Examination of an active‐site electrostatic node in the cAMP‐dependent protein kinase catalytic subunit

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A new force field for molecular mechanical simulation of nucleic acids and proteins

1984 • 4,553 citations

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Calculation of electrostatic potentials in an enzyme active site

1987 • 449 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit

1982 • 380 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

1986 • 275 citations

Experiments in physical chemistry

1951 • 248 citations

Expression of the Catalytic Subunit of cAMP-Dependent Protein Kinase in Escherichia coli

1989 • 194 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

RAD25 is a DMA helicase required for DNA repair and RNA polymerase II transcription

1994 • 191 citations

Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase.

1983 • 183 citations

The phosphorylation of proteins: a major mechanism for biological regulation

1985 • 151 citations

Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments

1992 • 142 citations

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

1992 • 122 citations

Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states

1993 • 103 citations

Pre-Steady-State Kinetic Analysis of cAMP-Dependent Protein Kinase Using Rapid Quench Flow Techniques

1996 • 98 citations

Long-Range Surface Charge-Charge Interactions in Proteins

1993 • 83 citations

Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies

1987 • 76 citations

ON THE MECHANISM OF ACTION OF ADRENOCORTICOTROPIC HORMONE: THE BINDING OF CYCLIC-3′,5′-ADENOSINE MONOPHOSPHATE TO AN ADRENAL CORTICAL PROTEIN

1969 • 72 citations

Divalent metal ions influence catalysis and active‐site accessibility in the camp‐dependent protein kinase

1993 • 64 citations

Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase

1988 • 63 citations

Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.

1993 • 47 citations

Isotope partitioning in the adenosine 3',5'-monophosphate dependent protein kinase reaction indicates a steady-state random kinetic mechanism

1988 • 46 citations

cAMP-dependent Protein Kinase: A Framework for a Diverse Family of Enzymes

1988 • 31 citations