Down-regulation of CD3zeta is a breast cancer biomarker associated with immune suppression

Estimation of the Youden Index and its Associated Cutoff Point

2005 • 2,141 citations

Understanding diagnostic tests 3: receiver operating characteristic curves

2007 • 1,698 citations

Optimal Cut-point and Its Corresponding Youden Index to Discriminate Individuals Using Pooled Blood Samples

2004 • 1,059 citations

<scp>l</scp>-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

2003 • 458 citations

The Youden Index and the Optimal Cut‐Point Corrected for Measurement Error

2005 • 246 citations

l-Arginine modulates CD3ζ expression and T cell function in activated human T lymphocytes

2004 • 200 citations

Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma.

1998 • 147 citations

Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays

2008 • 116 citations

Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations

2006 • 115 citations

Helicobacter pylori Arginase Inhibits T Cell Proliferation and Reduces the Expression of the TCR ζ-Chain (CD3ζ)

2004 • 114 citations

Use of High-Throughput Protein Array for Profiling of Differentially Expressed Proteins in Normal and Malignant Breast Tissue

2004 • 101 citations

Antibody arrays—An emerging tool in cancer proteomics

2007 • 78 citations

Human TCR That Incorporate CD3ζ Induce Highly Preferred Pairing between TCRα and β Chains following Gene Transfer

2008 • 77 citations

Loss of heterozygosity on chromosome arm 16q in breast cancer metastases

1997 • 76 citations

Decreased Expression of CD3ζ and Nuclear Transcription Factor κB in Patients with Pulmonary Tuberculosis: Potential Mechanisms and Reversibility with Treatment

2006 • 71 citations

IPO-38 Is Identified as a Novel Serum Biomarker of Gastric Cancer Based on Clinical Proteomics Technology

2008 • 52 citations

Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: Prevalence of alterations in inflammatory breast cancers

2000 • 50 citations

Down-regulation of CD28, TCR-zeta (zeta) and up-regulation of FAS in peripheral cytotoxic T-cells of primary breast cancer patients.

2008 • 44 citations

Decreased Expression of ζ Molecules by T Lymphocytes Is Correlated with Disease Progression in Human Immunodeficiency Virus–Infected Persons

1999 • 38 citations

Loss of T-cell receptor-CD3ζ and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma

2001 • 35 citations

Down-regulation of the CD3-ζ chain in sentinel node biopsies from breast cancer patients

2002 • 33 citations

CD28 expression in sentinel node biopsies from breast cancer patients in comparison with CD3-zeta chain expression.

2004 • 29 citations

Proteomic Analysis of Autocrine/Paracrine Effects of Human Growth Hormone in Human Mammary Carcinoma Cells

2008 • 15 citations

Association between the expression of IL-10 and T cell activation proteins loss in early breast cancer patients

2008 • 10 citations

Immunobiological Characterization of N-Nitrosomethylurea-Induced Rat Breast Carcinomas: Tumoral IL-10 Expression as a Possible Immune Escape Mechanism

2004 • 9 citations

Evaluation of the Predictive Performance of Nutritional Indicators by Receiver‐Operating Characteristic Curve Analysis

1991 • 8 citations

Defective CD3ζ chain expression in Herpesvirus saimiri (HVS)-derived T-cell lines in gastric adenocarcinoma

2005 • 6 citations

Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier

2007 • 5 citations