Behavioral and physiological effects of xanthines in nonhuman primates

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Adenosine receptors: targets for future drugs

1982 • 681 citations

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

1992 • 649 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Tolerance to the humoral and hemodynamic effects of caffeine in man.

1981 • 507 citations

Regulatory Function of Adenosine

1983 • 454 citations

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells

1993 • 445 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Clinical Pharmacology of Caffeine

1990 • 417 citations

Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions

1994 • 395 citations

Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.

1982 • 393 citations

Adenosine-dopamine interactions in the brain

1992 • 366 citations

Caffeine - Its Identity, Dietary Sources, Intake and Biological Effects

2009 • 325 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Brain adenosine concentration during hypoxia in rats

1981 • 299 citations

Caffeine physical dependence: a review of human and laboratory animal studies

1988 • 282 citations

Variability in caffeine metabolism

1983 • 255 citations

A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug Selectivity

1985 • 248 citations

Mammalian cytochromes P-450

1987 • 248 citations

EFFECTS OF CAFFEINE ON MAMMALIAN ATRIAL MUSCLE, AND ITS INTERACTION WITH ADENOSINE AND CALCIUM.

1965 • 242 citations

Caffeine Use as a Model of Acute and Chronic Insomnia

1992 • 232 citations

Prevention of Apnea and Bradycardia in Low-Birthweight Infants

1975 • 217 citations

Cyclic Nucleotide Phosphodiesterases: Properties, Activators, Inhibitors, Structure–Activity Relationships, and Possible Role in Drug Development

1975 • 206 citations

Relationship between adenosine concentration and oxygen supply in rat brain

1975 • 202 citations

Caffeine and theophylline analogues: Correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors

1988 • 194 citations

Predicting the Abuse Liability of Drugs with Animal Drug Self-Administration Procedures: Psychomotor Stimulants and Hallucinogens

1979 • 190 citations

Apnoeic attacks in the newborn treated with aminophylline.

1973 • 176 citations

Drugs used in the treatment of asthma

1990 • 175 citations

Effects of caffeine on alertness

1990 • 171 citations

Interspecies Comparison of In Vivo Caffeine Pharmacokinetics in Man, Monkey, Rabbit, Rat and Mouse

1984 • 170 citations

Human Consumption of Caffeine

1984 • 164 citations

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

1986 • 156 citations

Caffeine tolerance and choice in humans

1992 • 151 citations

Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior.

1989 • 149 citations

Human coffee drinking: reinforcing and physical dependence producing effects of caffeine.

1986 • 147 citations

3,7-Dimethyl-1-propargylxanthine: A potent and selective in vivo antagonist of adenosine analogs

1988 • 141 citations

Interactions in the behavioral effects of methylxanthines and adenosine derivatives.

1983 • 128 citations

Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes

1992 • 119 citations

Adenosine receptors mediating cardiac depression

1982 • 115 citations

Dose-dependency of caffeine metabolism with repeated dosing

1990 • 112 citations

Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.

1987 • 112 citations

Role of adenosine receptors in caffeine tolerance.

1991 • 111 citations

Reinforcing properties of caffeine: Studies in humans and laboratory animals

1988 • 110 citations

Ligand selectivity of dog coronary adenosine receptor resembles that of adenylate cyclase stimulatory (Ra) receptors.

1983 • 110 citations

Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine

1986 • 104 citations

Tolerance to caffeine-induced stimulation of locomotor activity in rats.

1986 • 100 citations

Coronary vasoactivity of adenosine in the conscious dog.

1979 • 99 citations

Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA).

1975 • 99 citations

Complete, reversible, drug-specific tolerance to stimulation of locomotor activity by caffeine

1983 • 98 citations

Physiologic changes induced by theophylline in the treatment of apnea in preterm infants

1978 • 98 citations

Analogs of caffeine: Antagonists with selectivity for A2 adenosine receptors

1986 • 96 citations

Adenosine stimulates respiration in man.

1985 • 95 citations

Tolerance to behavioral effects of caffeine in rats

1988 • 94 citations

EFFECTS OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON SCHEDULED CONTROLLED RESPONDING IN RATS

1982 • 93 citations

On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat

1983 • 93 citations

EFFECTS OF INHALATION OF 100 PER CENT AND 14 PER CENT OXYGEN UPON RESPIRATION OF UNANESTHETIZED DOGS BEFORE AND AFTER CHEMORECEPTOR DENERVATION

1943 • 92 citations

Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease

1982 • 90 citations

Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double‐blind crossover study.

1983 • 87 citations

Effect of Aminophylline on Respiratory Center Activity and Metabolic Rate in Premature Infants With Idiopathic Apnea

1979 • 86 citations

Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline.

1987 • 74 citations

Circulatory and respiratory effects of infused adenosine in conscious man.

1987 • 73 citations

Adenosine mechanisms in the regulation of breathing in the rat

1984 • 67 citations

Neuromodulators and transmitters in respiratory control.

1986 • 67 citations

Prolonged inhibition of respiration following acute hypoxia in glomectomized cats

1984 • 66 citations

Caffeine as a model drug of abuse

1990 • 63 citations

Pharmacologic specificity of tolerance to caffeine-induced stimulation of locomotor activity

1987 • 61 citations

Effects of drugs of abuse and cholinergic agents on delayed matching-to-sample responding in the squirrel monkey.

1993 • 58 citations

Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.

1987 • 58 citations

Seizure activity in animals given enprofylline and theophylline, two xanthines with partly different mechanisms of action.

1982 • 56 citations

Action of Caffeine and Aminophylline as Respiratory Stimulants in Man

1949 • 53 citations

Dissociation of the locomotor and hypotensive effects of adenosine analogues in the rat

1984 • 51 citations

Caffeine cross-tolerance to selective dopamine D1 and D2 receptor agonists but not to their synergistic interaction

1994 • 51 citations

Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: Evaluation of structure-activity relationships

1982 • 47 citations

Products of Metabolism of Caffeine

1984 • 45 citations

Caffeine Reinforcement, Discrimination, Tolerance and Physical Dependence in Laboratory Animals and Humans

1996 • 45 citations

Cross-tolerance studies between caffeine and (−)-N6-(phenylisopropyl)-adenosine (PIA) in mice

1986 • 44 citations

Central nervous system pharmacology of the dietary methylxanthines.

1984 • 43 citations

Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism

1988 • 42 citations

Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio‐respiratory stimulation of infused adenosine in man

1987 • 41 citations

Behavioural effects of anxiogenic agents in the common marmoset

1992 • 40 citations

The Cardiovascular Effects of Caffeine

1984 • 39 citations

A potent and selective inhibitor of cyclic AMP phosphodiesterase with potential cardiotonic and antithrombotic properties.

1986 • 39 citations

Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.

1988 • 37 citations

Behavioral effects of adenosine analogs in squirrel monkeys: relation to adenosine A2 receptors

1986 • 37 citations

Cyclic Nucleotides in the Central Nervous System

1980 • 36 citations

Effects of drugs of abuse on acquisition of behavioral chains in squirrel monkeys

1992 • 35 citations

Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys.

1987 • 35 citations

Cardiovascular actions of substituted adenosine analogues

1971 • 34 citations

Aminophylline Therapy for Idiopathic Apnea in Premature Infants: Effects on Lung Function

1978 • 32 citations

Behavioral dependence on caffeine and phencyclidine in rhesus monkeys: Interactive effects

1988 • 32 citations

Hemodynamic effects of adenosine in conscious hypertensive and normotensive rats.

1986 • 32 citations

The effect of caffeine, theophylline and amphetamine on operant responding of the mouse

1980 • 31 citations

Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys.

1993 • 31 citations

Evidence That a Novel 8-Phenyl-Substituted Xanthine Derivative is a Cardioselective Adenosine Receptor Antagonist In Vivo

1987 • 30 citations

Acute effects of caffeine on several operant behaviors in rhesus monkeys

1993 • 30 citations

Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors.

1981 • 29 citations

Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys.

1985 • 29 citations

Evidence that the positive inotropic effects of the alkylxanthines are not due to adenosine receptor blockade

1984 • 29 citations

Selective effects of adenosine receptor agonists upon coronary resistance and heart rate in isolated working rabbit hearts

1985 • 26 citations

Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites

1984 • 26 citations

Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys

1978 • 25 citations

Stereoselective behavioral effects of N6-phenylisopropyl-adenosine and antagonism by caffeine

1985 • 24 citations

Separation of vasodilator and negative chronotropic actions in analogues of adenosine

1972 • 20 citations

Psychomotor stimulant effects of caffeine alone and in combination with an adenosine analog in the squirrel monkey.

1987 • 20 citations

Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys

1995 • 17 citations

Respiratory effects of xanthines and adenosine analogs in rhesus monkeys.

1990 • 17 citations

Effects of theophylline on adenosine-induced respiratory depression in the preterm rabbit.

1984 • 17 citations

Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats

1988 • 16 citations

Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: Comparison with caffeine and 7-(2-chloroethyl) theophylline

1989 • 15 citations

Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys.

1993 • 15 citations

Theophylline effect upon respiration and ventilation in the dog: interaction with methadone.

1981 • 14 citations

ON THE PHARMACOLOGY OF THE RESPIRATORY CENTRE

1913 • 14 citations

Effects of caffeine on ventilation during acute and chronic nicotine administration in rhesus monkeys.

1995 • 13 citations

Automated behavioral procedures for infant monkeys

1990 • 12 citations

Effects of CGS 15943, a nonxanthine adenosine antagonist, on behavior in the squirrel monkey.

1993 • 11 citations

Behavioral effects of d-amphetamine and caffeine in the squirrel monkey

1975 • 11 citations

Comparison of respiratory effects of intravenous adenosine in neonatal and adult rabbits

1986 • 10 citations

The Role of Adenosine in Respiratory Physiology

1990 • 9 citations

Effects of adenosine analogs alone and in combination with caffeine in the squirrel monkey

1988 • 9 citations

A study of the cardiovascular actions of 2-chloroadenosine.

1959 • 8 citations

Effects of methylxanthines on skeletal muscle and on respiration.

1984 • 6 citations

Oxygen and Theophylline Reduce the Cardiorespiratory Effects of Adenosine Infusion in Han

1987 • 4 citations

BEHAVIORAL AND PHARMACOLOGICAL MODULATION OF RESPIRATION IN RHESUS MONKEYS

1994 • 2 citations