Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA

1988 • 803 citations

A novel type of cardiac calcium channel in ventricular cells

1985 • 745 citations

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

1985 • 715 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.

1986 • 594 citations

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

1984 • 553 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates

1985 • 398 citations

Calcium channels: Molecular pharmacology, structure and regulation

1988 • 382 citations

Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

1989 • 297 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers.

1986 • 217 citations

Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644.

1986 • 199 citations

Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.

1986 • 190 citations

High selectivity of calcium channels in single dialysed heart cells of the guinea‐pig.

1984 • 186 citations

Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.

1987 • 161 citations

An intrinsic potential‐dependent inactivation mechanism associated with calcium channels in guinea‐pig myocytes.

1987 • 134 citations

Calcium Channel Blocking Properties of Amlodipine in Vascular Smooth Muscle and Cardiac Muscle In Vitro: Evidence for Voltage Modulation of Vascular Dihydropyridine Receptors

1987 • 129 citations

Dual effects of dihydropyridines on whole cell and unitary calcium currents in single ventricular cells of guinea‐pig.

1986 • 126 citations

The 165‐KDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel

1987 • 117 citations

Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers.

1982 • 115 citations

Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.

1989 • 106 citations

Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor.

1989 • 94 citations

Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells

1988 • 84 citations

Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

1985 • 84 citations

A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes.

1987 • 78 citations

Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines.

1987 • 77 citations

Profile of the oppositely acting enantiomers of the dihydropyridine 202–791 in cardiac preparations: Receptor binding, electrophysiological, and pharmacological studies

1985 • 71 citations

Pharmacologic and radioligand binding analysis of the actions of 1,4-dihydropyridine activator-antagonist pairs in smooth muscle.

1986 • 71 citations

Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: implications for channel gating.

1987 • 71 citations

?-conotoxin blockade distinguishes Ca from Na permeable states in neuronal calcium channels

1988 • 46 citations

Drugs Acting on Calcium Channels

1988 • 46 citations

D 600 block of L-type Ca2+ channel in vascular smooth muscle cells: comparison with permanently charged derivative, D 890

1989 • 37 citations

Calcium Channels: Mechanisms Of Selectivity, Permeation, And Block

1987 • 28 citations

Increase in the slow inward current by intracellularly applied nifedipine and nicardipine in single ventricular cells of the guinea-pig heart

1984 • 28 citations

Internal and external effects of dihydropyridines in the calcium channel of skeletal muscle.

1990 • 23 citations

Calcium Channels: Introduction into Their Molecular Pharmacology

1985 • 23 citations

Modulation of Ca Channels in Peripheral Neurons^a

1989 • 8 citations

Sodium Currents Through Neuronal Calcium Channels: Kinetics and Sensitivity to Calcium Antagonists

1988 • 4 citations