Atherosclerosis: humoral and cellular factors of inflammation

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Beyond Cholesterol

1989 • 6,533 citations

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events

2002 • 3,483 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

2001 • 1,153 citations

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

2001 • 1,070 citations

A Self-Fulfilling Prophecy

2002 • 1,039 citations

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

1998 • 978 citations

Quantitative assessment of atherosclerotic lesions in mice

1987 • 957 citations

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.

1997 • 855 citations

Detection of activated T lymphocytes in the human atherosclerotic plaque.

1989 • 739 citations

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E.

1995 • 700 citations

Homocysteine Impairs the Nitric Oxide Synthase Pathway

2001 • 663 citations

Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes

2002 • 651 citations

Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis.

1995 • 596 citations

Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.

1994 • 541 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 478 citations

Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?

2002 • 476 citations

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

2000 • 472 citations

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

1991 • 451 citations

Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques.

1992 • 412 citations

Infections Caused by Chlamydia pneumoniae Strain TWAR

1992 • 382 citations

C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice

2004 • 380 citations

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

1997 • 346 citations

Homocysteine theory of arteriosclerosis

1975 • 338 citations

Noninvasive Coronary Vessel Wall and Plaque Imaging With Magnetic Resonance Imaging

2000 • 336 citations

Homocysteine Induces Expression and Secretion of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Human Aortic Endothelial Cells

2001 • 335 citations

Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose

2003 • 313 citations

The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae

1999 • 304 citations

LDL Immunization Induces T-Cell–Dependent Antibody Formation and Protection Against Atherosclerosis

2001 • 297 citations

Plasma Concentration of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Is Elevated in Monkeys With Hyperhomocyst(e)inemia or Hypercholesterolemia

2000 • 290 citations

In Vivo Downregulation of T Helper Cell 1 Immune Responses Reduces Atherogenesis in Apolipoprotein E-Knockout Mice

2001 • 288 citations

Neutrophil function in ischemic heart disease.

1989 • 278 citations

Evidence of Systemic Dissemination ofChlamydia pneumoniaevia Macrophages in the Mouse

1998 • 267 citations

Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation

1996 • 260 citations

Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Limits Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E–Knockout Mice

2002 • 255 citations

The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.

1997 • 254 citations

Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice.

1996 • 249 citations

Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells

1997 • 238 citations

Lymphocytes are important in early atherosclerosis

2001 • 234 citations

Chlamydia pneumoniae Infection of Vascular Smooth Muscle and Endothelial Cells Activates NF-κB and Induces Tissue Factor and PAI-1 Expression

1999 • 230 citations

Dietary Supplementation With Methionine and Homocysteine Promotes Early Atherosclerosis but Not Plaque Rupture in ApoE-Deficient Mice

2001 • 213 citations

Lymphocytes are important in early atherosclerosis

2001 • 196 citations

ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis

2001 • 181 citations

Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice

2004 • 178 citations

Non-invasive characterisation of coronary lesion morphology and composition by multislice CT: first results in comparison with intracoronary ultrasound

2001 • 161 citations

Cellular Oxidation of Low‐Density Lipoprotein byChlamydia pneumoniae

1999 • 155 citations

Expression and Localization of Matrix Metalloproteinase-12 in the Aorta of Cholesterol-Fed Rabbits

1998 • 153 citations

Local Hypomethylation in Atherosclerosis Found in Rabbit ec-sod Gene

1999 • 151 citations

Effect of Matrix Metalloproteinase Inhibition on Progression of Atherosclerosis and Aneurysm in LDL Receptor‐Deficient Mice Overexpressing MMP‐3, MMP‐12, and MMP‐13 and on Restenosis in Rats after Balloon Injury

1999 • 141 citations

Increased Monocyte Adhesion to Aortic Endothelium in Rats With Hyperhomocysteinemia

2002 • 140 citations

Detection of Chlamydia pneumoniae –Reactive T Lymphocytes in Human Atherosclerotic Plaques of Carotid Artery

2000 • 139 citations

Histological and Ultrastructural Features of Atherosclerosis in Progeria

1999 • 138 citations

Antiinflammatory and Antiarteriosclerotic Actions of HMG-CoA Reductase Inhibitors in a Rat Model of Chronic Inhibition of Nitric Oxide Synthesis

2001 • 130 citations

Long-Term Stable Expression of Human Apolipoprotein A-I Mediated by Helper-Dependent Adenovirus Gene Transfer Inhibits Atherosclerosis Progression and Remodels Atherosclerotic Plaques in a Mouse Model of Familial Hypercholesterolemia

2003 • 123 citations

Involvement of chemokine receptor 2 and its ligand, monocyte chemoattractant protein-1, in the development of atherosclerosis: lessons from knockout mice

2001 • 123 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 119 citations

Dietary protein, cholesterol and atherosclerosis: a review of the early history.

1995 • 115 citations

Chlamydia pneumoniae Infection of Human Endothelial Cells Induces Proliferation of Smooth Muscle Cells via an Endothelial Cell-Derived Soluble Factor(s)

1999 • 96 citations

Atherosclerotic Lesions at Micro CT: Feasibility for Analysis of Coronary Artery Wall in Autopsy Specimens

2004 • 78 citations

Watanabe rabbits with heritable hypercholesterolaemia: a model of atherosclerosis.

1998 • 76 citations

Fatality of Future Coronary Events Is Related to Inflammation-Sensitive Plasma Proteins

2004 • 74 citations

Efficacy and safety of Simvastatin 80 mg/day in hypercholesterolemic patients

1998 • 74 citations

Factors involved in the maintenance of endothelial function

1998 • 63 citations

Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet–Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E–Deficient Compared With Wild-Type Mice

2000 • 59 citations

Inhibitory Effect on Arterial Injury-Induced Neointimal Formation by Adoptive B-Cell Transfer in Rag-1 Knockout Mice

2002 • 49 citations

Clinical Articles Low Prevalence of Chlamydia pneumoniae in Atherectomy Specimens from Patients with Coronary Heart Disease

1999 • 48 citations

Plasma asymmetric dimethylarginine and hyperemic myocardial blood flow in young subjects with borderline hypertension or familial hypercholesterolemia

2002 • 48 citations

Lymphocyte responses to Chlamydia antigens in patients with coronary heart disease

1997 • 47 citations

CD143 in the development of atherosclerosis

2000 • 39 citations

Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs.

1994 • 36 citations

No Evidence of Involvement of Chlamydia pneumoniae in Severe Cerebrovascular Atherosclerosis by Means of Quantitative Real-Time Polymerase Chain Reaction

2004 • 31 citations

Factors involved in the maintenance of endothelial function

1998 • 26 citations

High-Resolution Magnetic Resonance Imaging at 2 Tesla: Potential for Atherosclerotic Lesions Exploration in the Apolipoprotein E Knockout Mouse

2003 • 17 citations

Effects of 3-deazaadenosine on homocysteine and atherosclerosis in apolipoprotein E-deficient mice

2003 • 15 citations

Discussion

1999 • 14 citations

MRL/lprand MRL+/+ Macrophage DNA Synthesis in the Absence and the Presence of Colony-Stimulating Factor-1 and Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 11 citations