Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2006 • 5,824 citations

[12] Assays of glutathione peroxidase

1984 • 4,695 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

2003 • 722 citations

Mitochondrial Dysfunction in Atherosclerosis

2007 • 708 citations

A Role for 12-lipoxygenase in Nerve Cell Death Caused by Glutathione Depletion

1997 • 495 citations

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

2004 • 475 citations

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.

1996 • 369 citations

Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

2005 • 326 citations

Apoptosis-inducing factor: vital and lethal

2006 • 316 citations

A CamKIIα iCre BAC allows brain‐specific gene inactivation

2001 • 287 citations

Glutathione synthesis is essential for mouse development but not for cell growth in culture

2000 • 277 citations

The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability

2005 • 254 citations

Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages

1996 • 249 citations

Baicalein and 12/15-Lipoxygenase in the Ischemic Brain

2006 • 231 citations

The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the Specificity of the Oxygenation Products

1996 • 189 citations

Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

1997 • 178 citations

Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins

1990 • 171 citations

Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase

1998 • 168 citations

12/15-Lipoxygenase, Oxidative Modification of LDL and Atherogenesis

2001 • 126 citations

Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches

2006 • 118 citations

Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes

1994 • 115 citations

Versatility of Selenium Catalysis in PHGPx Unraveled by LC/ESI-MS/MS

2003 • 103 citations

Comparison of the Tamoxifen Regulated Chimeric Cre Recombinases MerCreMer and CreMer

1999 • 89 citations

Testis-Specific Expression of the Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)

2003 • 70 citations

Melatonin is protective in necrotic but not in caspasedependent, free radical‐independent apoptotic neuronal cell death in primary neuronal cultures

2000 • 57 citations

Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism

2000 • 50 citations

Depletion of phospholipid hydroperoxide glutathione peroxidase up‐regulates arachidonate metabolism by 12(S)‐lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells

2003 • 41 citations

Optimized Vector for Conditional Gene Targeting in Mouse Embryonic Stem Cells

2003 • 24 citations