Chronic effects of fluoxetine, a selective inhibitor of serotonin uptake, on neurotransmitter receptors

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1970 • 534 citations

Mode of action of antidepressant drugs

1978 • 514 citations

Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

1976 • 494 citations

A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine

1974 • 461 citations

A possible common mechanism of action of antidepressant treatments

1976 • 410 citations

A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.

1975 • 358 citations

Is there a role for serotonin (5-hydroxytryptamine) in feeding?

1977 • 345 citations

A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.

1985 • 244 citations

On the Slowness of Action of Tricyclic Antidepressant Drugs

1972 • 226 citations

Differential effects of antidepressant treatment on brain monoaminergic receptors

1980 • 222 citations

Amitriptyline, Weight Gain and Carbohydrate Craving: A Side Effect

1973 • 219 citations

α2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment

1981 • 216 citations

Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons

1982 • 188 citations

Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors

1983 • 166 citations

A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder.

1985 • 156 citations

Effects of Lilly 110140, a specific inhibitor of 5-hydroxytryptamine uptake, on food intake and on 5-hydroxytryptophan-induced anorexia. Evidence for serotoninergic inhibition of feeding

1976 • 140 citations

Effect of chronic antidepressant treatment and subsequent withdrawal on [3H]-5-hydroxytryptamine and [3H]-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour

1983 • 126 citations

Modifications of central 5-hydroxytryptamine binding sites in synaptic membranes from rat brain after long-term administration of tricyclic antidepressants

1979 • 119 citations

Acceleration of β-receptor desensitization in combined administration of antidepressants and phenoxybenzamine

1981 • 118 citations

Amitriptyline: Long-term treatment elevates α-adrenergic and muscarinic receptor binding in mouse brain

1980 • 93 citations

The effect of tri-iodothyronine in combination with imipramine on [3H]-cyclic AMP production in slices of rat cerebral cortex

1974 • 92 citations

Effects of chronic administration of antidepressant drugs on aggressive behavior induced by clonidine in mice

1980 • 66 citations

Frontiers in Neuropsychiatric Research

1983 • 65 citations

Chronic treatment with antidepressants: Potentiation of clonidine-induced aggression in mice via noradrenergic mechanism

1981 • 65 citations

Pharmacology of antidepressants in use in the United States.

1982 • 63 citations

Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake.

1975 • 63 citations

Serotonergic mechanism in the control of β-endorphin and acth release in male rats

1982 • 61 citations

Serotoninergic Agonists Increase Plasma Levels of β-Endorphin and β-Lipotropin in Humans*

1984 • 60 citations

Differences among ‘serotonergic’ anorectics in a cross-tolerance paradigm: Do they all act on serotonin systems?

1982 • 58 citations

Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: Effects of Nisoxetine versus fluoxetine

1979 • 55 citations

Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.

1983 • 54 citations

Decrease in [3H]-serotonin binding in rat brain produced by the repeated administration of either monoamine oxidase inhibitors or centrally acting serotonin agonists

1980 • 50 citations

Manipulations of synaptic serotonin: Discrepancy of effects on serotonin S1 and S2 sites

1983 • 47 citations

Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors

1985 • 47 citations

Norepinephrine-stimulated cyclic AMP accumulation in brain slices in vitro after serotonin depletion or chronic administration of selective amine reuptake inhibitors.

1977 • 40 citations

Subsensitivity of serotonin receptors after long-term treatment of rats with fluoxetine.

1981 • 38 citations

Effect of blockade of 5-hydroxytryptamine re-uptake on drug-induced antinociception in the rat

1976 • 25 citations

Serotonergic denervation changes binding characteristics of β-adrenoceptors in rat cortex

1982 • 23 citations

The effect of fluoxetine on morphine analgesia, respiratory depression, and lethality

1982 • 17 citations

Clinical Efficacy of the Newer Antidepressants

1981 • 17 citations

Evidence for serotonergic stimulation of pituitary β-endorphin release: Preferential release from the anterior lobe

1983 • 16 citations

Treatment of affective disorders.

1985 • 14 citations

Effect of methiothepin on imipramine- or mianserin-induced subsensitivity of serotonergic receptors

1982 • 13 citations

Chronic amitriptyline potentiates feeding induced by intrahypothalamic norepinephrine injections

1983 • 10 citations

Involvement of brain histamine in Δ9-tetrahydrocannabinol tolerance and withdrawal

1985 • 9 citations