A Modified Human Tissue Plasminogen Activator with Extended Half–Life In Vivo

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Carbohydrate-Specific Receptors of the Liver

1982 • 1,895 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

On the Regulation and Control of Fibrinolysis

1980 • 1,139 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

1982 • 486 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator.

1982 • 415 citations

Coronary Thrombolysis with Tissue-Type Plasminogen Activator in Patients with Evolving Myocardial Infarction

1984 • 362 citations

Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species.

1984 • 313 citations

Thrombolysis with Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits with Experimental Jugular Vein Thrombosis. EFFECT OF MOLECULAR FORM AND DOSE OF ACTIVATOR, AGE OF THE THROMBUS, AND ROUTE OF ADMINISTRATION

1983 • 249 citations

Clot-Selective Coronary Thrombolysis with Tissue-Type Plasminogen Activator

1983 • 243 citations

On the interaction of the finger and the kringle-2 domain of tissue-type plasminogen activator with fibrin. Inhibition of kringle-2 binding to fibrin by epsilon-amino caproic acid.

1986 • 239 citations

Autonomous functions of structural domains on human tissue-type plasminogen activator.

1986 • 226 citations

Turnover of Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits

1981 • 184 citations

Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences

1984 • 176 citations

Thrombolysis with human extrinsic (tissue-type) plasminogen activator in dogs with femoral vein thrombosis.

1982 • 160 citations

Analysis of coagulation and fibrinolysis during intravenous infusion of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction.

1986 • 154 citations

Pharmacokinetics and systemic fibrinogenolytic effects of recombinant human tissue-type plasminogen activator (rt-PA) in humans.

1985 • 149 citations

SPECIFIC LYSIS OF AN ILIOFEMORAL THROMBUS BY ADMINISTRATION OF EXTRINSIC (TISSUE-TYPE) PLASMINOGEN ACTIVATOR

1981 • 146 citations

Biological properties of human tissue-type plasminogen activator obtained by expression of recombinant DNA in mammalian cells.

1984 • 140 citations

Coronary thrombolysis with recombinant human tissue-type plasminogen activator.

1984 • 136 citations

The sulphite precipitation method for fibrinogen measurement; Its use on small samples in the presence of fibrinogen degradation products

1976 • 114 citations

Catabolism of human tissue plasminogen activator in mice

1985 • 108 citations

Thrombolysis with human extrinsic (tissue-type) plasminogen activator in rabbits with experimental jugular vein thrombosis

1983 • 103 citations

Localization of the binding site of tissue-type plasminogen activator to fibrin.

1986 • 91 citations

Hepatic Clearance of Tissue-Type Plasminogen Activator in Rats

1985 • 88 citations

Structure and function of human tissue‐type plasminogen activator (t‐PA)

1986 • 85 citations

Failure of transdermal nitroglycerin to improve exercise capacity in patients with angina pectoris

1985 • 82 citations

Systemic thrombolytic therapy of acute myocardial infarction?

1983 • 80 citations

Pharmacokinetics and Effects on Fibrinolytic and Coagulation Parameters of Two Doses of Recombinant Tissue-Type Plasminogen Activator in Healthy Volunteers

1986 • 72 citations

Expression in E. coli of finger‐domain lacking tissue‐type plasminogen activator with high fibrin affinity

1985 • 71 citations

Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.

1983 • 71 citations

Coronary thrombolysis and infarct size reduction after intravenous infusion of recombinant tissue-type plasminogen activator in nonhuman primates.

1985 • 70 citations

Isolation and functional characterization of the heavy and light chains of human tissue-type plasminogen activator.

1986 • 67 citations

Clearance of the heavy and light polypeptide chains of human tissue-type plasminogen activator in rats

1986 • 58 citations

Turnover of tissue plasminogen activator in normal and hepatectomized rabbits

1985 • 58 citations

Plasminogen assay in rabbit, rat and mouse plasma using the chromogenic substrate S-2251

1979 • 50 citations

Monoclonal antibody that specifically inhibits a human M _r 52,000 plasminogen-activating enzyme

1982 • 45 citations

Functional properties of carbohydrate-depleted tissue plasminogen activator

1984 • 42 citations

Efficient production of hepatitis B surface antigen using a bovine papilloma virus-metallothionein vector.

1984 • 38 citations

Functional analysis of the human tissue-type plasminogen activator protein: the light chain

1986 • 37 citations

Influence of fibrin and liver blood flow on the turnover and the systemic fibrinogenolytic effects of recombinant human tissue-type plasminogen activator in rabbits

1986 • 35 citations

On the Composition and Function of the Carbohydrate Moiety of Tissue-Type Plasminogen Activator from Human Melanoma Cells

1985 • 33 citations

Thrombolysis with recombinant tissue plasminogen activator in atherosclerotic thrombotic occlusion

1985 • 28 citations

Determinants of clearance of tissue-type plasminogen activator (t-PA) from the circulation

1987 • 28 citations

Coronary thrombolysis with tissue-type plasminogen activator (t-PA): Emerging strategies

1986 • 20 citations

Turnover of Tissue Plasminogen Activator in Man

1982 • 16 citations

Species specificity in the acceleration of tissue-type plasminogen activator-mediated activation of plasminogens, by fibrinogen cyanogen bromide fragments

1985 • 13 citations

Advances in clinical fibrinolysis.

1986 • 11 citations

8 Advances in Clinical Fibrinolysis

1986 • 10 citations

Chapter 11. Plasminogen Activators

1985 • 3 citations

Construction and analysis of bovine papilloma virus vectors for the expression of tissue plasminogen activator in mouse cells

1986 • 2 citations