Binding of the Adenosine A2 Receptor Ligand [3H]CGS 21680 to Human and Rat Brain: Evidence for Multiple Affinity Sites

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

The Physiological Role of Adenosine In The Central Nervous System

1985 • 628 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

1989 • 537 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine

1982 • 417 citations

The distribution of adenosine a1 receptors and 5'-nucleotidase in the brain of some commonly used experimental animals

1987 • 322 citations

Purine Receptors in Mammalian Tissues: Pharmacology and Functional Significance

1987 • 302 citations

Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor

1986 • 284 citations

CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

1989 • 245 citations

The role of purines in nociception

1989 • 198 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Adenosine A1 receptors in the human brain: A quantitative autoradiographic study

1987 • 137 citations

Adenosine: The prototypic neuromodulator

1989 • 127 citations

Characterization and localization of adenosine receptors in rat spinal cord

1984 • 122 citations

Adenosine receptors in fat cells. Identification by (-)-N6-[3H]phenylisopropyladenosine binding.

1981 • 118 citations

[3H]5?-N-ethylcarboxamide adenosine binds to both Ra and Ri adenosine receptors in rat striatum

1984 • 110 citations

On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat

1983 • 106 citations

Modulation of Striatal Dopaminergic Function by Local Injection of 5′- N -Ethylcarboxamide Adenosine

1982 • 104 citations

Adenosine receptors in the nervous system

1989 • 102 citations

Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice

1989 • 101 citations

PD 115,199: An antagonist ligand for adenosine A2 receptors

1987 • 96 citations

Autoradiographic characterization of high-affinity adenosine A2 receptors in the rat brain

1989 • 94 citations

Inhibition of brain adenylate cyclase by A1 adenosine receptors: Pharmacological characteristics and locations

1983 • 81 citations

Adenosine-sensitive adenylate cyclase in rat brain homogenates: kinetic characteristics, specificity, topographical, subcellular and cellular distribution.

1979 • 78 citations

1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N-ethylcar☐amidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors

1986 • 71 citations

Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration

1988 • 70 citations

Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain

1989 • 70 citations

Discrete Distributions of Adenosine Receptors in Mammalian Retina

1990 • 66 citations

Species differences in high‐affinity adenosine A₂ binding sites in striatal membranes from mammalian brain

1988 • 60 citations

Desensitization of adenosine and dopamine receptors in rat brain after treatment with adenosine analogs.

1988 • 47 citations

Decrease in rat straital dopamine synthesis and metabolism in vivo by metabolically stable adenosine receptor agonists

1986 • 45 citations

Activation of adenylate cyclase from rat striatum and tuberculum olfactorium by adenosine.

1977 • 43 citations

Adenosine Deaminase and [3H] Nitrobenzylthioinosine as Markers of Adenosine Metabolism and Transport in Central Purinergic Systems

1990 • 42 citations

Phylogenetic distribution of [3H]cyclohexyladenosine binding sites in nervous tissue

1986 • 39 citations

A selective binding site for 3H-NECA that is not an adenosine A2 receptor

1989 • 35 citations

Heterogeneity of binding sites for N-ethylcar☐amido[3H]adenosine in rat brain: Effects of N-ethylmaleimide

1986 • 34 citations

Adenosine modulation of striatal neurotransmitter release monitored in vivo using voltammetry

1986 • 31 citations

Adenosine and dopamine function in the CNS

1987 • 31 citations

Differences in adenosine A-1 and A-2 receptor density revealed by autoradiography in methylxanthine-sensitive and insensitive mice

1988 • 26 citations

5′-N-ethylcarboxamido[8-3H]adenosine binds to two different adenosine receptors in membranes from the cerebral cortex of the rat

1988 • 25 citations

Summary of a Symposium Discussion on Purine Receptor Nomenclature

1985 • 22 citations

Evidence for an A2 adenosine receptor in guinea pig lung

1985 • 21 citations

Some properties of a purinergic receptor solubilized from human uterus membranes

1984 • 16 citations

Autoradiographic demonstration of peripheral adenosine binding sites using [3H]NECA

1983 • 13 citations

Characterization of 5′-N ethylcarboxamido[3H]adenosine binding to pig aorta smooth muscle membranes

1987 • 13 citations

Adenosine: A Molecule for Synaptic Homeostasis?

1988 • 13 citations

Distinct adenosine deaminase-containing inputs to the substantia nigra from the striatum and tuberomammillary nucleus

1988 • 12 citations

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