Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle

1963 • 1,452 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Genetic studies of the lac repressor

1977 • 610 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

1986 • 538 citations

Detection of Single Base Substitutions by Ribonuclease Cleavage at Mismatches in RNA:DNA Duplexes

1985 • 538 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Myosin Structure and Function in Cell Motility

1987 • 479 citations

Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle

1982 • 464 citations

Muscle Contraction and Free Energy Transduction in Biological Systems

1985 • 446 citations

The Mechanism of Muscle Contractio

1986 • 424 citations

Structure of the actin–myosin interface

1981 • 349 citations

Differential localization of two myosins within nematode thick filaments

1983 • 303 citations

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

1986 • 285 citations

MYOSIN

1984 • 282 citations

Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP.

1988 • 263 citations

Mapping of actin-binding sites on the heavy chain of myosin subfragment 1

1983 • 248 citations

Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.

1983 • 230 citations

ULTRASTRUCTURAL ORGANIZATION OF OBLIQUELY STRIATED MUSCLE FIBERS IN ASCARIS LUMBRICOIDES

1965 • 211 citations

Comprehensive Virology

1979 • 202 citations

Relationship Among Guanine Nucleotide Exchange, GTP Hydrolysis, and Transforming Potential of Mutated ras Proteins

1988 • 196 citations

Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles.

1989 • 156 citations

Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.

1988 • 137 citations

Sequence analysis of mutations that affect the synthesis, assembly and enzymatic activity of the unc-54 myosin heavy chain of Caenorhabditis elegans

1985 • 129 citations

Identification of the structural gene for a myosin heavy-chain in Caenorhabditis elegans

1977 • 114 citations

Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli

1988 • 114 citations

Myosin and paramyosin are organized about a newly identified core structure.

1985 • 112 citations

Mutations in the unc-54 myosin heavy chain gene of caenorhabditis elegans that alter contractility but not muscle structure

1982 • 110 citations

Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family

1989 • 109 citations

Molecular and ultrastructural defects in a Drosophila myosin heavy chain mutant: differential effects on muscle function produced by similar thick filament abnormalities.

1988 • 107 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

A Genetic Method for Determining the Order of Events in a Biological Pathway

1973 • 103 citations

Mutants affecting paramyosin in Caenorhabditis elegans

1977 • 103 citations

Biochemical properties of the ras-related YPT protein in yeast: a mutational analysis.

1987 • 92 citations

Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity

1988 • 92 citations

An actin-binding site on the 20K fragment of myosin subfragment 1

1982 • 83 citations

Myosins exist as homodimers of heavy chains: Demonstration with specific antibody purified by nematode mutant myosin affinity chromatography

1978 • 80 citations

Regulation of non‐muscle myosin structure and function

1987 • 76 citations

Paramyosin of Caenorhabditis elegans

1974 • 74 citations

Assembly Processes in Vertebrate Skeletal Thick Filament Formation

1988 • 74 citations

Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly.

1988 • 72 citations

Directed mutations of the strongly conserved lysine 155 in the catalytic nucleotide-binding domain of beta-subunit of F1-ATPase from Escherichia coli.

1988 • 71 citations

The defective proton-ATPase of uncD mutants of Escherichia coli. Identification by DNA sequencing of residues in the beta-subunit which are essential for catalysis or normal assembly.

1987 • 71 citations

Structure-function relationships in the GTP binding domain of EF-Tu: mutation of Val20, the residue homologous to position 12 in p21.

1988 • 66 citations

Mutations affecting the indirect flight muscles of Drosophila melanogaster

1982 • 64 citations

Directed mutagenesis of the strongly conserved lysine 175 in the proposed nucleotide-binding domain of alpha-subunit from Escherichia coli F1-ATPase.

1988 • 58 citations

Reactive lysyl of myosin subfragment 1: location on the 27K fragment and labeling properties

1981 • 57 citations

The defective proton-ATPase of uncA mutants of Escherichia coli. Identification by DNA sequencing of residues in the alpha-subunit which are essential for catalysis or normal assembly.

1987 • 57 citations

Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster.

1988 • 56 citations

Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis.

1987 • 54 citations

Genetic Control of Complex Bacteriophage Assembly

1979 • 47 citations

Monoclonal antibodies binding to the tail of Dictyostelium discoideum myosin: their effects on antiparallel and parallel assembly and actin-activated ATPase activity.

1986 • 45 citations

Monoclonal antibodies against seven sites on the head and tail of Dictyostelium myosin.

1985 • 45 citations

Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail.

1984 • 38 citations

A short hydrophobic segment next to tryptophan-130 in myosin heavy chain is close to the ribose ring of ADP bound in the adenosinetriphosphatase site

1987 • 28 citations

E. coli F₁ ‐ATPase: Site‐directed mutagenesis of the β‐subunit

1988 • 28 citations

Genetic and biochemical analysis of the eukaryotic flagellum.

1982 • 24 citations

MOLECULAR GENETICS OF NEMATODE MUSCLE

1989 • 22 citations

Control of filament length by the regulatory light chains in skeletal and cardiac myosins.

1987 • 18 citations

The reconstruction of myosin filaments in rabbit psoas muscle from solubilized myosin

1986 • 16 citations

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