The development of psychosis in epilepsy: a re-examination of the kindling hypothesis

A synaptic model of memory: long-term potentiation in the hippocampus

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A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

The Schizophrenia-like Psychoses of Epilepsy

1963 • 952 citations

Development of Epileptic Seizures through Brain Stimulation at Low Intensity

1967 • 854 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

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Animal models of the epilepsies

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Dopamine D4 receptors elevated in schizophrenia

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Kindling

1978 • 482 citations

Adenosine: A potential mediator of seizure arrest and postictal refractoriness

1992 • 462 citations

Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology

1993 • 438 citations

NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling

1987 • 401 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Secondary Epileptogenesis in Man

1985 • 331 citations

Kindling: basic mechanisms and clinical validity

1990 • 311 citations

Schizophrenia and the brain: a prospective clinico-neuropathological study

1990 • 287 citations

Interictal Metabolic Anatomy of Mesial Temporal Lobe Epilepsy

1993 • 253 citations

Anatomical correlates of electrical and behavioral events related to amygdaloid kindling

1978 • 247 citations

Is Adenosine an Endogenous Anticonvulsant?

1985 • 243 citations

Epileptogenesis in chronically injured cortex: in vitro studies

1993 • 233 citations

Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging

1993 • 220 citations

Does the Engram of Kindling Model the Engram of Normal Long Term Memory?

1975 • 220 citations

Kindling of the mesolimbic dopamine system

1978 • 210 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_<scp>A</scp> receptors

1994 • 200 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

TheN-methyl-D-aspartate antagonists aminophosphonovalerate and car☐ypiperazinephosphonate retard the development and expression of kindled seizures

1990 • 196 citations

Amygdaloid sclerosis in temporal lobe epilepsy

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In vivo cerebral metabolism and central benzodiazepine‐receptor binding in temporal lobe epilepsy

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Epilepsy in Iceland. A clinical and epidemiological investigation.

1966 • 182 citations

Kindling mechanisms: Current progress on an experimental epilepsy model

1986 • 179 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_A receptors

1994 • 175 citations

Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats

1993 • 170 citations

Quantification of mu and non–mu opiate receptors in temporal lobe epilepsy using positron emission tomography

1991 • 169 citations

Psychiatric Implications of Psychomotor Epilepsy

1966 • 164 citations

Neuropharmacology of Phencyclidine: Basic Mechanisms and Therapeutic Potential

1990 • 160 citations

Electrophysiological properties and synaptic responses in the deep layers of the human epileptogenic neocortex in vitro

1989 • 160 citations

Temporal lobe hypometabolism on PET

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A “Mock up” of schizophrenia: Temporal lobe epilepsy and schizophrenia-like psychosis

1990 • 146 citations

Schizophrenia in epilepsy

1993 • 145 citations

Neurons in human epileptic cortex: Correlation between unit and EEG activity

1982 • 144 citations

Hippocampal sclerosis without detectable hippocampal atrophy

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Schizophrenia: the cellular biology of a functional psychosis

1990 • 137 citations

Kindling, Unit Discharge Patterns and Neural Plasticity

1975 • 134 citations

Human epileptic neurons studied in vitro

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Psychopathology and brain dysfunction

1977 • 128 citations

Epilepsy, psychosis, and schizophrenia

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“Central” and “peripheral” benzodiazepine receptors

1992 • 118 citations

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

1994 • 114 citations

Studies of human and monkey “Epileptic” neocortex in the in vitro slice preparation

1983 • 113 citations

Acute behavioral symptomatology at disappearance of epileptiform EEG abnormality. Paradoxical or "forced" normalization.

1991 • 105 citations

Calcium currents in acutely isolated human neocortical neurons

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Pursuit of the mechanisms of kindling

1988 • 93 citations

Psychiatric Manifestations in Temporal Lobe Epilepsy: A Controlled Study

1979 • 88 citations

Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio

1975 • 86 citations

Anticonvulsant withdrawal‐emergent psychopathology

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Schizophrenia: a disease of interhemispheric processes at forebrain and brainstem levels?

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Asymmetric Interictal Glucose Hypometabolism and Cognitive Performance in Epileptic Patients

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Behavioral and Epileptic Determinants of Predatory Attack Behavior in the Cat

1975 • 80 citations

Neurobiological evidence for epilepsy-induced interictal disturbances.

1991 • 77 citations

Temporal and Spatial Patterns of Expression of c-fos, zif/268, c-jun and jun-B mRNAs in Rat Brain Following Seizures Evoked Focally from the Deep Prepiriform Cortex

1993 • 77 citations

Local synaptic circuits and epileptiform activity in slices of neocortex from children with intractable epilepsy

1992 • 73 citations

Long-term Clinical and EEG Changes in Patients With Epilepsy

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The Clinical Relevance of Kindling

1990 • 69 citations

Hyperexcitability associated with localizable lesions in epileptic patients

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The Molecular Basis of Kindling

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Lasting Behavioral and EEG Changes in Cats Induced by Prolonged Stimulation of Amygdala

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Value of Magnetic Resonance Imaging-Based Measurements of Hippocampal Formations in Patients With Partial Epilepsy

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The relationship between epilepsy and schizophrenia: a biochemical hypothesis.

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A study of cerebral blood flow and metabolism in epileptic psychosis using positron emission tomography and oxygen.

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Recurrent Spontaneous Seizure State Induced by Prefrontal Kindling in Senegalese Baboons, Papio Papio

1975 • 58 citations

Thyrotropin‐Releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures

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Long-lasting hypersensitivity to methamphetamine following amygdaloid kindling in cats: the relationship between limbic epilepsy and the psychotic state.

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Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat.

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Comparison of the Effects of Frontal and Temporal Lobe Partial Seizures on Prolactin Levels

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Experimental neurobiology of epilepsies

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EPILEPSY AND SCHIZOPHRENIA RELATIONSHIP AND BIOCHEMISTRY

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Emerging antiepileptic drugs.

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Epilepsy.

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Epilepsy, psychosis and schizophrenia

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Expression of c-fos mRNA Following Seizures Evoked from an Epileptogenic Site in the Deep Prepiriform Cortex: Regional Distribution in Brain as Shown by in Situ Hybridization

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Psychosis and the temporal lobe.

1991 • 41 citations

Decreased hippocampal muscarinic cholinergic receptor binding measured by ¹²³I‐iododexetimide and single‐photon emission computed tomography in epilepsy

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Kindling induced changes in EEG recorded during stimulation from the site of stimulation: Collapse of GABA-mediated inhibition and onset of rhythmic synchronous burst

1986 • 35 citations

Regional changes in cerebral glucose utilization associated with amygdaloid kindling and electroshock in the rat

1981 • 35 citations

CHRONIC PSYCHOSIS FOLLOWING EPILEPSY

1957 • 32 citations

Serum Cortisol and Cerebrospinal Fluid β-Endorphins in Status Epilepticus

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Interictal psychoses of epilepsy

1984 • 29 citations

The Development of Independent Foci in Epileptic Patients

1990 • 25 citations

Hippocampal synaptic pathology in patients with temporal lobe epilepsy

1994 • 21 citations

Neurochemical substrates of ictal behavior.

1991 • 19 citations

Developments in antiepileptic drug therapy

1994 • 19 citations

Etiologic Factors for Unitemporal vs Bitemporal Epileptiform Discharges

1991 • 19 citations

Interictal psychiatric disorders. Neurochemical aspects.

1991 • 16 citations

The clinical relevance of kindling

1990 • 14 citations