T Cells Cloned from Human Rheumatoid Synovial Membrane Functionally Represent the Th 1 Subset

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Functional discrimination between interleukin 6 and interleukin 1

1988 • 443 citations

Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

1975 • 387 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis.

1991 • 308 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

Selection of a human T helper type 1-like T cell subset by mycobacteria.

1991 • 281 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis

1988 • 248 citations

Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

1985 • 240 citations

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

1991 • 201 citations

Antigen‐specific cytotoxic T cell and antigen‐specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3

1985 • 175 citations

Measurement of immunoreactive interleukin-1β from human mononuclear cells: Optimization of recovery, intrasubject consistency, and comparison with interleukin-1α and tumor necrosis factor

1988 • 173 citations

Production of lymphokine mRNA by CD45R+ and CD45R- helper T cells from human peripheral blood and by human CD4+ T cell clones.

1989 • 169 citations

Simple, sensitive and specific bioassay of interleukin-1

1989 • 159 citations

Elution and Characterization of Lymphocytes from Rheumatoid Inflammatory Tissue

1975 • 144 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies.

1985 • 126 citations

Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA

1985 • 117 citations

In situ localization of lymphocyte subsets in synovial membranes of patients with rheumatoid arthritis with monoclonal antibodies.

1982 • 110 citations

Clonal analysis of functionally distinct human CD4+ T cell subsets.

1988 • 93 citations

Non‐random expression of T cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood

1989 • 86 citations

DONOR-SPECIFIC LYSIS OF HUMAN KIDNEY PROXIMAL TUBULAR EPITHELIAL CELLS BY RENAL ALLOGRAFT-INFILTRATING LYMPHOCYTES

1989 • 72 citations

Similarity between in vitro and in vivo cellular aging

1983 • 58 citations

Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.

1988 • 53 citations

Efficient Propagation and Cloning of Human T Cells in the Absence of Antigen by Means of OKT3, Interleukin 2, and Antigen‐Presenting Cells

1988 • 49 citations

Elution and Characterization of Lymphocytes from Rheumatoid Inflammatory Tissue

1975 • 49 citations

Phenotypic and functional characterization of human T cell clones.

1988 • 48 citations

Development and application of radioimmunoassays for interleukin-1α and interleukin-1β

1989 • 41 citations

CD4⁺ T‐Cell Clones from Autoimmune Thyroid Tissue Cannot be Classified According to their Lymphokine Production

1990 • 37 citations

Helper interleukins are produced by both CD4 and CD8 splenic T cells after mitogen stimulation

1991 • 31 citations

Expression of Activation Markers on CD4⁺ and CD8⁺ Cells from Synovial Fluid, Synovial Tissue, and Peripheral Blood of Patients with Inflammatory Arthritides

1989 • 29 citations

Interleukin 1: a regulator of chondrocyte proliferation

1989 • 26 citations

An immunohistological study of CD4+ lymphocyte subsets within inflammatory lesions with special reference to rheumatoid arthritis and inflammatory bowel disease.

1988 • 25 citations

Inhibition of T Cell Cytolytic Potential by Concanavalin A: A Result of Activation?

1987 • 7 citations