The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide

Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable Pathogenesis

1976 • 513 citations

Isoniazid-Associated Hepatitis in 114 Patients

1975 • 372 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

Isoniazid-Associated Hepatitis

1972 • 239 citations

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

1976 • 228 citations

Pharmacokinetics of isoniazid metabolism in man

1976 • 183 citations

Isoniazid Hepatitis

1973 • 162 citations

Short-course chemotherapy for pulmonary tuberculosis.

1975 • 132 citations

ACONCURRENT COMPARISON OF INTERMITTENT (TWICE-WEEKLY) ISONIAZID PLUS STREPTOMYCIN AND DAILY ISONIAZID PLUS PAS IN THE DOMICILIARY TREATMENT OF PULMONARY TUBERCULOSIS; TUBERCULOSIS CHEMOTHERAPY CENTRE, MADRAS.

1964 • 95 citations

The competing risks of tuberculosis and hepatitis for adult tuberculin reactors.

1975 • 92 citations

A concurrent comparison of home and sanatorium treatment of pulmonary tuberculosis in South India

1959 • 88 citations

Comparative trial of isoniazid in combination with thiacetazone or a substituted diphenylthiourea (SU1906) or PAS in the treatment of acute pulmonary tuberculosis in east africans

1960 • 85 citations

Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapy

1971 • 77 citations

Pyrazinamide-isoniazid in tuberculosis.

1954 • 76 citations

Effect of Rifampicin and Isoniazid on Liver Function

1972 • 74 citations

Short-course chemotherapy in pulmonary tuberculosis

1977 • 72 citations

Long-term chemotherapy in the treatment of chronic pulmonary tuberculosis with cavitation

1962 • 64 citations

Co-operative controlled trial of a standard regimen of streptomycin,pas and isoniazid and three alternative regimens of chemotherapy in Britain A report from the British Medical Research Council

1973 • 62 citations

SHORT-COURSE CHEMOTHERAPY IN PULMONARY TUBERCULOSIS

1976 • 61 citations

Isoniazid with thiacetazone in the treatment of pulmonary tuberculosis in East Africa—Second investigationCo-operative Studies in East African Hospitals and Laboratòries with the Collaboration of the East African and British Medical Research Councils

1963 • 57 citations

A controlled comparison of a twice-weekly and three once-weekly regimens in the initial treatment of pulmonary tuberculosis.

1970 • 55 citations

An international co-operative investigation into thiacetazone (thioacetazone) side-effects

1966 • 51 citations

Various Combinations of Isoniazid with Streptomycin or with P.A.S. in the Treatment of Pulmonary Tuberculosis: Seventh Report to the Medical Research Council

1955 • 50 citations

Hepatitis cases in isoniazid treated groups and in a control group.

1976 • 49 citations

CONTROLLED CLINICAL TRIAL OF FOUR SHORT-COURSE (6-MONTH) REGIMENS OF CHEMOTHERAPY FOR TREATMENT OF PULMONARY TUBERCULOSIS

1974 • 49 citations

THE PREVENTION AND TREATMENT OF ISONIAZID TOXICITY IN THE THERAPY OF PULMONARY TUBERCULOSIS. 2. AN ASSESSMENT OF THE PROPHYLACTIC EFFECT OF PYRIDOXINE IN LOW DOSAGE.

1963 • 45 citations

A controlled clinical trial of daily and intermittent regimens of rifampicin plus ethambutol in the retreatment of patients with pulmonary tuberculosis in Hong Kong A Hong Kong tuberculosis treatment services/Brompton hospital/British medical research council investigation

1974 • 44 citations

Isoniazid with thiacetazone (Thioacetazone) in the treatment of pulmonary tuberculosis in East Africa—third investigation: The effect of an initial streptomycin supplement

1966 • 42 citations

The Modern Management and Therapy of Pulmonary Tuberculosis

1977 • 40 citations

Isoniazid with thiacetazone (thioacetazone) in the treatment of pulmonary tuberculosis in East Africa—Fourth investigation: The effect of increasing the dosage of isoniazid†

1966 • 36 citations

Adverse reactions to short-course regimens containing streptomycin, isoniazid, pyrazinamide and rifampicin in Hong Kong

1976 • 36 citations

Acetylator phenotyping of tuberculosis patients using matrix isoniazid or sulphadimidine and its prognostic significance for treatment with several intermittent isoniazid‐containing regimens.

1977 • 35 citations

Isoniazid with thiacetazone (thioacetazone) in the treatment of pulmonary tuberculosis in East Africa-fifth investigation☆

1970 • 34 citations

Acetylation of hydrazine and the formation of 1,2-diacetylhydrazine in vivo.

1959 • 32 citations

Abstracts of the Arris and Gale Lectures on the Anatomy and Pathology of the Rarer Forms of Hernia: Delivered before the Royal College of Surgeons of England

1900 • 30 citations

Isoniazid in Combination with Streptomycin or with P.A.S. in the Treatment of Pulmonary Tuberculosis: A Medical Researh Council Investigation

1953 • 28 citations

A controlled comparison of four regimens of streptomycin plus pyrazinamide in the retreatment of pulmonary tuberculosis

1969 • 28 citations

Isoniazid in the treatment of pulmonary tuberculosis

1952 • 28 citations

Guidelines for the investigation and management of tuberculosis contacts.

1976 • 27 citations

Serum enzyme changes in patients receiving antituberculosis therapy with rifampicin or p-aminosalicylic acid, plus isoniazid and streptomycin

1974 • 23 citations

"DYSPHAGIA ASSOCIATED WITH ANAEMIA."

1928 • 23 citations

A controlled comparison of streptomycin plus pyrazinamide and streptomycin plus pas in the retreatment of patients excreting isoniazid-resistant organisms

1964 • 22 citations

Controlled Comparison of Oral Twice-weekly and Oral Daily Isoniazid plus PAS in Newly Diagnosed Pulmonary Tuberculosis

1973 • 21 citations

Preventive therapy of tuberculous infection.

1974 • 21 citations

[Jaundice during treatment with rifampicin (12 cases)].

1969 • 20 citations

Isoniazid-Associated Hepatitis

1975 • 19 citations

Toxicity of pyrazinamide, administered once weekly in high dosage, in tuberculous patients.

1968 • 19 citations

Isoniazid in Treatment of Pulmonary Tuberculosis: A Medical Research Council Investigation

1953 • 18 citations

A controlled clinical trial of the role of thiacetazone-containing regimens in the treatment of pulmonary tuberculosis in Singapore: Second report

1974 • 17 citations

A comparative study of daily followed by twice or once weekly regimens of ethambutol and rifampicin in retreatment of patients with pulmonary tuberculosis The results at l year

1975 • 16 citations

A controlled clinical trial of the role of thiacetazone-containing regimens in the treatment of pulmonary tuberculosis in Singapore

1971 • 16 citations

A slow-release preparation of isoniazid: pharmacological aspects.

1976 • 15 citations

A slow-release preparation of isoniazid: pharmacological aspects.

1976 • 14 citations

The use of pyrazinamide plus isoniazid in the treatment of pulmonary tuberculosis

1959 • 12 citations

A slow-release preparation of isoniazid: therapeutic efficacy and adverse side-effects.

1976 • 11 citations

Pyrazinamide-isoniazid: comparison with isoniazid-para-aminosalicylic acid in active pulmonary tuberculosis with the choice of regimens determined by chance.

1956 • 11 citations

A second international co-operative investigation into thioacetazone side-effects. 1. The influence of a vitamin and antihistamine supplement.

1970 • 11 citations

Independent Medical Service

1965 • 10 citations

[Comparative study of the treatment of pulmonary tuberculosis by a combination of rifampicin and isoniazid administered daily and twice weekly for a year].

1971 • 9 citations

Study of adverse reactions to a once-weekly regimen of streptomycin plus a slow-release preparation of isoniazid in high dosage for six months

1976 • 7 citations

Initial treatment of tuberculosis with streptomycin and isoniazid combined with either aminosalyl or rifampicin.

1973 • 6 citations

A study of two twice-weekly and a once-weekly continuation regimen of tuberculosis chemotherapy, including a comparison of two durations of treatment

1976 • 6 citations

Streptomycin plus PAS plus pyrazinamide in the retreatment of pulmonary tuberculosis in East Africa: Second report

1973 • 5 citations

The Modern Management and Therapy of Pulmonary Tuberculosis

1977 • 4 citations

A constant-rate infusion apparatus

1959 • 2 citations