The molecular biology of chronic myeloid leukaemia.

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

1995 • 481 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Identification of the Constant Chromosome Regions Involved in Human Hematologic Malignant Disease

1982 • 309 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

Chromosomal Localization of the Human Homolog (c- sis ) of the Simian Sarcoma Virus onc Gene

1982 • 262 citations

The molecular biology of platelet-derived growth factor

1983 • 252 citations

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

1995 • 224 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

Increased neutrophil respiratory burst in bcr-null mutants

1995 • 193 citations

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

1983 • 172 citations

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.

1983 • 105 citations

The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cells

1995 • 75 citations

Optimization of antisense oligodeoxynucleotide structure for targeting bcr-abl mRNA

1995 • 56 citations

Responsiveness of the in vitro hematopoietic microenvironment to platelet-derived growth factor

1985 • 52 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 47 citations

The Ras signaling pathway and the molecular basis of myeloid leukemogenesis

1995 • 30 citations

The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro

1985 • 23 citations

Undetectable bcr‐abl rearrangements in some CML patients are due to a deletion mutation in the bcr gene

1988 • 19 citations

Chronic myeloid leukaemia and the philadelphia translocation: Do the C-SIS oncogene and platelet-derived growth factor provide the link?

1983 • 18 citations

Philadelphia chromosome-positive leukaemia: the translocated genes and their gene products

1992 • 17 citations

Spatial relationship of chromosomes 9 and 22 at metaphase in patients with chronic myelogenous leukemia (CML)

1988 • 5 citations