Diminished Primary and Secondary Influenza Virus-Specific CD8⁺T-Cell Responses in CD4-Depleted Ig^−/−Mice

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Roles of alphabeta and gammadelta T Cell Subsets in Viral Immunity

1992 • 350 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

Clearance of an Influenza A Virus by CD4⁺T Cells Is Inefficient in the Absence of B Cells

1998 • 169 citations

Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.

1996 • 157 citations

In vivoproliferation of naïve and memory influenza-specific CD8⁺T cells

1999 • 146 citations

CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice

1991 • 129 citations

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

1998 • 129 citations

Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.

1995 • 118 citations

Prevalent Class I-Restricted T-Cell Response to the Theiler’s Virus Epitope D^b:VP2_121–130in the Absence of Endogenous CD4 Help, Tumor Necrosis Factor Alpha, Gamma Interferon, Perforin, or Costimulation through CD28

1999 • 114 citations

Virus-specific CD8⁺T cell numbers are maintained during γ-herpesvirus reactivation in CD4-deficient mice

1998 • 105 citations

A pulmonary influenza virus infection in SCID mice can be cured by treatment with hemagglutinin-specific antibodies that display very low virus-neutralizing activity in vitro

1997 • 102 citations

CD4+T Cells Are Ineffective in Clearing a Pulmonary Infection with Influenza Type A Virus in the Absence of B Cells

1997 • 87 citations

Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses

1994 • 80 citations

Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins

1995 • 65 citations

Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium lonophore

1988 • 60 citations

Protection against a Lethal Avian Influenza A Virus in a Mammalian System

1999 • 54 citations