The nuclear pore‐targeting complex binds to nuclear pores after association with a karyophile

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Identification and characterization of a nuclear pore complex protein

1986 • 610 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1991 • 391 citations

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

1992 • 335 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

Pores for thought: nuclear pore complex proteins

1994 • 286 citations

Lipid modification at the N terminus of photoreceptor G-protein α-subunit

1992 • 228 citations

Identification of specific binding proteins for a nuclear location sequence

1989 • 219 citations

Protein import through the nuclear pore complex is a multistep process.

1989 • 208 citations

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.

1992 • 176 citations

A Karyophilic Protein Forms a Stable Complex with Cytoplasmic Components Prior to Nuclear Pore Binding

1995 • 144 citations

Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.

1994 • 114 citations

Loss of RCC1 leads to suppression of nuclear protein import in living cells.

1994 • 109 citations

70-kDa Heat-Shock Cognate Protein Colocalizes with Karyophilic Proteins into the Nucleus during Their Transport in Vitro

1993 • 72 citations

Synthetic peptides containing a region of SV40 large T-antigen involved in nuclear localization direct the transport of proteins into the nucleus

1987 • 61 citations