Presenilin 1 in migration and morphogenesis in the central nervous system

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Neurons derived from radial glial cells establish radial units in neocortex

2001 • 1,932 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 • 1,253 citations

Rho GTPases and cell migration

2001 • 1,170 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

A decade of CDK5

2001 • 1,027 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

A long, remarkable journey: Tangential migration in the telencephalon

2001 • 1,017 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

C<scp>ELL</scp>M<scp>IGRATION IN THE</scp>F<scp>OREBRAIN</scp>

2003 • 917 citations

Development of the Cerebellar System: In Relation to Its Evolution, Structure, and Functions

1996 • 864 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

1998 • 858 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ

2001 • 750 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

Reelin and brain development

2003 • 713 citations

Math1 is essential for genesis of cerebellar granule neurons

1997 • 687 citations

Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

2003 • 684 citations

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

2002 • 676 citations

Modes of neuronal migration in the developing cerebral cortex

2002 • 660 citations

Pax6 Controls Radial Glia Differentiation in the Cerebral Cortex

1998 • 647 citations

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

1992 • 638 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Neural plate patterning: Upstream and downstream of the isthmic organizer

2001 • 562 citations

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

1997 • 561 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

2000 • 506 citations

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

2002 • 505 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny

1981 • 497 citations

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

2000 • 482 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon

2001 • 443 citations

T-Brain-1: A homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex

1995 • 415 citations

Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function

1997 • 405 citations

Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

1998 • 404 citations

The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

1999 • 381 citations

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

1998 • 356 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. I. Early ontogeny

1981 • 349 citations

Developmental and Evolutionary Adaptations of Cortical Radial Glia

2003 • 348 citations

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

2003 • 300 citations

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

1996 • 290 citations

Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain

2002 • 286 citations

Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide

2002 • 282 citations

Role of Pax6 in development of the cerebellar system

1999 • 280 citations

The rhombic lip and early cerebellar development

2001 • 275 citations

Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1

1999 • 259 citations

Development of the brain stem in the rat. V. Thymidine‐radiographic study of the time of origin of neurons in the midbrain tegmentum

1981 • 232 citations

EGF Receptor and Notch Signaling Act Upstream of Eyeless/Pax6 to Control Eye Specification

2001 • 232 citations

Pax-6 is involved in the specification of hindbrain motor neuron subtype

1997 • 217 citations

Presenilin-1 regulates neuronal differentiation during neurogenesis

2000 • 216 citations

DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain

1994 • 215 citations

Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

1989 • 214 citations

Expression and Genetic Interaction of Transcription Factors GATA-2 and GATA-3 during Development of the Mouse Central Nervous System

1999 • 211 citations

Development of the Cranial Nerve Ganglia and Related Nuclei in the Rat

1982 • 202 citations

Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus

1993 • 200 citations

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

2002 • 180 citations

Regulation of N-cadherin-mediated adhesion by the p35–Cdk5 kinase

2000 • 177 citations

Neuronal migration

2001 • 168 citations

Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage

2002 • 163 citations

Origin of the Precerebellar System

2000 • 163 citations

Disabled-1-Regulated Adhesion of Migrating Neurons to Radial Glial Fiber Contributes to Neuronal Positioning during Early Corticogenesis

2004 • 162 citations

Nuclear migration, nucleokinesis and lissencephaly

1998 • 161 citations

Coordinating Proliferation and Tissue Specification to Promote Regional Identity in the Drosophila Head

2003 • 155 citations

Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6

1997 • 153 citations

Regulation of the POU domain gene SCIP during cerebral cortical development

1994 • 148 citations

Regional Differences in the Developing Cerebral Cortex Revealed by Ephrin-A5 Expression

1999 • 141 citations

The role of Pax6 in restricting cell migration between developing cortex and basal ganglia

1999 • 138 citations

Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1999 • 136 citations

Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins

1998 • 125 citations

The development of vestibulocochlear efferents and cochlear afferents in mice

1997 • 124 citations

Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch

2002 • 124 citations

F-Spondin Is Required for Accurate Pathfinding of Commissural Axons at the Floor Plate

1999 • 123 citations

Control of the migratory pathway of facial branchiomotor neurones

2000 • 122 citations

Notch signaling and the determination of appendage identity

2000 • 121 citations

Cadherin-6 in the developing mouse brain: Expression along restricted connection systems and synaptic localization suggest a potential role in neuronal circuitry

1998 • 116 citations

The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4

1999 • 107 citations

Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation

2001 • 107 citations

Early specification and autonomous development of cortical fields in the mouse hippocampus

1997 • 106 citations

Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration

2003 • 106 citations

Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling

2002 • 106 citations

Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline

1993 • 101 citations

Presenilin-dependent “γ-Secretase” Processing of Deleted in Colorectal Cancer (DCC)

2003 • 97 citations

Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells

1995 • 96 citations

Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development

2003 • 88 citations

p35/cdk5 binds and phosphorylates β‐catenin and regulates β‐catenin/presenilin‐1 interaction

2001 • 86 citations

The Eph Kinase Ligand AL-1 Is Expressed by Rostral Muscles and Inhibits Outgrowth from Caudal Neurons

1996 • 84 citations

The isthmic neuroepithelium is essential for cerebellar midline fusion

2003 • 79 citations

Ectopic Engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding

2000 • 68 citations

A role for midbrain arcs in nucleogenesis

2002 • 66 citations

A rough guide to a smooth brain

2000 • 64 citations

Moving on to the cargo problem of microtubule-dependent motors in neurons

2000 • 61 citations

Reelin Signaling and Cdk5 in the Control of Neuronal Positioning

2002 • 45 citations

Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain

2001 • 42 citations

Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin‐1‐deficient mice

2002 • 37 citations

Physical and genetic interaction of filamin with presenilin in Drosophila

2000 • 36 citations

Changing Concepts of Cortical Development

2003 • 21 citations

Distribution of Neuregulin-1 (nrg1) and erbB4 Transcripts in Embryonic Chick Hindbrain

1999 • 20 citations

α-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders

2001 • 16 citations

Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with β-amyloid precursor protein messenger RNA localization

1999 • 10 citations