Epibatidine and pain

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

1995 • 1,017 citations

Neurotransmitters in Nociceptive Modulatory Circuits

1991 • 970 citations

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

1992 • 465 citations

Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation

1992 • 328 citations

Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors.

1995 • 284 citations

Nicotinic binding sites in rat and mouse brain: comparison of acetylcholine, nicotine, and alpha-bungarotoxin.

1986 • 262 citations

Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

1995 • 258 citations

Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.

1995 • 194 citations

Potentiation of nicotinic receptor response by external calcium in rat central neurons

1992 • 191 citations

Antinociceptive effects of central and systemic administrations of nicotine in the rat

1979 • 181 citations

Pharmacology of Neuronal Nicotinic Acetylcholine Receptor Subtypes

1997 • 179 citations

Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels.

1982 • 171 citations

Epibatidine is a nicotinic analgesic

1993 • 168 citations

(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.

1994 • 166 citations

Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors

1994 • 162 citations

Electrophysiological effects of nicotine

1981 • 129 citations

Nicotine as a psychoactive drug: anxiety and pain reduction.

1986 • 117 citations

Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptors

1983 • 102 citations

Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay

1996 • 97 citations

Pharmacological effects of epibatidine optical enantiomers

1994 • 94 citations

Nicotine-induced release of catecholamines from rat hippocampus and striatum

1978 • 93 citations

Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine

1997 • 92 citations

Recent Developments in the Study of the Effects of Cigarette Smoking on Clinical Pharmacokinetics and Clinical Pharmacodynamics

1989 • 91 citations

A versatile total synthesis of epibatidine and analogs

1993 • 84 citations

Antinociceptive action of nicotine and its methiodide derivatives in mice and rats

1983 • 73 citations

Total synthesis of epibatidine

1993 • 68 citations

The synthesis of (+)- and (–)-epibatidine

1993 • 68 citations

Expression of ganglia-type nicotinic acetylcholine receptors and nicotinic ligand binding sites by cells of the IMR-32 human neuroblastoma clonal line.

1993 • 61 citations

Epibatidine binding sites and activity in the spinal cord

1997 • 60 citations

Antinociceptive and toxic effects of (+)‐epibatidine oxalate attributable to nicotinic agonist activity

1994 • 57 citations

Entry and distribution of hexamethonium in the central nervous system

1971 • 55 citations

Involvement of calcium and L-type channels in nicotine-induced antinociception.

1993 • 54 citations

Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

1997 • 53 citations

Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.

1990 • 47 citations

Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats

1990 • 47 citations

Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats.

1996 • 47 citations

Smoking, pain tolerance, and physiological activation

1983 • 30 citations

Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice

1996 • 24 citations

Frog Venom Cocktail Yields a One-Handed Painkiller

1993 • 23 citations

Resolution of Synthetic (+)- and (-)-Epibatidine by Chiral High Performance Liquid Chromatography and Identification of the Natural Enantiomer

1994 • 14 citations

A PRELIMINARY STUDY ON PAIN PERCEPTION AND TOBACCO SMOKING

1983 • 14 citations

Mechanisms of Drugs in Anaesthesia

1993 • 10 citations