The price of immunity

Pattern Recognition Receptors and Inflammation

2010 • 7,761 citations

Origin and physiological roles of inflammation

2008 • 5,579 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Abdominal obesity and metabolic syndrome

2006 • 4,004 citations

Interactions Between the Microbiota and the Immune System

2012 • 3,793 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

2006 • 3,361 citations

Topographical and Temporal Diversity of the Human Skin Microbiome

2009 • 2,632 citations

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

2008 • 2,577 citations

Inflammatory Bowel Disease

2009 • 2,348 citations

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

2012 • 2,205 citations

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

2006 • 2,010 citations

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

2008 • 1,853 citations

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

2011 • 1,849 citations

Inflammatory Bowel Disease

2010 • 1,627 citations

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

2010 • 1,474 citations

Microbiota regulates immune defense against respiratory tract influenza A virus infection

2011 • 1,353 citations

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

2010 • 1,213 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

Peripheral education of the immune system by colonic commensal microbiota

2011 • 961 citations

Compartmentalized Control of Skin Immunity by Resident Commensals

2012 • 952 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

2012 • 910 citations

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

2010 • 843 citations

The Sterile Inflammatory Response

2010 • 797 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Type I interferon: friend or foe?

2010 • 776 citations

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

2010 • 760 citations

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

2010 • 747 citations

Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis

2010 • 693 citations

Why do viruses cause cancer? Highlights of the first century of human tumour virology

2010 • 688 citations

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

2008 • 639 citations

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

2011 • 637 citations

Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis

2011 • 597 citations

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

2009 • 569 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

2009 • 550 citations

Nucleic Acid Recognition by the Innate Immune System

2011 • 541 citations

A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells

2005 • 530 citations

Friendly and dangerous signals: is the tissue in control?

2006 • 525 citations

The Pathogenesis of Sepsis

2011 • 513 citations

DNA released from dying host cells mediates aluminum adjuvant activity

2011 • 494 citations

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

2012 • 479 citations

Antibiotic use and inflammatory bowel diseases in childhood

2010 • 468 citations

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

2009 • 461 citations

Immunological complications of obesity

2012 • 445 citations

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

2008 • 441 citations

Microbial Translocation Across the GI Tract

2012 • 428 citations

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

2008 • 421 citations

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

2005 • 420 citations

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

2012 • 417 citations

Pathogenesis of hepatitis B virus infection

2010 • 410 citations

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

2010 • 406 citations

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

1998 • 397 citations

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

2012 • 385 citations

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

2012 • 362 citations

Successful Transmission of a Retrovirus Depends on the Commensal Microbiota

2011 • 359 citations

Triggering psoriasis: the role of infections and medications

2007 • 358 citations

“Control” laboratory rodents are metabolically morbid: Why it matters

2010 • 340 citations

Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii

2006 • 339 citations

Regulating the adaptive immune response to respiratory virus infection

2012 • 327 citations

Tissue-based class control: the other side of tolerance

2011 • 326 citations

Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function

2009 • 269 citations

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

2008 • 268 citations

Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin

2011 • 267 citations

NK Cell-Derived Interferon-γ Orchestrates Cellular Dynamics and the Differentiation of Monocytes into Dendritic Cells at the Site of Infection

2012 • 260 citations

The Control of Adaptive Immune Responses by the Innate Immune System

2011 • 258 citations

IL‐10 and IL‐10 receptor defects in humans

2011 • 253 citations

Cancer Cachexia: Mechanisms and Clinical Implications

2011 • 252 citations

Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

2009 • 252 citations

Wounding and Its Role in RSV-Mediated Tumor Formation

1985 • 225 citations

Regulation of interleukin-12 production in antigen-presenting cells

2001 • 213 citations

Crohn's disease: NOD2, autophagy and ER stress converge

2011 • 212 citations

Innate and adaptive immune responses to cell death

2011 • 210 citations

Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii

2009 • 209 citations

Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages.

1985 • 207 citations

Psoriasis – as an autoimmune disease caused by molecular mimicry

2009 • 205 citations

Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

2011 • 197 citations

Interleukin-35 Mediates Mucosal Immune Responses That Protect Against T-Cell–Dependent Colitis

2011 • 193 citations

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

2012 • 188 citations

Inflammation Drives Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn’s Disease

2012 • 187 citations

The interleukin‐23 axis in intestinal inflammation

2008 • 169 citations

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

2011 • 166 citations

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

2008 • 165 citations

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

2012 • 158 citations

Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none

2012 • 157 citations

Segmented filamentous bacteria take the stage

2010 • 152 citations

Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells

2009 • 149 citations

Intestinal microbiota: Shaping local and systemic immune responses

2011 • 144 citations

Subversion of the innate immune system by a retrovirus

2003 • 141 citations

Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

2006 • 139 citations

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses

2012 • 136 citations

Hepatitis B and C virus-related carcinogenesis

2009 • 136 citations

Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora

2010 • 132 citations

Immuno-microbiota cross and talk: The new paradigm of metabolic diseases

2012 • 131 citations

Human genetic susceptibility to intracellular pathogens

2011 • 114 citations

Lowering the Threshold of Lung Innate Immune Cell Activation Alters Susceptibility to Secondary Bacterial Superinfection

2011 • 111 citations

Organ-specific regulation of innate immunity

2006 • 106 citations

Interleukin-15-Dependent NKp46+ Innate Lymphoid Cells Control Intestinal Inflammation by Recruiting Inflammatory Monocytes

2012 • 105 citations

Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity

2001 • 93 citations

Chronic Colitis in IL-10^-/-Mice: Insufficient Counter Regulation of a Th1 Response

2000 • 81 citations

Opportunistic Infection-Associated Immune Reconstitution Syndrome in Transplant Recipients

2011 • 81 citations

Maintaining system homeostasis: the third law of Newtonian immunology

2012 • 78 citations

Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger

2011 • 72 citations

Small intestinal injury in the graft versus host reaction: an innocent bystander phenomenon.

1977 • 66 citations

TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-γ production

2007 • 66 citations

Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections

2010 • 62 citations

Small Intestinal Injury in the Graft Versus Host Reaction: An Innocent Bystander Phenomenon

1977 • 56 citations

Diverse roles of hepatitis B virus in liver cancer

2012 • 49 citations

Serological Markers for Inflammatory Bowel Disease in AIDS Patients with Evidence of Microbial Translocation

2010 • 36 citations

A Novel Role for CD4+ T Cells in the Control of Cachexia

2008 • 33 citations

Intestinal commensals: influence on immune system and tolerance to pathogens

2012 • 28 citations

Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of interleukin 12 p35 transcription in murine bone marrow-derived dendritic cells

2005 • 21 citations

Pathologic Lesions of GVH Disease in Hamsters: Antigenic Target Versus �Innocent Bystander�1

2015 • 18 citations

Are Dysregulated Inflammatory Responses to Commensal Bacteria Involved in the Pathogenesis of Hepatobiliary-Pancreatic Autoimmune Disease? An Analysis Using Mice Models of Primary Biliary Cirrhosis and Autoimmune Pancreatitis

2011 • 12 citations

Murine Syngeneic Graft-Versus-Host Disease Is Responsive to Broad-Spectrum Antibiotic Therapy

2011 • 12 citations

Genome-Wide Association Studies and Infectious Disease

2010 • 11 citations

Meanderings into the Regulation of Effector Class by the Immune System: Derivation of the Trauma Model

2012 • 10 citations

Lymphotoxin and the amazing technicolor circus of intestinal homeostasis

2012 • 1 citations