Hirudin in Acute Myocardial Infarction

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction

1993 • 3,911 citations

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS

1994 • 3,408 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients

1994 • 2,993 citations

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin

1995 • 2,330 citations

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular Function, and Survival after Acute Myocardial Infarction

1993 • 1,861 citations

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

1990 • 1,132 citations

Predictors of 30-Day Mortality in the Era of Reperfusion for Acute Myocardial Infarction

1995 • 1,093 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

Heparin

1991 • 809 citations

Platelet Glycoprotein IIb/IIIa Receptors in Cardiovascular Medicine

1995 • 769 citations

Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

1987 • 751 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

In-hospital mortality and clinical course of 20 891 patients with suspected acute myocardial infarction randomised between alteplase and streptokinase with or without heparin

1990 • 612 citations

Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety

1992 • 548 citations

Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators.

1994 • 505 citations

Treatment of myocardial infarction in the United States (1990 to 1993). Observations from the National Registry of Myocardial Infarction.

1994 • 488 citations

Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial.

1994 • 463 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. TAMI Study Group.

1990 • 423 citations

Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety

1995 • 366 citations

Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor.

1989 • 335 citations

Initiation and regulation of tissue factor-dependent blood coagulation.

1992 • 287 citations

Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK)

1994 • 285 citations

A randomized controlled trial of intravenous tissue plasminogen activator and early intravenous heparin in acute myocardial infarction.

1989 • 276 citations

Antithrombotic agents in coronary artery disease

1989 • 264 citations

A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial

1994 • 259 citations

The development of hirudin as an antithrombotic drug

1994 • 246 citations

Hirudin, heparin, and placebo during deep arterial injury in the pig. The in vivo role of thrombin in platelet-mediated thrombosis.

1990 • 227 citations

EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCER

1989 • 224 citations

RANDOMISED CONTROLLED TRIAL OF SUBCUTANEOUS CALCIUM-HEPARIN IN ACUTE MYOCARDIAL INFARCTION

1989 • 221 citations

When Was a 'Negative' Clinical Trial Big Enough?

1985 • 214 citations

Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: A meta-analysis

1992 • 187 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 4 trial

1994 • 181 citations

Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo.

1989 • 171 citations

The complete amino acid sequence of hirudin, a thrombin specific inhibitor

1984 • 170 citations

Activation/inactivation of human factor V by plasmin

1989 • 159 citations

Relative efficacy of antithrombin compared with antiplatelet agents in accelerating coronary thrombolysis and preventing early reocclusion.

1991 • 152 citations

Risk stratification before thrombolytic therapy in patients with acute myocardial infarction

1990 • 140 citations

Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis.

1992 • 134 citations

Lysis of plasminogen activator-resistant platelet-rich coronary artery thrombus with combined bolus injection of recombinant tissue-type plasminogen activator and antiplatelet GPIIb/IIIa antibody

1990 • 121 citations

Activation of prothrombin accompanying thrombolysis with recombinant tissue-type plasminogen activator

1992 • 111 citations

Novel antiplatelet therapies for treatment of patients with ischemic heart disease: Inhibitors of the platelet glycoprotein IIbIIIa integrin receptor

1995 • 109 citations

Initial experience withhirudin andstreptokinase in acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 6 trial

1995 • 98 citations

Combination of platelet fibrinogen receptor antagonist and direct thrombin inhibitor at low doses markedly improves thrombolysis.

1994 • 91 citations

Maintenance of Coronary Patency After Fibrinolysis With Tissue Factor Pathway Inhibitor

1995 • 50 citations

Are both aspirin and heparin justified as adjuncts to thrombolytic therapy for acute myocardial infarction?

1993 • 48 citations

Prognosis of patients ≽70 years of age with non-Q-wave acute myocardial infarction compared with younger patients with similar infarcts and with patients ≥70 years of age with Q-wave acute myocardial infarction

1995 • 48 citations

REDUCTION IN MAJOR MORBIDITY AND MORTALITY BY HEPARIN IN ACUTE MYOCARDIAL-INFARCTION

1989 • 42 citations

Failure of fixed dose intravenous heparin to suppress increases in thrombin activity after coronary thrombolysis with streptokinase

1994 • 41 citations

Hirudin: Initial results in acute myocardial infarction, unstable angina and angioplasty

1995 • 40 citations

Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis.

1993 • 39 citations

Does Antithrombotic Therapy Influence Residual Thrombus After Thrombolysis of Platelet-Rich Thrombus?

1996 • 38 citations

New Antithrombotics

1995 • 33 citations

Activation of blood coagulation by plaque rupture: Mechanisms and prevention

1995 • 31 citations

Issues regarding the use of heparin following streptokinase therapy

1995 • 24 citations

Role of new anticoagulants as adjunctive therapy during thrombolysis

1991 • 13 citations

755-2 Current Management of ST Elevation Myocardial Infarction and Outcome of Thrombolytic Ineligible Patients: Results of the Multicenter TIMI 9 Registry

1995 • 13 citations

Effects of Heparin and Hirudin (CGP 39393) on Thrombin Generation During Thrombolysis for Acute Myocardial Infarction

1995 • 11 citations

Deleted Work

1955 • 0 citations