Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

Roles for Insulin Receptor, PI3-Kinase, and Akt in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

2000 • 736 citations

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

1996 • 735 citations

Hemodynamic actions of insulin

1994 • 606 citations

Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179

2001 • 536 citations

Insulin Resistance, Hyperlipidemia, and Hypertension in Mice Lacking Endothelial Nitric Oxide Synthase

2001 • 520 citations

Direct In Vivo Visualization of Intravascular Destruction of Microbubbles by Ultrasound and its Local Effects on Tissue

1998 • 467 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

Neuronal Nitric-oxide Synthase-μ, an Alternatively Spliced Isoform Expressed in Differentiated Skeletal Muscle

1996 • 355 citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

2003 • 329 citations

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

2003 • 302 citations

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

2000 • 294 citations

Interactions Between Microbubbles and Ultrasound: In Vitro and In Vivo Observations

1997 • 284 citations

Insulin-induced vasodilatation: physiology or pharmacology?

1998 • 271 citations

Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration

2002 • 270 citations

Physiologic Hyperinsulinemia Enhances Human Skeletal Muscle Perfusion by Capillary Recruitment

2001 • 256 citations

Hemodynamic Actions of Insulin in Rat Skeletal Muscle: Evidence for Capillary Recruitment

1997 • 238 citations

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

2000 • 209 citations

Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow

2002 • 208 citations

Effect of Insulin on Acetylcholine-Induced Vasodilation in Normotensive Subjects and Patients With Essential Hypertension

1995 • 193 citations

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

2000 • 177 citations

Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo

2002 • 164 citations

Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats

2002 • 162 citations

Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound

2002 • 147 citations

The Insulin Receptor - A Critical Link in Glucose Homeostasis and Insulin Action

1998 • 140 citations

Role of Tissue-Specific Blood Flow and Tissue Recruitment in Insulin-Mediated Glucose Uptake of Human Skeletal Muscle

1998 • 139 citations

Active and passive capillary control in red muscle at rest and in exercise

1982 • 124 citations

Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters

1999 • 121 citations

Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

1999 • 117 citations

Effect of perfusion rate on the time course of insulin-mediated skeletal muscle glucose uptake

1996 • 93 citations

Kinetics of Insulin Action In Vivo: Identification of Rate-Limiting Steps

1995 • 87 citations

B. W. Zweifach award lecture

1985 • 81 citations

Changes in myocardial blood volume with graded coronary stenosis

1997 • 64 citations

Detection of Individual Microbubbles of an Ultrasound Contrast Agent

2002 • 57 citations

Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

2001 • 55 citations

Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment

1997 • 51 citations

Kinetics of insulin action in vivo. Identification of rate-limiting steps

1995 • 31 citations

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