvenile Osteoporosis

1985 • 83 citations

PARATHYROID HORMONE‐RELATED PROTEIN IN HYPERCALCAEMIA OF MALIGNANCY

1989 • 83 citations

Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia in malignancy.

1984 • 83 citations

Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma

1985 • 80 citations

Hypercalcaemia of Malignancy: Evidence for a Non-Parathyroid Humoral Agent with An Effect on Renal Tubular Handling of Calcium

1984 • 78 citations

Uptake by Bone of Pyrophosphate, Diphosphonates and their Technetium Derivatives

1978 • 77 citations

Inhibition by diphosphonates of bone resorption induced by the walker tumor of the rat

1985 • 77 citations

Treatment of malignancy-associated hypercalcemia with intravenous aminohydroxypropylidene diphosphonate.

1986 • 76 citations

Treatment of Paget's disease of bone with intravenous 4-amino-1-hydroxybutylidene-1,1-bisphosphonate

1986 • 75 citations

Skeletal Renewal and Metabolic Bone Disease

1969 • 73 citations

Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis.

1989 • 72 citations

The effects of hydrocortisone, parathyroid hormone and the bisphosphonate, APD, on bone resorption in neonatal mouse calvaria

1986 • 71 citations

Assay of 1-hydroxy-3-aminopropylidene-1,1-bisphosphonate and related bisphosphonates in human urine and plasma by high-performance ion chromatography

1989 • 71 citations

Treatment of cancer associated hypercalcaemia with combined aminohydroxypropylidene diphosphonate and calcitonin.

1986 • 68 citations

Efficacy of amino-hydroxypropylidene bisphosphonate in hypercalcemia: Observations on regulation of serum calcium

1982 • 68 citations

Osteolytic bone metastases in breast carcinoma pathogenesis, morbidity and biphosphonate treatment

1986 • 66 citations

Calcium metabolism in cancer.Studies using calcium isotopes and immunoassays for parathyroid hormone and calcitonin

1976 • 65 citations

Low dose intravenous 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) for the treatment of Paget's disease of bone.

1986 • 64 citations

Relation Between Signs and Symptoms in Paget's Disease of Bone

1986 • 64 citations

A single-day treatment of tumor-induced hypercalcemia by intravenous amino-hydroxypropylidene bisphosphonate

1986 • 63 citations

Single dose versus daily intravenous aminohydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy

1988 • 62 citations

THE PATHOGENESIS OF HUMORAL HYPERCALCAEMIA OF MALIGNANCY

1987 • 61 citations

Effects of decreasing serum calcium on circulating parathyroid hormone and vitamin D metabolites in normocalcaemic and hypercalcaemic patients treated with APD.

1986 • 61 citations

Review of Fracture Experience During Treatment of Paget??s Disease of Bone with Etidronate Disodium (EHDP)

1983 • 60 citations

Dose/response study of aminohydroxypropylidene bisphosphonate in tumor-associated hypercalcemia

1987 • 60 citations

Serum Osteocalcin In Paget's Disease of Bone: Basal Concentrations and Response to Bisphosphonate Treatment

1987 • 60 citations

Determination of the bisphosphonate pamidronate disodium in urine by pre-column derivatization with fluorescamine, high-performance liquid chromatography and fluorescence detection

1989 • 59 citations

Clinical and biological effects of low doses of (3 amino‐1 hydroxypropylidene)‐1,1‐bisphosphonate (APD) in Paget's disease of bone

1982 • 54 citations

Diphosphonates inhibit human osteoblast secretion and proliferation

1989 • 53 citations

Response to retreatment of malignant hypercalcemia with the bisphosphonate AHPrBP (APD): Respective role of kidney and bone

1990 • 52 citations

Regulation of calcium absorption by 1,25,dihydroxy-vitamin D—Studies of the effects of a bisphosphonate treatment

1982 • 51 citations

In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation.

1982 • 51 citations

3(Amino-1,1-hydroxypropylidene) bisphosphonate (APD) for hypercalcaemia of breast cancer

1987 • 51 citations

Aminohydroxypropylidene bisphosphonate (APD) treatment for tumor-associated hypercalcemia: A randomized comparison between a 3-day treatment and single 24-hour infusions

1989 • 50 citations

Is APD a Promising Drug in the Treatment of Severe Osteogenesis Imperfecta?

1988 • 49 citations

Untreated Paget disease of bone studied by scintigraphy.

1984 • 48 citations

Immobilization-related hypercalcaemia—a possible novel mechanism and response to pamidronate

1990 • 48 citations

Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat

1986 • 46 citations

Prevention of steroid-induced osteoporosis with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

1988 • 45 citations

Radiological assessment of Paget's disease of bone after treatment with the bisphosphonates EHDP and APD

1987 • 44 citations

Advances in the Management of Paget??s Disease of Bone

1990 • 44 citations

Effect of single high dose infusions of aminohydroxypropylidene diphosphonate on hypercalcaemia caused by cancer.

1987 • 43 citations

Bone loss and bone blood flow in paraplegic rats treated with calcitonin, diphosphonate, and indomethacin

1988 • 43 citations

Side effects of disodium aminohydroxypropylidenediphosphonate (APD) during treatment of bone diseases.

1984 • 43 citations

Clinical Experience with Aminohydroxypropylidene Bisphosphonate (APD) in the Management of Cancer-associated Hypercalcaemia

1988 • 43 citations

Fast and Effective Treatment of Malignant Hypercalcemia

1990 • 41 citations

EFFECTIVE ORAL TREATMENT OF SEVERE PAGET'S DISEASE OF BONE WITH APD (3‐AMINO‐I‐HYDROXYPROPYLIDENE‐1,1‐BISPHOSPHONATE); A COMPARISON WITH COMBINED CALCITONIN + EHDP (1 ‐HYDROXYETHYLIDENE‐1,1 ‐BISPHOSPHONATE)

1984 • 38 citations

Oral versus intravenous AHPrBP (APD) in the treatment of hypercalcemia of malignancy

1986 • 37 citations

AMINOPROPYLIDINE DIPHOSPHONATE (APD) IN MILD PRIMARY HYPERPARATHYROIDISM: EFFECT ON CLINICAL STATUS

1990 • 36 citations

Efficacy of the bisphosphonate APD∗∗(Note on the nomenclature: Traditional abbreviations for identifying compounds have been used in the text. According to IUPAC: Nomenclature of Organic Chemistry, Sections A-H (Pergamon Press, Oxford, 1979), the new abbreviations are as follows: APD = AHP1BP: 3-amino-1-hydroxypropylidene-1,1-bisphosphonate EHDP = HEBP: 1-hydroxyethylidene-1,1-bisphosphonate Cl2MDP = Cl2MBP: Dichloromethylenebisphosphonate. in the control of Paget's bone disease

1985 • 35 citations

RENAL PHOSPHATE THRESHOLD AND RESPONSE TO PAMIDRONATE IN HUMORAL HYPERCALCAEMIA OF MALIGNANCY

1989 • 35 citations

Paget's disease of bone treated in five days with AHPrBP (APD) per Os

1987 • 34 citations

Fast (4-h) or slow (24-h) infusions of pamidronate disodium (aminohydroxypropylidene diphosphonate (APD)) as single shot treatment of hypercalcaemia

1990 • 34 citations

Paget??s Disease of Bone An Update on Management

1985 • 34 citations

A COMPARISON OF SINGLE AND MULTIPLE INTRAVENOUS INFUSIONS OF 3‐AMINO‐1‐HYDROXYPROPYLIDENE‐1, 1‐BISPHOSPHONATE (APD) IN THE TREATMENT OF HYPERCALCEMIA OF MALIGNANCY

1987 • 33 citations

Distribution of 3-amino-1-hydroxypropane-1,1-diphosphonic acid in rats and effects on rat osteosarcoma.

1985 • 33 citations

Quantitative bone scintigraphy in Paget's disease treated with APD

1985 • 33 citations

Reduction in calcium excretion in women with breast cancer and bone metastases using the oral bisphosphonate pamidronate

1990 • 32 citations

Apposition and resorption of bone during oral treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

1983 • 31 citations

Hypercalcaemia due to sarcoidosis corrects with bisphosphonate treatment

1986 • 30 citations

Clinical experience with the use of two diphosphonates in the treatment of Paget's disease.

1985 • 30 citations

A New Diphosphonate: Dissociation Between Effects on Cells and Mineral in Rats and a Preliminary Trial in Paget’s Disease

1978 • 25 citations

Comparison of different dose regimes of aminohydroxypropylidene‐1,1‐ bisphosphonate (APD) in hypercalcaemia of malignancy.

1989 • 25 citations

Orthopedic aspects of paget's disease of bone

1980 • 25 citations

Immobilization hypercalcaemia responding to intravenous pamidronate sodium therapy

1989 • 24 citations

Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy

1989 • 24 citations

Malignancy-associated hypercalcaemia: relationship between mechanisms of hypercalcaemia and response to antihypercalcaemic therapy.

1987 • 24 citations

Use of aminohydroxypropylidene bisphosphonate (AHPrBP, "APD") for the treatment of hypercalcemia in patients with renal impairment.

1990 • 19 citations

AMINOHYDROXYPROPYLIDENE DIPHOSPHONATE TREATMENT OF HYPERCALCEMIC CRISIS DUE TO PRIMARY HYPERPARATHYROIDISM

1987 • 17 citations

One-shot high-dose pamidronate disodium (APD): effective, simple treatment for hypercalcaemia in haematological malignancy

1989 • 15 citations

Single high-dose (45 mg) infusions of aminohydroxypropylidene diphosphonate for severe malignant hypercalcemia

1989 • 15 citations

A comparison of the pharmacokinetics of 14C-labelled APD and 99mTc-labelled APD in the mouse

1988 • 15 citations

COMPARISON OF INTESTINAL CALCIUM ABSORPTION AND CIRCULATING 1,25‐DIHYDROXYVITAMIN D LEVELS IN MALIGNANCY‐ASSOCIATED HYPERCALCAEMIA AND PRIMARY HYPERPARATHYROIDISM

1987 • 13 citations

Humoral Hypercalcaemia of Malignancy: Metabolic and Histomorphometric Studies During Surgical Management of the Primary Tumour

1986 • 11 citations

Uptake and localization of99mTc-methylene diphosphonate in mouse osteosarcoma

1982 • 11 citations

Radiological demonstration of healing in Paget's disease of bone treated with APD

1985 • 11 citations

Treatment of hypercalcaemia in thyrotoxicosis with aminohydroxypropylidene diphosphonate

1988 • 11 citations

[Simple treatment of tumor-induced hypercalcemia: i.v. aminohydroxypropylidene biphosphonate].

1983 • 8 citations

Treatment of Paget's bone disease with a bisphosphonate.

1984 • 6 citations

Pamidronate Sodium and Calcitonin-Resistant Paget's Disease

1989 • 5 citations

Successful treatment of persistent posttransplant hyperparathyroidism with diphosphonate.

1986 • 3 citations

[Amino-hydroxy-propylidene biphosphonate in the treatment of Paget's disease resistant to calcitonin and/or etidronate].

1989 • 3 citations