Clonal expansion of myelin basic protein‐reactive T cells in patients with multiple sclerosis: Restricted T cell receptor V gene rearrangements and CDR3 sequence

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

1989 • 711 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Multiple Sclerosis

1982 • 415 citations

Measles Encephalomyelitis — Clinical and Immunologic Studies

1984 • 404 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

1984 • 380 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Experimental Allergic Encephalomyelitis and Autoimmune Disease

1966 • 282 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity

1979 • 251 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.

1985 • 225 citations

Limiting dilution analysis of the cells of immune system I. The clonal basis of the immune response

1984 • 203 citations

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

1991 • 193 citations

Myelin Basic Protein as an Encephalitogen in Encephalomyelitis and Polyneuritis Following Rabies Vaccination

1987 • 175 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity

1992 • 149 citations

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 • 147 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

Activated suppressor cell dysfunction in progressive multiple sclerosis.

1986 • 103 citations

Human disease: Mechanisms in multiple sclerosis

1985 • 100 citations

Neuroimmunology I: Immunoregulation in neurological disease

1982 • 99 citations

Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis.

1993 • 68 citations

Autoreactive T Cells in Multiple Sclerosis

1992 • 48 citations

Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients

1990 • 34 citations

T-cell vaccination in autoimmune diseases from laboratory to clinic

1993 • 12 citations

Degrees of salary and satisfaction

1988 • 11 citations