Role of the Blood‐Brain Barrier in the Formation of Long‐Chain ω‐3 and ω‐6 Fatty Acids from Essential Fatty Acid Precursors

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol

1964 • 5,892 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

1984 • 1,616 citations

Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function

1985 • 1,344 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

1979 • 786 citations

The Essentiality Of N-3 Fatty Acids For The Development And Function Of The Retina And Brain

1988 • 621 citations

Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Other Derivatives of Carbon‐20 Unsaturated Fatty Acids

1982 • 580 citations

HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization.

1987 • 427 citations

DOCOSAHEXAENOIC ACID: MEMBRANE FUNCTION AND METABOLISM

1986 • 319 citations

Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissues

1987 • 269 citations

Lipid nutrition and metabolism of cultured mammalian cells☆

1980 • 215 citations

Separation and quantitation of free fatty acids and fatty acid methyl esters by reverse phase high pressure liquid chromatography

1983 • 206 citations

Uptake and Transport of Fatty Acids into the Brain and the Role of the Blood–Brain Barrier System

1973 • 181 citations

Utilization of arachidonic and linoleic acids by cultured human endothelial cells.

1981 • 175 citations

Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes

1987 • 164 citations

Fatty acid metabolism of isolated mammalian cells

1987 • 158 citations

Fatty Acid Transport Through the Blood‐Brain Barrier

1988 • 143 citations

Cerebral microvessels and derived cells in tissue culture: Isolation and preliminary characterization

1979 • 133 citations

Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells.

1983 • 133 citations

IN VITRO FORMATION OF POLYUNSATURATED FATTY ACIDS BY DESATURATION IN RAT BRAIN: SOME PROPERTIES OF THE ENZYMES IN DEVELOPING BRAIN AND COMPARISONS WITH LIVER¹

1978 • 121 citations

Cerebral microvessels and derived cells in tissue culture

1981 • 112 citations

Uptake of fatty acids by the developing rat brain

1988 • 107 citations

Purification of murine endothelial cell cultures by flow cytometry using fluorescein-labeled griffonia simplicifolia agglutinin.

1989 • 105 citations

Supply of polyenoic fatty acids to the mammalian brain: The ease of conversion of the short-chain essential fatty acids to their longer chain polyunsaturated metabolites in liver, brain, placenta and blood

1981 • 95 citations

Eicosanoid metabolism in cerebromicrovascular endothelium

1988 • 94 citations

Effect of Polyunsaturated Fatty Acids on Fetal Mouse Brain Cells in Culture in a Chemically Defined Medium

1983 • 94 citations

Cerebrovascular actions of prostaglandins

1982 • 85 citations

Fatty acid uptake by the brain. 3. Incorporation of (1-14C)oleic acid into the adult rat brain.

1970 • 80 citations

Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids

1986 • 79 citations

The incorporation of linolenic acid and docosahexaenoic acid into liver and brain lipids of developing rats

1972 • 78 citations

Essential fatty acids deficiency in humans

1980 • 76 citations

Biosynthesis of polyunsaturated fatty acids in the developing brain: I. Metabolic transformations of intracranially administered 1‐¹⁴C linolenic acid

1976 • 68 citations

Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes

1987 • 65 citations

Inhibitors of fatty acid oxidation

1987 • 60 citations

Accumulation of N‐3 Polyunsaturated Fatty Acids by Cultured Human Y79 Retinoblastoma Cells

1981 • 55 citations

Fatty acyl Δ6 desaturation activity of cultured human endothelial cells modulation by fetal bovine serum

1983 • 52 citations

Characterization of the blood-brain barrier: glycoconjugate receptors of 14 lectins in canine brain, cultured endothelial cells, and blotted membrane proteins

1987 • 51 citations

Incorporation and metabolism of exogenous fatty acids by cultured normal and tumoral glial cells

1983 • 46 citations

Synthesis of chain elongation-desaturation products of linoleic acid by liver and brain microsomes during development of the pig

1985 • 45 citations

Fatty acid uptake by the brain. V. Incorporation of (I- 14 C)linolenic acid into adult rat brain.

1971 • 45 citations

THE IN VIVO INCORPORATION OF LINOLENIC ACID INTO NEURONAL and GLIAL CELLS and MYELIN¹

1978 • 45 citations

Hepatic Metabolism of Dietary Alpha-Linolenic Acid in Suckling Rats, and Its Possible Importance in Polyunsaturated Fatty Acid Uptake by the Brain

1986 • 43 citations

Fatty acid uptake by the brain V. incorporation of [1-14c]linolenic acid into adult rat brain

1971 • 41 citations

Polyenoic acid metabolism in cultured dissociated brain cells

1974 • 36 citations

Fatty acid uptake by the brain IV. Incorporation of [1-14C]linoleic acid into the adult rat brain

1971 • 36 citations

Brain Microvessels Produce 12‐Hydroxyeicosatetraenoic Acid

1989 • 35 citations

Eicosapentaenoic acid metabolism in brain microvessel endothelium: effect on prostaglandin formation.

1989 • 34 citations

The metabolism of (n − 3) and (n − 6) fatty acids and their oxygenation by platelet cyclooxygenase and lipoxygenase

1986 • 30 citations

BIOSYNTHESIS OF LONG CHAIN FATTY ACIDS BY OLIGODENDROGLIA ISOLATED FROM BOVINE WHITE MATTER¹

1975 • 28 citations

Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells

1986 • 26 citations

Unaltered brain membranes after prolonged intake of highly oxidizable long-chain fatty acids of the (n − 3) series

1987 • 23 citations

Selective utilization of ω 6 and ω 3 polyunsaturated fatty acids by human skin fibroblasts

1982 • 20 citations

A comparison of lipid metabolism in two human retinoblastoma cell lines.

1985 • 18 citations