Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

Ionic channels of excitable membranes

1985 • 1,185 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Receptor sites for Ca2+ channel antagonists

1992 • 382 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Molecular determinants of voltage-dependent inactivation in calcium channels

1994 • 217 citations

Inactivation of sodium channels: second order kinetics in myelinated nerve

1977 • 201 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Transfer of 1,4-Dihydropyridine Sensitivity from L-Type to Class A (BI) Calcium Channels

1996 • 151 citations

Molecular Determinants of High Affinity Phenylalkylamine Block of L-type Calcium Channels

1995 • 136 citations

Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium.

1991 • 110 citations

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

1985 • 108 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1992 • 100 citations

Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock.

1984 • 95 citations

Transfer of High Sensitivity for Benzothiazepines from L-type to Class A (BI) Calcium Channels

1996 • 91 citations

Membrane capacity measurements on frog skeletal muscle in media of low ion content. With an Appendix

1974 • 85 citations

Calcium channels from Cyprinus carpio skeletal muscle.

1991 • 70 citations

Transfer of L-type Calcium Channel IVS6 Segment Increases Phenylalkylamine Sensitivity of α1A

1996 • 51 citations

Extracellular localization of the benzothiazepine binding domain of L-type Ca2+ channels.

1993 • 48 citations

Ultra-slow voltage-dependent inactivation of the calcium current in guinea-pig and ferret ventricular myocytes

1994 • 47 citations

The block of the expressed L‐type calcium channel is modulated by the β₃ subunit

1995 • 34 citations

Mechanism of calcium channel block by D600 in single smooth muscle cells from rabbit ear artery.

1989 • 29 citations

The benzazepine/benzothiazepine binding domain of the cardiac L-type Ca2+ channel is accessible only from the extracellular side

1993 • 22 citations

Extra‐ and intracellular action of quaternary devapamil on muscle L‐type Ca²⁺‐channels

1996 • 17 citations

Participation of intracellular sites in the action of Ca2+ channel blockers

1986 • 17 citations

Effect of procaine and calcium ions on slow sodium inactivation in the frog ranvier node membrane

1974 • 14 citations

Myocytes isolated from porcine coronary arteries: reduction of currents through L-type Ca-channels by verapamil-type Ca-antagonists.

1991 • 13 citations

Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site

1997 • 11 citations

D-600 blocks open Ca2+ channels more profoundly than closed ones

1987 • 10 citations