A method for estimation of drug affinity constants to the open conformational state of calcium channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.

1978 • 176 citations

Calcium currents of cesium loaded isolated smooth muscle cells (urinary bladder of the guinea pig)

1985 • 130 citations

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

1985 • 108 citations

Nonmodal gating of cardiac calcium channels as revealed by dihydropyridines.

1989 • 99 citations

Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock.

1984 • 95 citations

The rates of interaction of local anesthetics with sodium channels in nerve.

1978 • 89 citations

Calcium Channels

1988 • 81 citations

Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine

1990 • 58 citations

Mechanism of calcium channel block by D600 in single smooth muscle cells from rabbit ear artery.

1989 • 29 citations

Characterization of the calcium channel state transitions induced by the enantiomers of the 1,4-dihydropyridine Sandoz 202 791 in neonatal rat heart cells

1989 • 26 citations

The blockade of $$\dot V_{\max }$$ of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine

1981 • 22 citations

Tiapamil reduces the calcium inward current of isolated smooth muscle cells. Dependence on holding potential and pulse frequency

1986 • 18 citations

D-600 blocks open Ca2+ channels more profoundly than closed ones

1987 • 10 citations