Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

The Atlas of Mouse Development

1992 • 1,782 citations

The atlas of mouse development

1993 • 1,427 citations

Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products

1991 • 1,182 citations

Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes

1988 • 963 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

The human alkaline phosphatases: What we know and what we don't know

1990 • 503 citations

Hypophosphatasia and the Role of Alkaline Phosphatase in Skeletal Mineralization*

1994 • 470 citations

α-FETOPROTEIN IN INDIAN CHILDHOOD CIRRHOSIS

1974 • 409 citations

Mice lacking tissue non–specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B–6

1995 • 391 citations

Alkaline Phosphatase

1979 • 371 citations

A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia.

1988 • 326 citations

A SPECIFIC WATER DIURESIS TEST FOR ADRENOCORTICAL INSUFFICIENCY

1953 • 281 citations

Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.

1992 • 250 citations

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.

1990 • 241 citations

Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.

1985 • 214 citations

Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells

1995 • 212 citations

Clinical autonomic disorders : evaluation and management

1997 • 190 citations

Mikroskopische Technik

1949 • 168 citations

Hypoaminotransferasemia in patients undergoing long-term hemodialysis: Clinical and biochemical appraisal

1995 • 152 citations

Two alkaline phosphatase genes are expressed during early development in the mouse embryo

1990 • 149 citations

Clinical Autonomic Disorders: Evaluation and Management

1993 • 144 citations

Adult hypophosphatasia. Clinical, laboratory, and genetic investigation of a large kindred with review of the literature.

1979 • 141 citations

Hypophosphatasia

1984 • 120 citations

Adult Hypophosphatasia

1979 • 117 citations

Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.

1988 • 107 citations

Hypophosphatasia

1976 • 100 citations

Adult hypophosphatasia with chondrocalcinosis and arthropathy

1982 • 100 citations

Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study.

1990 • 96 citations

Perinatal lethal hypophosphatasia; Clinical, radiologic and morphologic findings

1991 • 90 citations

Missense Mutations of the Tissue-Nonspecific Alkaline Phosphatase Gene in Hypophosphatasia

1992 • 86 citations

PYRIDOXINE DEFICIENCY IN THE NEONATAL RAT

1969 • 83 citations

AUTONOMIC NEUROPATHY OF ACUTE ONSET

1974 • 79 citations

Isolation and characterization of the mouse liver/bone/kidney-type alkaline phosphatase gene

1990 • 70 citations

Vagal control of lymphocyte release from rat thymus

1994 • 68 citations

Stage‐specific expression of alkaline phosphatase during neural development in the mouse

1994 • 67 citations

Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes

1990 • 66 citations

Oncodevelopmental expression and structure of alkaline phosphatase genes.

1988 • 65 citations

Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse

1992 • 40 citations

Serum alkaline phosphatase in hypophosphatasia

1971 • 40 citations

Hypophosphatasia (adult form): quantitation of serum alkaline phosphatase isoenzyme activity in a large kindred.

1980 • 36 citations

DEGENERATION OF THE AUTONOMIC NERVOUS SYSTEM

1971 • 35 citations

Phenotypically dissimilar hypophosphatasia in two sibships

1992 • 31 citations

Hypophosphatasia (adult form): quantitation of serum alkaline phosphatase isoenzyme activity in a large kindred.

1980 • 28 citations

Preimplantation Mouse Embryos Express a Heat-Stable Alkaline Phosphatase1

1989 • 24 citations

INFANTILE CONVULSION SUSPECTED OF PYRIDOXINE RESPONSIVE SEIZURES

1978 • 16 citations

Progressive myoclonic epilepsy, nerve deafness and spinal muscular atrophy.

1984 • 15 citations

Cloning and characterization of a cDNA encoding alkaline phosphatase in mouse embryonal carcinoma cells

1990 • 13 citations

Rapid phage DNA isolation without the use of enzymes.

1988 • 11 citations