Biotransformation of Perchloroethene: Dose-Dependent Excretion of Trichloroacetic Acid, Dichloroacetic Acid, andN-acetyl-S-(trichlorovinyl)-l-Cysteine in Rats and Humans after Inhalation

The pharmacology of dichloroacetate

1989 • 477 citations

Metabolism of trichloroethylene in man

1975 • 174 citations

Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice

1992 • 155 citations

Bioactivation of Nephrotoxic Haloalkenes by Glutathione Conjugation: Formation of Toxic and Mutagenic Intermediates by Cysteine Conjugate β-Lyase

1989 • 151 citations

Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals

1992 • 150 citations

Metabolism of trichloroethylene in man

1974 • 143 citations

Bacterial β-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

1986 • 133 citations

Perchloroethylene-induced rat kidney tumors: An investigation of the mechanisms involved and their relevance to humans

1990 • 116 citations

Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation

1996 • 92 citations

Identification of S‐1,2,2‐trichlorovinyl‐N‐acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity

1986 • 91 citations

Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load

1979 • 91 citations

Trichloroethylene exposure and trichloroethylene metabolites in urine and blood

1972 • 88 citations

Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation.

1987 • 82 citations

Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate .beta.-lyase

1988 • 81 citations

Pharmacokinetics of trichloroethylene in volunteers, influence of workload and exposure concentration

1976 • 80 citations

Metabolism of trichloroethylene in man

1972 • 79 citations

The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat

1988 • 68 citations

Thioketene formation from .alpha.-haloalkenyl 2-nitrophenyl disulfides: models for biological reactive intermediates of cytotoxic S-conjugates

1991 • 66 citations

Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene

1979 • 61 citations

Biological half-life of trichloroethylene and tetrachloroethylene in human subjects

1973 • 56 citations

Limited capacity of humans to metabolize tetrachloroethylene

1983 • 48 citations

Metabolism of Tetrachloroethene in Rats: Identification of N.epsilon.-(Dichloroacetyl)-L-lysine and N.epsilon.-(Trichloroacetyl)-L-lysine as Protein Adducts

1994 • 34 citations

N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure.

1996 • 30 citations

Biosynthesis, bioactivation, and mutagenicity of S-conjugates

1990 • 23 citations

Metabolism of 1,1-dichloro-2,2,2-trifluoroethane in rats

1994 • 21 citations

Quantitation of the tetrachloroethylene metaboliteN-acetyl-S-(trichlorovinyl)cysteine in rat urinevia negative ion chemical ionization gas chromatography/tandem mass spectrometry

1994 • 17 citations

The Role of Cytochrome P450 2E1 in the Species-Dependent Biotransformation of 1,2-Dichloro-1,1,2-Trifluoroethane in Rats and Mice

1995 • 12 citations