Insulin-induced vasodilatation: physiology or pharmacology?

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Data on the distribution of fibre types in thirty-six human muscles

1973 • 2,111 citations

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.

1996 • 1,695 citations

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

1994 • 1,200 citations

Positron-emission tomography

1997 • 1,179 citations

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

1985 • 1,147 citations

Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

1991 • 1,073 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

1979 • 779 citations

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

1980 • 754 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

1979 • 746 citations

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

1996 • 735 citations

Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings.

1989 • 630 citations

Insulin resistance is a characteristic feature of primary hypertension independent of obesity

1990 • 535 citations

FOREARM METABOLISM IN OBESITY AND ITS RESPONSE TO INTRA-ARTERIAL INSULIN. CHARACTERIZATION OF INSULIN RESISTANCE AND EVIDENCE FOR ADAPTIVE HYPERINSULINISM*

1962 • 499 citations

Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia

1992 • 475 citations

Hormonal regulation of the Na(+)-K(+)-ATPase: mechanisms underlying rapid and sustained changes in pump activity

1995 • 473 citations

Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM

1992 • 451 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia

1996 • 411 citations

Nitric oxide release is present from incubated skeletal muscle preparations

1994 • 410 citations

THE QUANTITATIVELY MINOR ROLE OF CARBOHYDRATE IN OXIDATIVE METABOLISM BY SKELETAL MUSCLE IN INTACT MAN IN THE BASAL STATE. MEASUREMENTS OF OXYGEN AND GLUCOSE UPTAKE AND CARBON DIOXIDE AND LACTATE PRODUCTION IN THE FOREARM 12

1956 • 393 citations

THEORY OF THE USE OF ARTERIOVENOUS CONCENTRATION DIFFERENCES FOR MEASURING METABOLISM IN STEADY AND NON-STEADY STATES*

1961 • 383 citations

Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure.

1993 • 374 citations

Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans.

1995 • 372 citations

The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients.

1993 • 369 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans.

1993 • 324 citations

The sympathetic response to euglycaemic hyperinsulinaemia

1992 • 296 citations

Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.

1994 • 287 citations

Chronic Hyperglycemia Impairs Endothelial Function and Insulin Sensitivity Via Different Mechanisms in Insulin-Dependent Diabetes Mellitus

1996 • 284 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Insulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical Training

1995 • 257 citations

Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension.

1992 • 247 citations

Hemodynamic Actions of Insulin in Rat Skeletal Muscle: Evidence for Capillary Recruitment

1997 • 238 citations

Variability of fiber type distributions within human muscles

1982 • 220 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

Mechanism of Insulin Resistance in Insulin-Dependent Diabetes Mellitus: A Major Role for Reduced Skeletal Muscle Blood Flow*

1991 • 213 citations

Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.

1990 • 204 citations

Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake

1994 • 200 citations

Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans

1996 • 199 citations

Effect of Insulin on Acetylcholine-Induced Vasodilation in Normotensive Subjects and Patients With Essential Hypertension

1995 • 193 citations

Roles of Glucose Transport and Glucose Phosphorylation in Muscle Insulin Resistance of NIDDM

1996 • 180 citations

Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

1994 • 173 citations

Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.

1996 • 155 citations

Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects

1995 • 155 citations

Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men.

1994 • 154 citations

EFFECT OF INSULIN ON CARBOHYDRATE METABOLISM AND ON POTASSIUM IN THE FOREARM OF MAN*

1962 • 153 citations

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.

1993 • 152 citations

Impaired insulin action on skeletal muscle metabolism in essential hypertension.

1991 • 147 citations

Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM

1992 • 143 citations

Vascular and endocrine control of muscle metabolism

1995 • 142 citations

Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans.

1993 • 137 citations

Acute noradrenergic activation induces insulin resistance in human skeletal muscle

1994 • 135 citations

Localization of Rate-Limiting Defect for Glucose Disposal in Skeletal Muscle of Insulin-Resistant Type I Diabetic Patients

1990 • 129 citations

Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy.

1991 • 124 citations

FOREARM METABOLISM IN OBESITY AND ITS RESPONSE TO INTRA-ARTERIAL INSULIN EVIDENCE FOR ADAPTIVE HYPERINSULINISM

1961 • 119 citations

Insulin reduces contraction and intracellular calcium concentration in vascular smooth muscle.

1993 • 115 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues IV. The ‘insulin-like’ effect of Li+

1968 • 115 citations

Insulin resistance is associated with high sodium-lithium countertransport in essential hypertension

1991 • 115 citations

Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism.

1993 • 113 citations

Mechanisms of Hyperglycemia-Induced Insulin Resistance in Whole Body and Skeletal Muscle of Type I Diabetic Patients

1992 • 106 citations

Capillary rarefaction characteristic of the skeletal muscle of hypertensive patients

1988 • 104 citations

Effects of Insulin on Vascular Tone and Sympathetic Nervous System in NIDDM

1996 • 101 citations

Glucose Transport in Human Skeletal Muscle: The In Vivo Response to Insulin

1993 • 96 citations

Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated

1996 • 94 citations

Insulin resistance and vasodilation in essential hypertension. Studies with adenosine.

1994 • 91 citations

Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels

1995 • 90 citations

Insulin resistance, glucose intolerance, and hyperinsulinemia. Hypertriglyceridemia versus hypercholesterolemia.

1993 • 88 citations

Skeletal muscle is a primary site of insulin resistance in essential hypertension

1991 • 86 citations

Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM

1996 • 79 citations

Activation of the Sodium-Potassium Pump Contributes to Insulin-Induced Vasodilation in Humans

1996 • 78 citations

In vivo insulin action and muscle glycogen synthase activity in Type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment

1992 • 77 citations

Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.

1997 • 75 citations

Insulin-Induced Sympathetic Activation and Vasodilation in Skeletal Muscle: Effects of Insulin Resistance in Lean Subjects

1995 • 73 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues II. Effects of K+-free medium, ouabain and insulin upon the fate of glucose in rat diaphragm

1966 • 73 citations

Normal Effect of Insulin to Stimulate Leg Blood Flow in NIDDM

1995 • 73 citations

Effects of insulin and epinephrine on Na+-K+ and glucose transport in soleus muscle

1987 • 69 citations

Skeletal muscle blood flow

1993 • 68 citations

Insulin Sensitivity, Vascular Reactivity, and Clamp-Induced Vasodilatation in Essential Hypertension

1997 • 68 citations

Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle.

1994 • 67 citations

Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training

1995 • 63 citations

Insulin-stimulated glucose utilization and borderline hypertension in young adult blacks.

1993 • 62 citations

Influence of Bradykinin on Glucose Uptake and Metabolism Studied in Isolated Cardiac Myocytes and Isolated Perfused Rat Hearts

1983 • 61 citations

Role of Nitric Oxide, Adenosine, and ATP-Sensitive Potassium Channels in Insulin-Induced Vasodilation

1996 • 61 citations

Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy-<scp>D</scp>-glucose, and Positron Emission Tomography

1996 • 61 citations

Effects of adrenergic and cholinergic blockade on insulin-induced stimulation of calf blood flow in humans

1994 • 59 citations

Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment

1997 • 51 citations

Insulin resistance in familial and nonfamilial hypercholesterolemia.

1993 • 51 citations

Glucose Metabolism in Abdominally Obese Hypertensive and Normotensive Subjects

1995 • 48 citations

Physical fitness, muscle morphology, and insulin-stimulated limb blood flow in normal subjects

1996 • 48 citations

Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM

1996 • 45 citations

Insulin resistance in type I diabetes mellitus: a major role for reduced glucose extraction.

1996 • 44 citations

Effects of insulin on vascular tone and sympathetic nervous system in NIDDM

1996 • 42 citations

Angiotensin Mediates Forearm Glucose Uptake by Hemodynamic Rather Than Direct Effects

1996 • 42 citations

Relationship between limb and muscle blood flow in man.

1996 • 42 citations

Mechanisms of Arterial Hypotension After Therapeutic Dose of Subcutaneous Insulin in Diabetic Autonomic Neuropathy

1993 • 38 citations

Impaired insulin sensitivity and maximal responsiveness in older hypertensive men.

1994 • 38 citations

Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions

1993 • 36 citations

Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data

1997 • 31 citations

Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects.

1996 • 30 citations

Insulin resistance in type I diabetes mellitus: a major role for reduced glucose extraction

1996 • 27 citations

Insulin sensitivity in familial hypercholesterolemia

1993 • 26 citations

Microvascular blood flow distribution in skeletal muscle. An intravital microscopic study in the rabbit.

1983 • 26 citations

Effects of insulin on whole body and forearm leucine and KIC metabolism in type 1 diabetes

1990 • 25 citations

Insulin and Forearm Vasodilation in Hypertension-Prone Men

1995 • 23 citations

Low-Dose Angiotensin II Increases Glucose Disposal Rate During Euglycemic Hyperinsulinemia

1993 • 23 citations

Insulin-induced sympathetic activation and vasodilatation in skeletal muscle.

1996 • 23 citations

Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects

1995 • 22 citations

Normal effect of insulin to stimulate leg blood flow in NIDDM

1995 • 18 citations

Skeletal muscle blood flow is not a determinant of insulin resistance in essential hypertension

1997 • 15 citations

Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects

1996 • 13 citations

Endothelial Dysfunction, Insulin Resistance and Non-insulin-dependent Diabetes

1997 • 9 citations

Deleted Work

1955 • 0 citations