Genetic analysis of myosin II assembly and organization in model organisms

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination

1987 • 984 citations

A Millennial Myosin Census

2001 • 745 citations

Spatial and Temporal Pathway for Assembly and Constriction of the Contractile Ring in Fission Yeast Cytokinesis

2003 • 413 citations

Involvement of an Actomyosin Contractile Ring in Saccharomyces cerevisiae Cytokinesis

1998 • 408 citations

Sequential Assembly of Myosin II, an IQGAP-like Protein, and Filamentous Actin to a Ring Structure Involved in Budding Yeast Cytokinesis

1998 • 373 citations

Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site.

1991 • 342 citations

Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain

1988 • 326 citations

Differential localization of two myosins within nematode thick filaments

1983 • 303 citations

Spatial Coordination of Cytokinetic Events by Compartmentalization of the Cell Cortex

2004 • 286 citations

Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts

1983 • 286 citations

Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo

1993 • 279 citations

Isolation and Characterization of New Fission Yeast Cytokinesis Mutants

1998 • 270 citations

Regulation of myosin self-assembly: phosphorylation of Dictyostelium heavy chain inhibits formation of thick filaments.

1980 • 252 citations

Role of the Myosin Assembly Protein UNC-45 as a Molecular Chaperone for Myosin

2002 • 245 citations

Roles of Hof1p, Bni1p, Bnr1p, and Myo1p in Cytokinesis inSaccharomyces cerevisiae

2000 • 224 citations

A mutant affecting the heavy chain of myosin in Caenorhabditis elegans

1974 • 221 citations

Type II Myosin Heavy Chain Encoded by the myo2 Gene Composes the Contractile Ring during Cytokinesis in Schizosaccharomyces pombe

1997 • 209 citations

Analysis of mid1p, a Protein Required for Placement of the Cell Division Site, Reveals a Link between the Nucleus and the Cell Surface in Fission Yeast

2000 • 208 citations

The yeast MYO1 gene encoding a myosin-like protein required for cell division.

1987 • 199 citations

The Tem1 small GTPase controls actomyosin and septin dynamics during cytokinesis

2001 • 186 citations

Structure and function of the cytoskeleton of a Dictyostelium myosin-defective mutant.

1990 • 173 citations

Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis.

1995 • 164 citations

Identification of a Second Myosin-II inSchizosaccharomyces pombe:

1997 • 161 citations

Drosophila muscle myosin heavy chain encoded by a single gene in a cluster of muscle mutations

1983 • 161 citations

Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles.

1989 • 156 citations

Functional domains of the Drosophila melanogaster muscle myosin heavy-chain gene are encoded by alternatively spliced exons.

1989 • 155 citations

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body

1998 • 154 citations

On the Role of Myosin-II in Cytokinesis: Division ofDictyosteliumCells under Adhesive and Nonadhesive Conditions

1997 • 151 citations

Chaperone-mediated folding and assembly of myosin in striated muscle

2004 • 146 citations

Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegans

1974 • 138 citations

Paramyosin gene (unc-15) of Caenorhabditis elegans

1989 • 133 citations

UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II

2004 • 130 citations

Immunological identification of the genes encoding the four myosin heavy chain isoforms of Caenorhabditis elegans.

1986 • 124 citations

Immunochemical localization of myosin heavy chain isoforms and paramyosin in developmentally and structurally diverse muscle cell types of the nematode Caenorhabditis elegans.

1987 • 123 citations

Myosin-II reorganization during mitosis is controlled temporally by its dephosphorylation and spatially by Mid1 in fission yeast

2004 • 120 citations

Evidence for F-actin-dependent and -independent mechanisms involved in assembly and stability of the medial actomyosin ring in fission yeast

1999 • 117 citations

Myosin II dynamics and cortical flow during contractile ring formation in Dictyostelium cells

2001 • 115 citations

Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed.

1990 • 115 citations

The minor myosin heavy chain, mhcA, of Caenorhabditis elegans is necessary for the initiation of thick filament assembly.

1989 • 114 citations

Myosin and paramyosin are organized about a newly identified core structure.

1985 • 112 citations

Paramyosin in invertebrate muscles. II. Content in relation to structure and function.

1976 • 111 citations

Proper expression of myosin genes in transgenic nematodes.

1989 • 111 citations

Flightin, a novel myofibrillar protein of Drosophila stretch-activated muscles.

1993 • 109 citations

Molecular and ultrastructural defects in a Drosophila myosin heavy chain mutant: differential effects on muscle function produced by similar thick filament abnormalities.

1988 • 107 citations

Myosin II Folding Is Mediated by a Molecular Chaperonin

1999 • 106 citations

Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe

2000 • 106 citations

Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles

2000 • 104 citations

Mutants affecting paramyosin in Caenorhabditis elegans

1977 • 103 citations

C-Terminal Anchoring of mid1p to Membranes Stabilizes Cytokinetic Ring Position in Early Mitosis in Fission Yeast

2004 • 100 citations

Myosin II localization during cytokinesis occurs by a mechanism that does not require its motor domain

1998 • 99 citations

Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function

2000 • 98 citations

The S. pombe rlc1 gene encodes a putative myosin regulatory light chain that binds the type II myosins myo3p and myo2p

2000 • 97 citations

The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression.

1990 • 88 citations

Paramyosin is necessary for determination of nematode thick filament length in vivo

1980 • 85 citations

Phosphorylation of theDictyostelium myosin II heavy chain is necessary for maintaining cellular polarity and suppressing turning during chemotaxis

1998 • 84 citations

Direct Evidence for a Critical Role of Myosin II in Budding Yeast Cytokinesis and the Evolvability of New Cytokinetic Mechanisms in the Absence of Myosin II

2003 • 84 citations

Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium

2001 • 82 citations

The UCS family of myosin chaperones

2002 • 80 citations

Myosins exist as homodimers of heavy chains: Demonstration with specific antibody purified by nematode mutant myosin affinity chromatography

1978 • 80 citations

Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly

1990 • 80 citations

Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis

2000 • 79 citations

Two homogeneous myosins in body-wall muscle of Caenorhabditis elegans

1977 • 74 citations

Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function.

1986 • 73 citations

Caenorhabditis elegans Unc-45 Is a Component of Muscle Thick Filaments and Colocalizes with Myosin Heavy Chain B, but Not Myosin Heavy Chain a

2000 • 72 citations

Assembly of thick filaments and myofibrils occurs in the absence of the myosin head

1999 • 72 citations

Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly.

1988 • 72 citations

Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development.

1996 • 72 citations

Genetic and morphological evidence for two parallel pathways of cell-cycle-coupled cytokinesis inDictyostelium

2002 • 71 citations

Tails of unconventional myosins

1999 • 67 citations

Spatially and temporally regulated expression of myosin heavy chain alternative exons during Drosophila embryogenesis

2001 • 67 citations

Folding of the Striated Muscle Myosin Motor Domain

2002 • 66 citations

Defects in theDrosophilaMyosin Rod Permit Sarcomere Assembly but Cause Flight Muscle Degeneration

1995 • 63 citations

Myofilin, a protein in the thick filaments of insect muscle

2005 • 58 citations

INDIRECT SUPPRESSION IN CAENORHABDITIS ELEGANS

1978 • 57 citations

Signaling pathways regulating Dictyostelium myosin II.

2002 • 57 citations

Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration.

2002 • 56 citations

Flightin is a Myosin Rod Binding Protein

2003 • 55 citations

Myosin II-Independent Cytokinesis in Dictyostelium. Its Mechanism and Implications.

2000 • 53 citations

Immunocytochemical localization of two myosins within the same muscle cells in caenorhabditis elegans

1978 • 53 citations

Importance of a Myosin II-Containing Progenitor for Actomyosin Ring Assembly in Fission Yeast

2002 • 52 citations

The alteration of myosin isoform compartmentation in specific mutants of Caenorhabditis elegans.

1986 • 51 citations

Genetic interactions between Hsp90 and the Cdc2 mitotic machineryin the fission yeast Schizosaccharomyces pombe

1999 • 50 citations

Molecular genetic truncation analysis of filament assembly and phosphorylation domains of Dictyostelium myosin heavy chain

1994 • 49 citations

Thick filament substructures in Caenorhabditis elegans: evidence for two populations of paramyosin.

1993 • 49 citations

During Multicellular Migration, Myosin II Serves a Structural Role Independent of its Motor Function

2001 • 49 citations

Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: rescue of mutant phenotypes and analysis of defects caused by overexpression.

1994 • 49 citations

Analysis of the Paramyosin/Miniparamyosin Gene

1995 • 44 citations

Hsp90 Protein in Fission Yeast Swo1p and UCS Protein Rng3p Facilitate Myosin II Assembly and Function

2005 • 44 citations

Hydrophobicity variations along the surface of the coiled-coil rod may mediate striated muscle myosin assembly in Caenorhabditis elegans.

1996 • 40 citations

Drosophila paramyosin/miniparamyosin gene products show a large diversity in quantity, localization, and isoform pattern: a possible role in muscle maturation and function.

1996 • 40 citations

Expression in Escherichia coli of a functional Dictyostelium myosin tail fragment.

1987 • 37 citations

Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod

2004 • 35 citations

Role of the two type II myosins, Myo2 and Myp2, in cytokinetic actomyosin ring formation and function in fission yeast

2003 • 34 citations

Myosin rod protein: a novel thick filament component of Drosophila muscle

1997 • 33 citations

Novel Myosin Heavy Chain Kinase Involved in Disassembly of Myosin II Filaments and Efficient Cleavage in MitoticDictyosteliumCells

2002 • 32 citations

Tissue-specific expression of the alternately processed Drosophila myosin heavy-chain messenger RNAs

1989 • 31 citations

Biochemical characterization of a Dictyostelium myosin II heavy‐chain phosphatase that promotes filament assembly

1999 • 27 citations

Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation

2003 • 26 citations

Myosin heavy chain kinase B participates in the regulation of myosin assembly into the cytoskeleton

2002 • 25 citations

Actin Activation of Myosin Heavy Chain Kinase A in Dictyostelium

2004 • 24 citations

Myosin heavy chain gene amplification as a suppressor mutation in Caenorhabditis elegans

1989 • 24 citations

β-Filagenin, a Newly Identified Protein Coassembling with Myosin and Paramyosin in Caenorhabditis elegans

1998 • 22 citations

Cysteine mutants of light chain-2 form disulfide bonds in skeletal muscle myosin.

1993 • 18 citations

Differential Requirement for the Nonhelical Tailpiece and the C Terminus of the Myosin Rod inCaenorhabditis elegansMuscle

2003 • 14 citations

The pathway of myofibrillogenesis determines the interrelationship between myosin and paramyosin synthesis inCaenorhabditis elegans

2003 • 7 citations