Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

2008 • 5,528 citations

IDH1andIDH2Mutations in Gliomas

2009 • 5,312 citations

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

2009 • 3,695 citations

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

2009 • 2,156 citations

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

2009 • 1,104 citations

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

2009 • 1,065 citations

Analysis of the IDH1 codon 132 mutation in brain tumors

2008 • 996 citations

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

2009 • 976 citations

Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas

2009 • 960 citations

Chaperone Coexpression Plasmids: Differential and Synergistic Roles of DnaK-DnaJ-GrpE and GroEL-GroES in Assisting Folding of an Allergen of Japanese Cedar Pollen, Cryj2, in Escherichia coli

1998 • 412 citations

Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

2004 • 381 citations

IDH1mutations at residue p.R132 (IDH1^R132) occur frequently in high-grade gliomas but not in other solid tumors

2009 • 355 citations

Minimal residual disease levels assessed by NPM1 mutation–specific RQ-PCR provide important prognostic information in AML

2009 • 323 citations

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

2009 • 297 citations

Overexpression of Trigger Factor Prevents Aggregation of Recombinant Proteins in Escherichia coli

2000 • 290 citations

The effects of three recombinant growth factors, IL-3, GM-CSF, and G- CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension culture

1987 • 215 citations

<scp>l</scp>‐2‐Hydroxyglutaric aciduria, a defect of metabolite repair

2007 • 138 citations

Analysis of IDH1 and IDH2 mutations in Japanese glioma patients

2009 • 137 citations

A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites

2005 • 125 citations

D‐2‐hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats

2003 • 112 citations

<scp>D</scp>‐2‐Hydroxyglutaric aciduria: Unravelling the biochemical pathway and the genetic defect

2006 • 85 citations

Induction of oxidative stress by L‐2‐hydroxyglutaric acid in rat brain

2003 • 67 citations