Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Calibration of the angular dependence of the amide proton-Cα proton coupling constants, 3JHNα, in a globular protein

1984 • 956 citations

Determination of three‐dimensional structures of proteins from interproton distance data by hybrid distance geometry‐dynamical simulated annealing calculations

1988 • 775 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

PRINCIPLES THAT DETERMINE THE STRUCTURE OF PROTEINS

1984 • 645 citations

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 • 641 citations

Solution conformation of proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance and distance geometry

1985 • 610 citations

Protein structures in solution by nuclear magnetic resonance and distance geometry

1987 • 569 citations

β-Sheet topology and the relatedness of proteins

1977 • 541 citations

Buildup rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: implications for studies of protein conformation

1981 • 504 citations

A protein structure from nuclear magnetic resonance data

1985 • 464 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase.

1975 • 330 citations

Three-dimensional structure of proteins determined by molecular dynamics with interproton distance restraints: application to crambin.

1986 • 322 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

Systematic application of high‐resolution, phase‐sensitive two‐dimensional ¹H‐NMR techniques for the identification of the amino‐acid‐proton spin systems in proteins

1985 • 292 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase

1975 • 267 citations

Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.

1990 • 247 citations

Molecular structure of the bilin binding protein (BBP) from Pieris brassicae after refinement at 2.0 Å resolution

1987 • 228 citations

The three-dimensional structure of P2 myelin protein.

1988 • 221 citations

Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate

1990 • 199 citations

Similarities of protein topologies: evolutionary divergence, functional convergence or principles of folding?

1980 • 194 citations

Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion

1990 • 164 citations

Rapamycin and FK506 binding proteins (immunophilins)

1991 • 136 citations

Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics

1990 • 123 citations

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

1991 • 123 citations

Molecular dynamics simulations with experimental restraints

1991 • 120 citations

Stereospecific assignments of ¹H‐nmr methyl lines and conformation of valyl residues in the lac repressor headpiece

1985 • 120 citations

Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein

1991 • 50 citations

FK506 and rapamycin binding to FKBP: common elements in immunophilin-ligand complexation

1991 • 41 citations

Deduction and systematic classification of spatial motifs of the antiparallel β structure in globular proteins

1987 • 23 citations

FKBP, thought to be identical to PKCI-2, does not inhibit protein kinase C

1991 • 6 citations