High cholesterol affects platelet APP processing in controls and in AD patients

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Statins and the risk of dementia

2000 • 1,741 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1997 • 1,380 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 • 984 citations

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

2001 • 788 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Plasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer Disease

2000 • 564 citations

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

2001 • 516 citations

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

2001 • 462 citations

A detergent-insoluble membrance compartment contains Aβ in vivo

1998 • 394 citations

The role of cholesterol in the biosynthesis of β-amyloid.

1999 • 326 citations

Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma

1996 • 316 citations

Standardization of measurement of β-amyloid_(1-42)in cerebrospinal fluid and plasma

2000 • 301 citations

Platelets Are the Primary Source of Amyloid β-Peptide in Human Blood

1995 • 295 citations

Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol

1998 • 252 citations

α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients

2002 • 229 citations

Differential Level of Platelet Amyloid beta Precursor Protein Isoforms: An Early Marker for Alzheimer Disease

1998 • 141 citations

Altered Amyloid Protein Processing in Platelets of Patients With Alzheimer Disease

1997 • 127 citations

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

1999 • 119 citations

Platelet APP isoform ratios correlate with declining cognition in AD

2000 • 106 citations

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

2000 • 96 citations

Amyloid precursor protein in platelets

2001 • 90 citations

Cholesterol, Aβ and Alzheimer's disease

2001 • 47 citations

Peripheral Blood Abnormalities in Alzheimer Disease: Evidence for Early Endothelial Dysfunction

2002 • 38 citations

β amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: Usage of a novel blood brain barrier endothelial cell model system

2000 • 30 citations

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

2000 • 29 citations