Heavy Chain Diseases: Current Findings and Concepts

Heavy chain disease—A new disorder of serum γ-globulins

1964 • 343 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Alpha-Chain Disease: A New Immunoglobulin Abnormality

1968 • 298 citations

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

1979 • 131 citations

Immunochemical studies in four cases of alpha chain disease

1969 • 129 citations

STUDIES ON ALPHA CHAIN DISEASE*

1971 • 119 citations

Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: Detection of inactive light-chain messenger RNA

1974 • 118 citations

Partial Deletion in the Heavy Chain Disease Protein ZUC

1969 • 113 citations

Heavy Chain Disease of the µ (γM) Type: Report of the First Case

1970 • 106 citations

Five cases of alpha chain disease

1972 • 94 citations

Hinge-regIon deletion localized in the IgG1-globulin Mcg

1973 • 78 citations

Intracytoplasmic and surface-bound immunoglobulins in "nonsecretory" and Bence-Jones myeloma.

1976 • 72 citations

Structural Variants of Human and Murine Immunoglobulins

1975 • 71 citations

The Molecular Defect in a Protein (CRA) Found in γ1 Heavy Chain Disease, and Its Genetic Implications

1971 • 71 citations

Murine heavy chain disease

1978 • 63 citations

Immunodiagnosis of alpha chain disease.

1979 • 63 citations

Light chain typing of immunoglobulins in small samples of biological material.

1970 • 58 citations

Molecular Defect in a Gamma-2 (γ2) Heavy Chain

1972 • 55 citations

Alpha and Gamma Heavy Chain Diseases in Man: Intracellular Origin of the Aberrant Polypeptides

1972 • 51 citations

Alpha-chain disease with involvement of the respiratory tract in a Dutch child.

1971 • 50 citations

Alpha-Chain Disease

1976 • 49 citations

ALPHA-CHAIN DISEASE: EVIDENCE FOR COMMON CLONAL ORIGIN OF INTESTINAL IMMUNOBLASTIC LYMPHOMA AND PLASMACYTIC PROLIFERATION

1977 • 49 citations

Gamma heavy chain disease—An expanding clinical and laboratory spectrum

1973 • 48 citations

Ultrastructural and Immunofluorescence Studies of the Cells Associated With µ-Chain Disease

1971 • 44 citations

“Alpha Chain Disease” Protein Def: Internal Deletion of a Human Immunoglobulin A ₁ Heavy Chain

1974 • 44 citations

The mutual clonal origin of the lymphoplasmocytic and lymphoma cell in alpha-heavy chain disease.

1977 • 37 citations

The amino acid sequence of “heavy chain disease” protein ZUC. Structure of the Fc fragment of immunoglobulin G3

1976 • 37 citations

Alpha-chain Disease with Pulmonary Manifestations

1974 • 36 citations

Immunoglobulin M Heavy Chain Disease: Intracellular Origin of the Mu Chain Fragment

1970 • 35 citations

Protein Hal: Partial Deletion of a “γ” Immunoglobulin Gene(s) and Apparent Reinitiation at an Internal AUG Codon

1973 • 35 citations

An alpha heavy chain abnormality in a child with hypogammaglobulinemia

1973 • 34 citations

Rocket Immunoselection for Detection of Heavy-Chain Diseases

1974 • 30 citations

The defect in mu heavy chain disease protein GLI.

1976 • 29 citations

Multiple myeloma (light chain disease) with rheumatoid-like amyloid arthropathy and μ-heavy chain fragment in the serum

1978 • 26 citations

Celluar immunoglobulins in human gamma- and alpha-heavy chain diseases.

1979 • 26 citations

An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein

1978 • 26 citations

Human heavy chain disease protein WIS: implications for the organization of immunoglobulin genes.

1979 • 25 citations

Deletion of hinge region of human myeloma lgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes. A possible genetic explanation at the DNA level

1976 • 25 citations

Detection in Normal Plasma of Immunoglobulin resembling the Protein of γ-Chain Disease

1973 • 24 citations

A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.

1976 • 23 citations

µ-Chain Disease

1979 • 22 citations

The Defect in µ Heavy Chain Disease Protein GLI

1976 • 21 citations

Split immunoglobulin genes and human heavy chain deletion-mutants.

1979 • 20 citations

N- and C-terminal amino acid sequences of a γ-heavy chain disease protein YOK

1976 • 20 citations

Alpha-chain disease with localized plasmacytoma of the intestine. Immunoperoxidase study.

1976 • 20 citations

Immunochemical and biochemical study of a human Fcμ fragment (μ‐chain disease)

1975 • 19 citations

Gamma heavy chain disease simulating alpha chain disease.

1978 • 19 citations

α–Chain Disease: A Possible Model for the Pathogenesis of Human Lymphomas

1978 • 18 citations

A New Case of Heavy μ-Chain Disease

1975 • 18 citations

Variant of a human immunoglobulin: “Alpha chain disease” protein AIT

1975 • 16 citations

Physicochemical and immunological properties of a μ chain disease protein

1976 • 16 citations

Unusual genes at the aminoterminus of human immunoglobulin variants

1978 • 15 citations

Gamma heavy chain disease in man: translation and partial purification of mRNA coding for the deleted protein.

1978 • 13 citations

Structural characterization of γ1-heavy chain disease protein BAZ: Heterogeneity of the constant region

1977 • 12 citations

The structural heterogeneity among degraded gamma heavy chain disease proteins.

1978 • 12 citations

Correlation of protein structure and immunoglobulin gene organization in the light of two new deleted heavy chain disease proteins

1979 • 12 citations

Gamma heavy chain disease in man: synthesis of a deleted gamma3 immunoglobulin by lymphoid cells in short and long term tissue culture.

1978 • 10 citations

The Structural Heterogeneity among Degraded γ Heavy Chain Disease Proteins

1978 • 9 citations

Monoclonal IgM cryoglobulinemia associated with gamma‐3 heavy chain disease: immunochemical and biochemical studies

1978 • 8 citations

[Gamma heavy chain disease. A recent case with plasmocytic proliferation and cranial lacunae].

1977 • 6 citations

mu-chain disease. Report of two new cases

1979 • 4 citations

Maladie des chaînes lourdes gamma. Une nouvelle observation avec prolifération plasmocytaire et lacunes crâniennes

1977 • 2 citations