Recent advances on the role of CD40 and dendritic cells in immunity and tolerance

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells

2001 • 717 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells

2002 • 659 citations

Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells

1999 • 633 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells

1998 • 509 citations

Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets

2001 • 496 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells

2001 • 444 citations

The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte–derived dendritic cells

2000 • 440 citations

The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations

2000 • 418 citations

A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-α, and Contact Sensitizers

2001 • 404 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1

1994 • 382 citations

Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

2001 • 363 citations

CD40, an extracellular receptor for binding and uptake of Hsp70–peptide complexes

2002 • 351 citations

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

1996 • 339 citations

CD40 Is a Cellular Receptor Mediating Mycobacterial Heat Shock Protein 70 Stimulation of CC-Chemokines

2001 • 271 citations

Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

2001 • 261 citations

Antigen-Specific Suppression of a Primed Immune Response by Dendritic Cells Mediated by Regulatory T Cells Secreting Interleukin-10

2003 • 253 citations

Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells

2002 • 232 citations

Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering

2002 • 231 citations

Characterization of a common precursor population for dendritic cells

2002 • 223 citations

Toxoplasma gondiiTachyzoites Inhibit Proinflammatory Cytokine Induction in Infected Macrophages by Preventing Nuclear Translocation of the Transcription Factor NF-κB

2001 • 211 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

Infectious tolerance

1998 • 198 citations

CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)

1999 • 184 citations

Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells

2000 • 175 citations

CD40 Ligation Conditions Dendritic Cell Antigen-Presenting Function Through Sustained Activation of NF-κB

2002 • 157 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

4-1BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8 T Cells in a CD40-Dependent Manner

2002 • 138 citations

Regulation of CD40 function by its isoforms generated through alternative splicing

2001 • 136 citations

Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell

2002 • 134 citations

Multifocal defects in immune responses in RelB-deficient mice.

1997 • 131 citations

Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells

1999 • 126 citations

Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells.

2000 • 124 citations

Bacterial Lipopolysaccharide, TNF-α, and Calcium Ionophore Under Serum-Free Conditions Promote Rapid Dendritic Cell-Like Differentiation in CD14+ Monocytes Through Distinct Pathways That Activate NF-κB

2000 • 117 citations

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes

2002 • 117 citations

Role of NFκB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI

2001 • 113 citations

Cutting Edge: Identification of c-Rel-Dependent and -Independent Pathways of IL-12 Production During Infectious and Inflammatory Stimuli

2002 • 105 citations

Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40

1999 • 98 citations

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation

1999 • 98 citations

Phorbol Ester Inhibits the Phosphorylation of the Retinoblastoma Protein without Suppressing Cyclin D-associated Kinase in Vascular Smooth Muscle Cells

1996 • 96 citations

Cutting Edge: CD91-Independent Cross-Presentation of GRP94(gp96)-Associated Peptides

2002 • 92 citations

Differential Expression of the Transcription Factor NF-κB during Human Mononuclear Phagocyte Differentiation to Macrophages and Dendritic Cells

2000 • 80 citations

Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement.

1997 • 72 citations

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

2000 • 69 citations

CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection

1999 • 69 citations

The Role of Sp1 and NF-κB in Regulating CD40 Gene Expression

2002 • 66 citations

Immunobiology of dendritic cells in the rat

2001 • 61 citations

Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL

2002 • 60 citations

TNF-alpha, unlike other pro- and anti-inflammatory cytokines, induces rapid release of the IL-1 type II decoy receptor in human myelomonocytic cells.

1997 • 57 citations

Differential activation of NF-κB subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide

2001 • 56 citations

RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function

2000 • 54 citations

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

2002 • 38 citations

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

2002 • 37 citations

CD4+ T Cell Responses to CD40-Deficient APCs: Defects in Proliferation and Negative Selection Apply Only with B Cells as APCs

1999 • 36 citations

Regulation of major histocompatibility complex class I expression by NF-κB-related proteins in breast cancer cells

1998 • 33 citations

Dendritic-Like Cells from relB Mutant Mice

1997 • 14 citations