Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of theCYP2H1Gene

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Eukaryotic Transcription: An Interlaced Network of Transcription Factors and Chromatin-Modifying Machines

1998 • 561 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Molecular genetics of the P-450 superfamily

1990 • 496 citations

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

1998 • 466 citations

Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

2002 • 455 citations

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

2000 • 447 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

1998 • 230 citations

Nuclear Receptors in Sicily: All in the Famiglia

1997 • 152 citations

A novel function of the transforming domain of E1a: Repression of AP-1 activity

1990 • 142 citations

Chromatin: Histone acetyltransferases in control

1997 • 139 citations

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

2000 • 126 citations

E1A directly binds and regulates the P/CAF acetyltransferase

1998 • 124 citations

p300 and CBP as transcriptional regulators and targets of oncogenic events.

1996 • 110 citations

The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.

1999 • 104 citations

The CYP2B2 Phenobarbital Response Unit Contains an Accessory Factor Element and a Putative Glucocorticoid Response Element Essential for Conferring Maximal Phenobarbital Responsiveness

1998 • 88 citations

TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS

1998 • 80 citations

Sequence of a Chicken Phenobarbital-Inducible Cytochrome P450 cDNA: Regulation of Two P450 mRNAs Transcribed from Different Genes

1989 • 49 citations

The Adenovirus E1A-associated 300-kD Protein Exhibits Properties of a Transcriptional Coactivator and Belongs to an Evolutionarily Conserved Family

1994 • 46 citations

Chromatin Assembly Enhances Binding to the CYP2B1Phenobarbital-responsive Unit (PBRU) of Nuclear Factor-1, Which Binds Simultaneously with Constitutive Androstane Receptor (CAR)/Retinoid X Receptor (RXR) and Enhances CAR/RXR-mediated Activation of the PBRU

2001 • 46 citations

A Conserved Nuclear Receptor Consensus Sequence (DR-4) Mediates Transcriptional Activation of the Chicken CYP2H1 Gene by Phenobarbital in a Hepatoma Cell Line

2000 • 42 citations

Isolation and characterization of genomic clones for two chicken phenobarbital-inducible cytochrome P-450 genes.

1986 • 24 citations

Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor.

2001 • 23 citations

Phenobarbital-Induced Activation ofCYP2H1and 5-Aminolevulinate Synthase Genes in Chick Embryo Hepatocytes Is Blocked by an Inhibitor of Protein Phosphorylation

1996 • 18 citations

Liver-Enriched Transcription Factors, HNF-1, HNF-3, and C/EBP, Are Major Contributors to the Strong Activity of the ChickenCYP2H1Promoter in Chick Embryo Hepatocytes

1997 • 17 citations

Analysis of a Phenobarbital-Responsive Enhancer Sequence Located in the 5′ Flanking Region of the ChickenCYP2H1Gene: Identification and Characterization of Functional Protein-Binding Sites

1999 • 15 citations