Reactive oxygen species and iron—a dangerous partnership in inflammation

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1978 • 876 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

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1986 • 680 citations

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1985 • 532 citations

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1988 • 408 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

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1986 • 333 citations

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1991 • 307 citations

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1993 • 299 citations

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1985 • 277 citations

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Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation

1989 • 257 citations

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1987 • 235 citations

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1992 • 224 citations

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1989 • 223 citations

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation

1986 • 187 citations

Skin Inflammation: Reactive Oxygen Species and the Role of Iron

1992 • 185 citations

Superoxide dependent iron release from ferritin in inflammatory diseases

1988 • 179 citations

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Metal ions and oxygen radical reactions in human inflammatory joint disease

1985 • 142 citations

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1985 • 127 citations

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1989 • 116 citations

On the limited ability of superoxide to release iron from ferritin

1990 • 114 citations

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1968 • 108 citations

Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study.

1986 • 104 citations

Iron in Immunity: Cancer and Inflammation

1990 • 103 citations

Ferritin and hemosiderin in pathological tissues

1992 • 95 citations

The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide

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The effect of synovial iron on the progression of rheumatoid disease

1984 • 92 citations

Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin

1982 • 90 citations

Microsomal lipid peroxidation: Mechanisms of initiation

1989 • 90 citations

The role of nonenzymatic glycosylation, transition metals, and free radicals in the formation of collagen aggregates

1991 • 86 citations

Overload of iron in the skin of patients with varicose ulcers. Possible contributing role of iron accumulation in progression of the disease.

1988 • 86 citations

Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress.

1990 • 86 citations

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1985 • 78 citations

Studies on the Role of Reactive Oxygen Species in Mediating Lipid Peroxide Formation in Epidermal Microsomes of Rat Skin

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Oxidative damage to lipids within the inflamed human joint provides evidence of radical-mediated hypoxic-reperfusion injury

1991 • 69 citations

Is chronic synovitis an example of reperfusion injury?

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The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin

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The cutaneous porphyrias.

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Iron in joint inflammation.

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1991 • 55 citations

Identification of initiating agents in myoglobin-induced lipid peroxidation

1991 • 53 citations

A pathological role for damaged hyaluronan in synovitis.

1991 • 47 citations

Speciation of non-transferrin-bound iron ions in synovial fluid from patients with rheumatoid arthritis by proton nuclear magnetic resonance spectroscopy

1991 • 45 citations

An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis.

1993 • 36 citations

Iron content in normal and psoriatic epidermis

1973 • 34 citations

The role of iron in an acute model of skin inflammation induced by reactive oxygen species (ROS)

1992 • 30 citations

Haemoglobin and Myoglobin as Inhibitors of Hydroxyl Radical Generation in a Model System of “Iron Redox” Cycle

1989 • 30 citations

Liver Iron Overload and Desferrioxamine Treatment of Porphyria cutanea tarda

1991 • 29 citations

Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch.

1985 • 28 citations

Inactivation of synovial fluid α₁‐antitrypsin by exercise of the inflamed rheumatoid joint

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Protection against free radical formation by protein bound iron

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Localized hemosiderosis as a sequela of acne

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Successful Treatment of Hemodialysis-Related Porphyria cutanea tarda with Deferoxamine

1990 • 21 citations

Effect of iron complexes on adjuvant arthritis in rats.

1992 • 19 citations

Overload of iron in the skin of patients with varicose ulcers. Possible contributing role of iron accumulation in progression of the disease

1988 • 19 citations

The oxidation of cytochrome-c oxidase vesicles by hemoglobin

1994 • 17 citations

Cytoskeletal rearrangement by oxidative stress.

1989 • 15 citations

Immunohistochemical demonstration of ferritin in sweat gland and sweat gland neoplasms

1990 • 11 citations

Ultrastructure of synovial changes in rheumatoid disease and in seronegative inflammatory arthropathies

1983 • 10 citations

Iron Kinetics in the Skin of Patients with Iron Overload

1972 • 8 citations

Oxidative Damage and its Relevance to Inflammatory Joint Disease

2019 • 3 citations