Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood.

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

Transfer of a functional human immune system to mice with severe combined immunodeficiency

1988 • 1,248 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Human naive and memory T cells

1988 • 793 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

1986 • 515 citations

Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells

1988 • 471 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome.

1989 • 409 citations

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

1988 • 389 citations

Long-term human hematopoiesis in the SCID-hu mouse.

1990 • 353 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Single step separation of human T and B cells using AET treated SRBC rosettes

1976 • 337 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry.

1985 • 261 citations

A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

1991 • 235 citations

THE HUMAN THYMUS CONTAINS A NOVEL POPULATION OF B LYMPHOCYTES

1987 • 223 citations

Prevention of Allogeneic Bone Marrow Graft Rejection by H-2 Transgene in Donor Mice

1989 • 218 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

Tolerance of T-cell clones is associated with membrane antigen changes

1983 • 187 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice.

1989 • 177 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

Interleukin-4 mediates CDS induction on human CD4+ T-cell clones

1988 • 163 citations

Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.

1991 • 130 citations

Unusual phenotype of B cells in the thymus of normal mice.

1988 • 127 citations

Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans.

1991 • 124 citations

T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses.

1984 • 105 citations

Biosynthesis and surface expression of T8 by peripheral blood T4+ cells in vitro.

1986 • 92 citations

Enhanced ELISA: how to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours

1988 • 87 citations

Beta 1 integrin (CD29) expression on human postnatal T cell subsets defined by selective CD45 isoform expression.

1991 • 71 citations

Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy.

1990 • 66 citations

Leu-8 antigen expression is diminished during cell activation but does not correlate with effector function of activated T lymphocytes.

1988 • 63 citations

Molecules and Regulation in Lymphocyte Migration

1989 • 46 citations

Selective expression of CD45 isoforms and of maturation antigens during human thymocyte differentiation: observations and hypothesis

1989 • 46 citations

Characterization of antigen processing and presentation by resting B lymphocytes.

1988 • 45 citations

In situ localization of CD45 isoforms in the human thymus indicates a medullary location for the thymic generative lineage.

1990 • 42 citations

Acute lethal graft-versus-host reaction induced by major histocompatibility complex class II-reactive T helper cell clones.

1990 • 34 citations

I-A alpha polymorphic residues that determine alloreactive T cell recognition.

1989 • 30 citations

Induction of graft versus host-associated immunodeficiency by CD4+ T cell clones.

1990 • 24 citations

Interleukin 2 receptor dysfunction in mice undergoing a graft-vs-host reaction.

1985 • 12 citations

Isolated peripheral T cells from GvHR recipients exhibit defective IL-2R expression, IL-2 production, and proliferation in response to activation stimuli.

1990 • 7 citations

B cells as antigen-presenting cells: Antigen-specific IL-2 production by cloned T cells without expression of IL-2 receptors

1987 • 5 citations

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