Oxidative Modification to Cysteine Sulfonic Acid of Cys111 in Human Copper-Zinc Superoxide Dismutase

Superoxide Dismutase

1969 • 12,578 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

2003 • 1,622 citations

From charcot to lou gehrig: deciphering selective motor neuron death in als

2001 • 1,373 citations

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1998 • 1,207 citations

Determination and analysis of the 2 Å structure of copper, zinc superoxide dismutase

1982 • 932 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Peroxiredoxin, a Novel Family of Peroxidases

2001 • 616 citations

Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis

2000 • 604 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Misfolded CuZnSOD and amyotrophic lateral sclerosis

2003 • 542 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Inactivation of Human Peroxiredoxin I during Catalysis as the Result of the Oxidation of the Catalytic Site Cysteine to Cysteine-sulfinic Acid

2002 • 449 citations

Amyotrophic Lateral Sclerosis

2001 • 437 citations

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

2006 • 419 citations

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

2004 • 375 citations

Oxidation-induced Misfolding and Aggregation of Superoxide Dismutase and Its Implications for Amyotrophic Lateral Sclerosis

2002 • 323 citations

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins

2004 • 310 citations

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.

1992 • 299 citations

Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases

2005 • 280 citations

Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH

2000 • 271 citations

Amyotrophic Lateral Sclerosis Mutations Have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation

2005 • 263 citations

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials

2006 • 250 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Chemiluminescence and peroxidation

1975 • 249 citations

Wild‐type superoxide dismutase acquires binding and toxic properties of ALS‐linked mutant forms through oxidation

2007 • 245 citations

Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation.

1990 • 242 citations

Site-specific and random fragmentation of Cu,Zn-superoxide dismutase by glycation reaction. Implication of reactive oxygen species.

1992 • 227 citations

Molecular Evolution and Structure–Function Relationships of the Superoxide Dismutase Gene Families in Angiosperms and Their Relationship to Other Eukaryotic and Prokaryotic Superoxide Dismutases

2002 • 226 citations

Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

2006 • 220 citations

Identification of oxidized histidine generated at the active site of Cu,Zn-superoxide dismutase exposed to H2O2. Selective generation of 2-oxo-histidine at the histidine 118.

1994 • 214 citations

Evolution of CuZn superoxide dismutase and the Greek Key β‐barrel structural motif

1989 • 208 citations

Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis

2006 • 206 citations

Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection

1997 • 202 citations

Untitled

2002 • 180 citations

Contribution of conformational stability and reversibility of unfolding to the increased thermostability of human and bovine superoxide dismutase mutated at free cysteines.

1990 • 136 citations

The sulfinic acid switch in proteins

2004 • 135 citations

Extensive Investigations on Oxidized Amino Acid Residues in H₂O₂-Treated Cu,Zn-SOD Protein with LC-ESI-Q-TOF-MS, MS/MS for the Determination of the Copper-Binding Site

2001 • 112 citations

Bicarbonate-dependent Peroxidase Activity of Human Cu,Zn-Superoxide Dismutase Induces Covalent Aggregation of Protein

2003 • 108 citations

Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice

2006 • 97 citations

Copper(2+) Binding to the Surface Residue Cysteine 111 of His46Arg Human Copper−Zinc Superoxide Dismutase, a Familial Amyotrophic Lateral Sclerosis Mutant

2000 • 89 citations

Modification of cysteine 111 in Cu/Zn superoxide dismutase results in altered spectroscopic and biophysical properties

2004 • 81 citations

Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines

1991 • 77 citations

Reactions of Hydrogen Peroxide with Familial Amyotrophic Lateral Sclerosis Mutant Human Copper-Zinc Superoxide Dismutases Studied by Pulse Radiolysis

1998 • 62 citations

Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models

2005 • 53 citations

Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis

2007 • 51 citations

Structure, molecular evolution, and gene expression of primate superoxide dismutases

2002 • 50 citations

Physicochemical Properties of Charge Isomers of Recombinant Human Superoxide Dismutase

1988 • 26 citations

Modification of Cysteine 111 in human Cu,Zn-superoxide dismutase

2006 • 22 citations

Comparison of Properties between Human Recombinant and Placental Copper-Zinc SOD

1988 • 18 citations

Different Immunoreactivity against Monoclonal Antibodies between Wild-type and Mutant Copper/Zinc Superoxide Dismutase Linked to Amyotrophic Lateral Sclerosis

2004 • 11 citations

Characterisation of the chicken Cu, Zn superoxide dismutase gene

1996 • 6 citations