Protein Folding and Protein Association

Principles of Polymer Chemistry.

1954 • 16,197 citations

Principles of polymer chemistry

1995 • 15,622 citations

Statistical mechanics of chain molecules

1969 • 6,455 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Stability of Proteins Small Globular Proteins

1979 • 2,139 citations

Protein Denaturation

1968 • 2,108 citations

Structural chemistry and molecular biology

1968 • 1,698 citations

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

1970 • 1,550 citations

Are there pathways for protein folding?

1968 • 1,496 citations

A thermodynamic approach to the problem of stabilization of globular protein structure: A calorimetric study

1974 • 1,384 citations

Structure and stability of biological macromolecules

1969 • 1,313 citations

Protein Denaturation

1970 • 1,264 citations

THE KINETICS OF FORMATION OF NATIVE RIBONUCLEASE DURING OXIDATION OF THE REDUCED POLYPEPTIDE CHAIN

1961 • 1,148 citations

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

1979 • 1,136 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Principles of protein structure

1980 • 1,094 citations

Principles of Protein Structure

1979 • 1,090 citations

Stability of proteins. Proteins which do not present a single cooperative system.

1982 • 1,041 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

FATTY ACID SYNTHESIS AND ITS REGULATION

1983 • 1,007 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

Theoretical Studies of Protein Folding

1983 • 831 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

The structure and action of proteins

1969 • 741 citations

Stability of Proteins

1982 • 718 citations

Solvent viscosity and protein dynamics

1980 • 657 citations

2 Evolutionary and Structural Relationships among Dehydrogenases

1975 • 607 citations

Protein-Protein Interactions

1954 • 574 citations

Assembly and Stability of the Tobacco Mosaic Virus Particle

1964 • 549 citations

Experimental studies of protein folding and unfolding

1979 • 535 citations

Physical methods of chemistry

1971 • 496 citations

Biological Regulation and Development

1982 • 489 citations

24 Bovine Pancreatic Ribonuclease

1971 • 437 citations

Protein disk of tobacco mosaic virus at 2.8 Å resolution showing the interactions within and between subunits

1978 • 406 citations

From Macromolecules to Biological Assemblies (Nobel Lecture)

1983 • 369 citations

A salt bridge stabilizes the helix formed by isolated C-peptide of RNase A.

1982 • 284 citations

Structural domains in proteins and their role in the dynamics of protein function

1983 • 283 citations

Reconstitution of lactic dehydrogenase. Noncovalent aggregation vs. reactivation. 1. Physical properties and kinetics of aggregation

1979 • 282 citations

ENZYMES UNDER EXTREMES OF PHYSICAL CONDITIONS

1981 • 275 citations

Computer analysis of protein-protein interaction

1978 • 270 citations

Intermediates in Protein Folding Reactions and the Mechanism of Protein Folding

1975 • 257 citations

States of Aggregation of Tobacco Mosaic Virus Protein

1971 • 250 citations

Acquisition of Three-Dimensional Structure of Proteins

1973 • 248 citations

Enzymes: Physical principles

1973 • 245 citations

Acid catalysis of the formation of the slow-folding species of RNase A: Evidence that the reaction is proline isomerization

1978 • 229 citations

Hierarchic organization of domains in globular proteins

1979 • 228 citations

Assembly of the Particle of Tobacco Mosaic Virus from RNA and Disks of Protein

1971 • 223 citations

Folding of Protein Fragments

1981 • 215 citations

The Current Picture of the Structure and Assembly of Tobacco Mosaic Virus

1984 • 211 citations

Protein Folding

1981 • 206 citations

Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.

1979 • 199 citations

An explanation for the rare occurrence of cis peptide units in proteins and polypeptides

1976 • 199 citations

The structure of the protein disk of tobacco mosaic virus to 5 Å resolution

1976 • 195 citations

Enzymes: physical principles

1972 • 191 citations

Protein Denaturation and the Properties of Protein Groups

1945 • 190 citations

Diffusion–collision model for protein folding

1979 • 183 citations

Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase

1983 • 179 citations

Analytical approximation to the accessible surface area of proteins

1980 • 175 citations

A quantitative treatment of the kinetics of the folding transition of ribonuclease A

1976 • 167 citations

Multi-functional Proteins

1981 • 164 citations

Role of proline isomerization in folding of ribonuclease A at low temperatures

1979 • 161 citations

Mechanism of folding of ribonuclease A. Slow refolding is a sequential reaction via structural intermediates

1983 • 158 citations

Both the Fast and Slow Refolding Reactions of Ribonuclease A Yield Native Enzyme

1973 • 157 citations

Kinetic aspects of conformational changes in proteins. I. Rate of regain of enzyme activity from denatured proteins

1971 • 156 citations

Effect of proline residues on protein folding

1981 • 155 citations

Detection of an early intermediate in the folding of ribonuclease A by protection of amide protons against exchange

1979 • 154 citations

Entropy-Driven Processes in Biology

1975 • 153 citations

Topics in Molecular Pharmacology

1984 • 141 citations

Test of the extended two-state model for the kinetic intermediates observed in the folding transition of ribonuclease A

1978 • 137 citations

Polymerization of Tobacco Mosaic Virus Protein and its Control

1971 • 137 citations

Long Term Persistence of Parathion in Soil

1971 • 127 citations

Inside-out model for self-assembly of tobacco mosaic virus.

1977 • 126 citations

ANTIBODIES TO A UNIQUE REGION IN LYSOZYME PROVOKED BY A SYNTHETIC ANTIGEN CONJUGATE

1969 • 124 citations

Some Applications of Calorimetry in Biochemistry and Biology

1974 • 124 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 118 citations

Trimeric intermediate in the in vivo folding and subunit assembly of the tail spike endorhamnosidase of bacteriophage P22.

1982 • 114 citations

Temperature-sensitive mutants blocked in the folding or subunit assembly of the bacteriophage P22 tail spike protein

1981 • 112 citations

The reversible acid dissociation and hybridization of lactic dehydrogenase

1966 • 109 citations

Matrix-bound protein subunits

1970 • 108 citations

Analytical‐Band Centrifugation of an Active Enzyme‐Substrate Complex

1971 • 107 citations

Genetic analysis of the folding pathway for the tail spike protein of phage P22.

1983 • 103 citations

Vom Makromolekül zum biologischen Molekülverband (Nobel‐Vortrag)

1983 • 96 citations

Formation of Randomly Paired Disulfide Bonds in Des-(121–124)-ribonuclease after Reduction and Reoxidation

1970 • 93 citations

Structure, Assembly, and Function of Ribosomes

1982 • 93 citations

The formation of the tertiary structure of proteins.

1967 • 90 citations

Analysis of the reconstitution of oligomeric enzymes by crosslinking with glutaraldehyde: kinetics of reassociation of lactic dehydrogenase

1981 • 89 citations

Tertiary structure of Escherichia coli β-d-galactosidase

1969 • 86 citations

Tobacco Mosaic Virus: Model for Structure and Function of A Simple Virus

1981 • 84 citations

Mobility and recognition in cell biology

1983 • 83 citations

A hypothesis for the pathway of the thermally-induced unfolding of bovine pancreatic ribonuclease

1975 • 82 citations

Guanidine-unfolded state of ribonuclease A contains both fast- and slow-refolding species.

1976 • 82 citations

Reassociation and Reactivation of Lactic Dehydrogenase from the Unfolded Subunits

1974 • 79 citations

Reversible high-pressure dissociation of lactic dehydrogenase from pig muscle

1980 • 74 citations

Quaternary structure, subunit activity, and in vitro association of porcine mitochondrial malic dehydrogenase

1979 • 73 citations

The problem of the stability of globular proteins

1981 • 72 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

Temperature-sensitive mutants blocked in the folding or subunit assembly of the bacteriophage P22 tail spike protein

1981 • 70 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 69 citations

Quaternary Structure of Proteins

1975 • 69 citations

Thermodynamics of Protein-Ligand Interactions: Calorimetric Approaches

1983 • 68 citations

Reactivation of des(119-, 120-, or 121–124) Ribonuclease A by Mixture with Synthetic COOH-terminal Peptides of Varying Lengths

1972 • 67 citations

Reconstitution of lactic dehydrogenase. Noncovalent aggregation vs. reactivation. 2. Reactivation of irreversibly denatured aggregates

1979 • 65 citations

Folding of homologous proteins

1983 • 65 citations

General introduction structure arrangements of macromolecules

1958 • 65 citations

Antibody as an immunological probe for studying the refolding of bovine serum albumin. II. Evidence for the independent refolding of the domains of the molecule.

1976 • 64 citations

Interactions of Water with Nonpolar Solutes

1983 • 63 citations

TEMPERATURE-SENSITIVE MUTANTS BLOCKED IN THE FOLDING OR SUBUNIT ASSMBLY OF THE BACTERIOPHAGE P22 TAILSPIKE PROTEIN. I. FINE-STRUCTURE MAPPING

1980 • 62 citations

Biochemical processes under high hydrostatic pressure

1983 • 61 citations

[61] Immobilized coenzymes

1976 • 60 citations

β-Galactosidase: Immunological Activity of Ribosome-Bound, Growing Polypeptide Chains

1972 • 59 citations

The mechanism of folding of globular proteins. Suitability of a penicillinase from Staphylococcus Aureus as a model for refolding studies

1976 • 59 citations

Kinetics of in vitro reconstitution of oligomeric enzymes by cross-linking

1979 • 57 citations

Antibody as immunological probe for studying refolding of bovine serum albumin. Refolding within each domain.

1977 • 54 citations

Purification of biologically active simian virus 40 small tumor antigen.

1983 • 51 citations

The mechanism of self-assembly of the multi-enzyme complex tryptophan synthase from Escherichia coli.

1984 • 50 citations

Structure of the regular surface layer of Spirillum putridiconchylium

1980 • 46 citations

Solid-phase synthesis of crystalline glucagon

1981 • 46 citations

Dimeric Intermediates in the Dissociation of Lactic Dehydrogenase

1981 • 46 citations

A discussion of pressure-volume effects in aqueous protein solutions

1975 • 45 citations

Folding and association of proteins

1982 • 44 citations

SPECIFICITY IN THE ASSEMBLY OF MULTISUBUNIT PROTEINS

1969 • 44 citations

Mechanism of self-assembly of tobacco mosaic virus protein

1979 • 43 citations

Mechanism of self-assembly of tobacco mosaic virus protein

1979 • 42 citations

The reconstitution of denatured phosphoglycerate mutase.

1983 • 42 citations

Structural molecular biology

1983 • 41 citations

Independent folding regions in aspartokinase-homoserine dehydrogenase

1981 • 41 citations

Refolding and Reactivation of Liver Alcohol Dehydrogenase after Dissociation and Denaturation in 6M Guanidine Hydrochloride

1978 • 40 citations

Effect of Zinc(II) on the Refolding and Reactivation of Liver Alcohol Dehydrogenase

1978 • 39 citations

Limited Proteolysis of Porine‐Muscle Latic Dehydrogenase by Thermolysin during Reconstitution Yields Dimers

1981 • 39 citations

Scanning calorimetric investigation of the polymerization of the coat protein of tobacco mosaic virus

1981 • 38 citations

Immunological study of complementary fragments of β-galactosidase

1974 • 38 citations

Conformational Changes and Proton Uptake in the Reversible Aggregation of Tobacco‐Mosaic‐Virus Protein

1974 • 36 citations

Rate-determining folding and association reactions on reconstitution pathway of porcine skeletal muscle lactic dehydrogenase after denaturation by guanidine hydrochloride

1982 • 36 citations

Folding and association of oligomeric enzymes

1978 • 36 citations

Sequence specificity of trinucleoside diphosphate binding to polymerized tobacco mosaic virus protein

1982 • 36 citations

Pressure-induced structural changes of pig heart lactic dehydrogenase

1981 • 36 citations

Probes of β-galactosidase structure with antibodies. Reaction of antipeptide antibodies against native enzyme

1978 • 35 citations

Kinetics of reconstitution of porcine muscle lactic dehydrogenase after reversible high pressure dissociation

1980 • 34 citations

Proline Isomerization in Unfolded Ribonuclease A

2005 • 34 citations

Determination of hydration and partial specific volume of proteins with the spring balance

1969 • 34 citations

Thermodynamics and mechanism of high-pressure deactivation and dissociation of porcine lactic dehydrogenase

1982 • 34 citations

Refolding and Reactivation of Escherichia coli Tryptophan Synthase β₂ Subunit after Inactivation and Dissociation in Guanidine Hydrochloride at Acidic pH

1978 • 31 citations

Recombination of S-peptide with S-protein during folding of ribonuclease S

1979 • 30 citations

Reconstitution of lactic dehydrogenase from pig heart after reversible high-pressure dissociation

1981 • 29 citations

Reconstitution of the pyruvate dehydrogenase multienzyme complex from Bacillus stearothermophilus

1982 • 29 citations

The dimeric intermediate on the pathway of reconstitution of lactate dehydrogenase is enzymatically active

1983 • 28 citations

Pathways of Assembly of Aspartate Transcarbamoylase from Catalytic and Regulatory Subunits

1974 • 26 citations

Equilibrium and kinetic studies of the association of catalytic and regulatory subunits of aspartate transcarbamoylase.

1980 • 22 citations

Rate enhancement of reconstitution of glyceraldehyde-3-phosphate dehydrogenase by a covalently bound coenzyme analog.

1980 • 20 citations

Measurement of the refolding combination reaction between S-peptide and S-protein

1983 • 20 citations

Purification of Tryptophan Synthase from Saccharomyces cerevisiae and Partial Activity of Its Nicked Subunits

1979 • 20 citations

The Synthesis of Peptides by Solution Methods with Emphasis on Peptide Hormones

1976 • 19 citations

Reconstitution of the isolated β2-subunit of tryptophan synthase from Escherichia coli after dissociation induced by high hydrostatic pressure

1982 • 19 citations

Protein-RNA interactions during the assembly of tobacco mosaic virus

1980 • 19 citations

Influence of Glutathione on the Reactivation of Enzymes Containing Cysteine or Cystine

1983 • 16 citations

Bovine serum albumin as a catalyst. 5. A sensitive assay of the correct refolding of individual fragments of the protein

1976 • 16 citations

A Reversibly Refolding Non-Covalent Complex of Three Peptides from Staphylococcus aureus Penicillinase

1977 • 14 citations

Limited proteolysis as a tool to study the kinetics of protein folding: Conformational rearrangements in acid-dissociated lactic dehydrogenase as determined by pepsin digestion

1983 • 13 citations

The Use of Subunit Hybridization to Monitor the Reassociation of Porcine Lactate Dehydrogenase after Acid Dissociation

1982 • 13 citations

Kinetic analysis of the reconstitution pathway of lactate dehydrogenase using cross-linking with glutaraldehyde

1983 • 12 citations

Genetic and biochemical analysis of in vivo protein folding and subunit assembly

1983 • 11 citations

Tobacco mosaic virus protein: Kinetic and equilibrium studies on the pH-dependent transition A-protein→double disc

1975 • 10 citations

Protein Folding

1980 • 9 citations

Stepwise inactivation of Escherichia coli aspartokinase-homoserine dehydrogenase I

1984 • 9 citations

A contribution to the debate about hydrophobic effects

1978 • 7 citations

Conformational Changes in Protein Antigens Induced by Specific Antibodies: Sperm-whale Myoglobin

1972 • 6 citations

What NAD-Dependent Dehydrogenases Teach Us About the Folding and Association of Oligomeric Proteins

1983 • 5 citations

The Strucure and Assembly of Simple Viruses

1982 • 5 citations