Acute and chronic exposure of mouse cerebral microvessel endothelial cells to increased concentrations of glucose and galactose: Effect on myo-inositol metabolism, PGE2 synthesis, and transport activity

The Statistical Analysis of Enzyme Kinetic Data

1967 • 1,068 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Modification of the lowry procedure for the analysis of proteolipid protein

1972 • 563 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.

1983 • 246 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

Nerve Glucose, Fructose, Sorbitol,myo-Inositol, and Fiber Degeneration and Regeneration in Diabetic Neuropathy

1988 • 243 citations

Are Disturbances of Sorbitol, Phosphoinositide, and Na+-K+-ATPase Regulation Involved in Pathogenesis of Diabetic Neuropathy?

1988 • 183 citations

Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity

1984 • 178 citations

Increased Vascular Permeability in Spontaneously Diabetic BB/W Rats and in Rats With Mild Versus Severe Streptozocin-Induced Diabetes: Prevention by Aldose Reductase Inhibitors and Castration

1987 • 156 citations

Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect.

1982 • 146 citations

Prevention and Reversal of Defective Axonal Transport and Motor Nerve Conduction Velocity In Rats with Experimental Diabetes by Treatment with the Aldose Reductase Inhibitor Sorbinil

1984 • 134 citations

Cerebral microvessels and derived cells in tissue culture: Isolation and preliminary characterization

1979 • 133 citations

Role of the Blood‐Brain Barrier in the Formation of Long‐Chain ω‐3 and ω‐6 Fatty Acids from Essential Fatty Acid Precursors

1990 • 113 citations

Cerebral microvessels and derived cells in tissue culture

1981 • 112 citations

Purification of murine endothelial cell cultures by flow cytometry using fluorescein-labeled griffonia simplicifolia agglutinin.

1989 • 105 citations

Prevention of Basement Membrane Thickening in Retinal Capillaries by a Novel Inhibitor of Aldose Reductase, Tolrestat

1986 • 101 citations

Myoinositol Metabolism in Diabetes Mellitus: Effect of Insulin Treatment

1977 • 99 citations

Endothelial cell function in diabetic microangiopathy

1987 • 97 citations

Eicosanoid metabolism in cerebromicrovascular endothelium

1988 • 94 citations

Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?

1988 • 80 citations

Immunohistochemical Staining and Enzyme Activity Measurements Show myo‐Inositol‐1‐Phosphate Synthase to Be Localized in the Vasculature of Brain

1987 • 77 citations

Non-competitive inhibition of myo-inositol transport in cultured bovine retinal capillary pericytes by glucose and reversal by Sorbinil

1986 • 75 citations

Basal phosphatidylinositol turnover controls aortic Na+/K+ ATPase activity.

1986 • 74 citations

Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity

1984 • 65 citations

Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits

1989 • 61 citations

Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound bay g 6575

1980 • 58 citations

Sorbinil Prevents Diabetes-induced Increases in Vascular Permeability But Does Not Alter Collagen Cross-Linking

1985 • 54 citations

Myoinositol uptake by four cultured mammalian cell lines

1986 • 52 citations

myo‐Inositol Metabolism in 41 A3 Neuroblastoma Cells: Effects of High Glucose and Sorbitol Levels

1987 • 50 citations

Increased prostacyclin release from perfused hearts of acutely diabetic rats

1980 • 47 citations

Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Prevention by aldose reductase inhibitors and castration

1987 • 47 citations

Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil

1984 • 46 citations

Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat

1986 • 44 citations

Myoinositol metabolism in diabetes mellitus. Effect of insulin treatment

1977 • 41 citations

Insulin Regulation of Na/K Pump Activity in Rat Hepatoma Cells

1984 • 40 citations

Permeability Changes in Blood-Retinal Barrier of Galactosemic Rats Are Prevented by Aldose Reductase Inhibitors

1987 • 36 citations

Does Galactose Feeding Provide a Valid Model of Consequences of Exaggerated Polyol-Pathway Flux in Peripheral Nerve in Experimental Diabetes?

1987 • 35 citations

Effect of experimentally induced diabetes on swine vascular prostacyclin (PGI2) synthesis.

1980 • 34 citations

Depletion of myo‐Inositol and Amino Acids in Galactosemic Neuropathy

1987 • 33 citations

The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats

1984 • 32 citations

Competitive inhibition by glucose of myo-inositol incorporation into cultured porcine aortic endothelial cells

1990 • 32 citations

Sorbinil prevents diabetes-induced increases in vascular permeability but does not alter collagen cross-linking

1985 • 30 citations

Effect of Galactose and Glucose Levels and Sorbinil Treatment on myo-Inositol Metabolism and Na+-K+ Pump Activity in Cultured Neuroblastoma Cells

1989 • 27 citations

Na+-K+-ATPase Pumping Activity Is Not Directly Linked to myo-inositol Levels After Sorbinil Treatment in Lenses of Diabetic Rats

1987 • 27 citations

Effect of Increased Glucose Levels on Na⁺/K⁺‐Pump Activity in Cultured Neuroblastoma Cells

1988 • 26 citations

Altered aortic and cremaster muscle prostaglandin synthesis in diabetic rats

1985 • 25 citations

Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium

1988 • 25 citations

Effect of Sorbinil on myo‐Inositol Metabolism in Cultured Neuroblastoma Cells Exposed to Increased Glucose Levels

1988 • 25 citations

Myo-inositol transport into endothelial cells derived from nervous system microvessels

1990 • 23 citations

Aldose reductase and retinal capillary basement membrane thickening

1988 • 22 citations

Sorbinil prevents the galactose-induced inhibition of prostaglandin synthesis in lens cells.

1988 • 19 citations

Cerebral cortical capillary basement membrane thickening in galactosaemic rats

1987 • 18 citations

Does galactose feeding provide a valid model of consequences of exaggerated polyol-pathway flux in peripheral nerve in experimental diabetes?

1987 • 17 citations

Insulin regulation of Na/K pump activity in rat hepatoma cells

1984 • 16 citations

Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats

1987 • 15 citations

Permeability changes in blood-retinal barrier of galactosemic rats are prevented by aldose reductase inhibitors

1987 • 13 citations

Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells

1989 • 12 citations

Effect of Rapid Normalization of Plasma Glucose Levels on Microvascular Dysfunction and Polyol Metabolism in Diabetic Rats

1988 • 8 citations

Effect of rapid normalization of plasma glucose levels on microvascular dysfunction and polyol metabolism in diabetic rats

1988 • 6 citations

Effect of streptozotocin-induced diabetes on prostaglandin production by rat cerebral microvessels

1986 • 4 citations

Deleted Work

1955 • 0 citations