Altered Amyloid Protein Processing in Platelets of Patients With Alzheimer Disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Reduction of β‐amyloid peptide₄₂ in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 684 citations

Isoform-specific binding of apolipoprotein E to beta-amyloid.

1994 • 529 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

The amyloid precursor protein of Alzheimer's disease is released by human platelets.

1990 • 322 citations

Platelets Are the Primary Source of Amyloid β-Peptide in Human Blood

1995 • 295 citations

Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease

1996 • 255 citations

Non-age Related Differences in Thrombin Responses by Platelets from Male Patients with Advanced Alzheimer′s Disease

1993 • 226 citations

Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 223 citations

Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet

1994 • 125 citations

Family Study of Platelet Membrane Fluidity in Alzheimer's Disease

1987 • 108 citations

Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage

1994 • 107 citations

Abnormal Pattern of Platelet APP Isoforms in Alzheimer Disease and Down Syndrome

1996 • 78 citations

Stimulated platelets release amyloid β-protein precursor

1990 • 76 citations

Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA

1990 • 74 citations

Cytokines in Alzheimer's disease and multiple sclerosis

1995 • 65 citations

Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytes

1992 • 61 citations

An abnormality of plasma amyloid protein precursor in Alzheimer's disease

1992 • 58 citations

β-Amyloid Protein Induces Platelet Aggregation and Supports Platelet Adhesion

1994 • 49 citations

A causal role for amyloid in Alzheimer's disease

1993 • 31 citations

Platelet Protein Kinase C levels in Alzheimer's disease

1994 • 27 citations

Experiences with depression in a dementia clinic.

1991 • 25 citations

Reduction of platelet phospholipase C activity in patients with Alzheimer disease.

1995 • 20 citations

Platelets from patients with Alzheimer's disease or other dementias exhibit disease-specific and apolipoprotein E correlatable defects

1996 • 12 citations

Relevanz des Metabolismus der Membranphospholipide für die Alzheimer-Demenz

1996 • 6 citations