Extracellular ATP Triggers Tumor Necrosis Factor‐α Release from Rat Microglia

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

1998 • 709 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages.

1997 • 606 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1991 • 489 citations

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

1997 • 477 citations

The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death

1995 • 378 citations

Inhibition of TNF-induced apoptosis by NF-κB

1998 • 370 citations

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

1993 • 350 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 319 citations

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

1993 • 318 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 305 citations

Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)

1997 • 284 citations

ATP-mediated cytotoxicity in microglial cells

1997 • 280 citations

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death

1999 • 276 citations

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

1991 • 273 citations

Ischemic and Excitotoxic Brain Injury is Enhanced in Mice Lacking the p55 Tumor Necrosis Factor Receptor

1998 • 254 citations

ATP induces nucleotide permeability in rat mast cells

1979 • 252 citations

Mitogen-activated protein kinases activated by lipopolysaccharide and β-amyloid in cultured rat microglia

1998 • 213 citations

Mitogenic Signaling by ATP/P2Y Purinergic Receptors in Astrocytes: Involvement of a Calcium-Independent Protein Kinase C, Extracellular Signal-Regulated Protein Kinase Pathway Distinct from the Phosphatidylinositol-Specific Phospholipase C/Calcium Pathway

1999 • 203 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain

1993 • 173 citations

P2X7/P2Z Purinoreceptor-mediated Activation of Transcription Factor NFAT in Microglial Cells

1999 • 153 citations

Activation of p38^MAPK in Microglia After Ischemia

1998 • 152 citations

Identification of Elastase as a Secretory Protease from Cultured Rat Microglia

1992 • 137 citations

ATP stimulation of Ca²⁺‐dependent plasminogen release from cultured microglia

1998 • 116 citations

Characterization and possible function of adenosine 5′‐triphosphate receptors in activated rat microglia

1994 • 99 citations

Inhibition of p75 Tumor Necrosis Factor Receptor by Antisense Oligonucleotides Increases Hypoxic Injury and β-Amyloid Toxicity in Human Neuronal Cell Line

1997 • 99 citations

Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription, and degranulation.

1997 • 98 citations

<b>Inhibitory effect of peripheral myelin P2 protein on the proliferation of a tumor cell </b><b>line </b>

1989 • 86 citations

Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process.

1994 • 85 citations

V delta 1+ subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes.

1992 • 83 citations

Role of the Purinergic P2Z Receptor in Spontaneous Cell Death in J774 Macrophage Cultures

1996 • 72 citations

Purinoceptor‐operated cationic channels in human B lymphocytes.

1997 • 69 citations

Coexistence of purino‐ and pyrimidinoceptors on activated rat microglial cells

1997 • 63 citations

Characterization and transduction mechanisms of purinoceptors in activated rat microglia

1994 • 59 citations

Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.

1992 • 56 citations

THE FUNCTIONS OF ATP RECEPTORS IN THE HIPPOCAMPUS

1998 • 33 citations

Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons

1994 • 29 citations

Purinoceptor-operated cationic channels in human B lymphocytes. J Physiol 498(Pt 1):143-151

1997 • 9 citations