Detection of a tetrahedral intermediate in the trypsin-catalysed hydrolysis of specific ring-activated anilides

Physical organic chemistry

1956 • 1,987 citations

p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin

1967 • 848 citations

Mechanism of Action of Proteolytic Enzymes

1965 • 473 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Physical Organic Chemistry

1960 • 284 citations

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin

1973 • 191 citations

Investigations of the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates

1967 • 95 citations

Mechanism of action of serine proteases: tetrahedral intermediate and concerted proton transfer

1976 • 93 citations

Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relations

1973 • 80 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of amides. pH dependence of kc and km. kinetic detection of an intermediate

1971 • 68 citations

Chymotrypsin catalysis. Evidence for a new intermediate

1969 • 54 citations

Participation of an Acidic Group in the Chymotrypsin Catalysis***

1969 • 43 citations

Use of N-benzoyl-L-tyrosine thiobenzyl ester as a protease substrate. Hydrolysis by alpha-chymotrypsin and subtilisin BPN.

1975 • 40 citations

Nitrogen isotope effects on the papain-catalyzed hydrolysis of N-benzoyl-L-argininamide

1974 • 34 citations

Mechanism of reaction of human plasmin with

1974 • 15 citations

Structure‐Activity Relationship in the Urokinase Hydrolysis of α‐N‐Acetyl‐<scp>l</scp>‐lysine Anilides

1975 • 10 citations

Some evidence for the existence of two non-covalent complexes before the acylation step during the tryptic hydrolysis of Benzoyl-Arginine para-Nitroanilide

1966 • 6 citations