Glioblastoma multiforme: Pathology, natural history and treatment

— Tumors of the Central Nervous System

2013 • 1,787 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Assumptions in the radiotherapy of glioblastoma

1980 • 987 citations

An analysis of dose-effect relationship in the radiotherapy of malignant gliomas

1979 • 850 citations

Immunologically Privileged Sites

1978 • 815 citations

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: A prospective multicenter trial of the scandinavian glioblastoma study group

1981 • 417 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Antitumor effects of interferon

1978 • 346 citations

Radiation and High-Dose Metronidazole in Supratentorial Glioblastomas

1976 • 309 citations

Quantitative aspects of reversible osmotic opening of the blood-brain barrier

1980 • 276 citations

High dose radiation therapy in the treatment of malignant gliomas: Final Report

1979 • 273 citations

Radiation therapy of brain tumors

1977 • 249 citations

Intracranial tumors: response and resistance to therapeutic endeavors, 1970–1980

1982 • 235 citations

Immunobiology of primary intracranial tumors

1977 • 210 citations

Hypoxic Sensitizers — Implications for Radiation Therapy

1979 • 209 citations

Human central nervous system distribution of cis-diamminedichloroplatinum and use as a radiosensitizer in malignant brain tumors.

1982 • 195 citations

Serological analysis of cell surface antigens of malignant human brain tumors

1978 • 191 citations

Tumors of the Central Nervous System.

1973 • 185 citations

Glioblastoma Multiforme: A Clinical Survey

1960 • 181 citations

A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery: Final report of an RTOG study

1986 • 174 citations

Heterogeneous chemosensitivities of subpopulations of human glioma cells in culture.

1982 • 170 citations

Meningeal gliomatosis: A review of 12 cases

1980 • 165 citations

Tumors of the Central Nervous System

1953 • 157 citations

TREATMENT OF CEREBRAL METASTASES FROM BREAST CARCINOMA WITH PREDNISOLONE

1957 • 149 citations

Fast neutrons compared with megavoltage X-rays in the treatment of patients with supratentorial glioblastoma: A controlled pilot study

1980 • 140 citations

Histologic factors of prognostic significance in the glioblastoma multiforme

1980 • 136 citations

DETECTION OF BACTERIURIA.

1964 • 132 citations

The Use of Steroids for Control of Cerebral Edema

1964 • 125 citations

Malignant astrocytoma. Hyperfractionated and standard radiotherapy with chemotherapy in a randomized prospective clinical trial

1982 • 122 citations

National Cancer Institute study: evaluation of computed tomography in the diagnosis of intracranial neoplasms. IV. Meningiomas.

1980 • 122 citations

Glioblastoma Multiforme: A Controlled Trial to Assess the Value of Specific Active Immunotherapy in Patients Treated by Radical Surgery and Radiotherapy

1973 • 119 citations

Permanent and removable implants for the brachytherapy of brain tumors

1981 • 111 citations

Hyperthermia for Brain Tumors

1981 • 109 citations

Is the Brain "An Immunologically Privileged Site"?

1964 • 109 citations

The combined effect of hydroxyurea and x-rays on Chinese hamster cells in vitro.

1968 • 109 citations

Cortisone and ACTH as an Adjunct to the Surgery of Craniopharyngiomas

1952 • 109 citations

"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.

1977 • 107 citations

Monitoring of Methotrexate Delivery in Patients with Malignant Brain Tumors After Osmotic Blood-Brain Barrier Disruption

1981 • 104 citations

Extensive necrosis of spontaneous canine mammary adenocarcinoma after extracorporeal perfusion over Staphylococcus aureus Cowans I. I. Description of acute tumoricidal response: morphologic, histologic, immunohistochemical, immunologic, and serologic findings.

1980 • 102 citations

High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme

1981 • 102 citations

Controlled study of CCNU and radiation therapy in malignant astrocytoma

1976 • 88 citations

Stimulatory effects of vitamin A analogs on induction of cell-mediated cytotoxicity in vivo.

1979 • 86 citations

Radiosensitization of Malignant Brain Tumours with Bromouridine (Thymidine Analogue)

1969 • 85 citations

Evaluation of CCNU, VM-26 plus CCNU, and procarbazine in supratentorial brain gliomas

1981 • 85 citations

Super fractionation in glioblastoma multiforme-results of a phase II study

1982 • 82 citations

Fractionation study in the treatment of glioblastoma multiforme

1976 • 81 citations

Nuclear Inclusions in Malignant Gliomas

1965 • 75 citations

Medical Radiation Physics.

1969 • 74 citations

Hyperbaric oxygen and radiation therapy in the management of glioblastoma.

1977 • 74 citations

Dose dependency of Decadron in patients with partially excised brain tumors

1973 • 72 citations

Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.

1970 • 71 citations

Suggestive evidence for in vivo binding of specific antitumor antibodies of human melanomas.

1975 • 69 citations

National Cancer Institute study: evaluation of computed tomography in the diagnosis of intracranial neoplasms. I. Overall results.

1980 • 68 citations

ANTIBODY-DEPENDENT, CELL-MEDIATED CYTOTOXICITY AGAINST MELANOMA CELLS INDUCED BY PLASMAPHERESIS

1976 • 68 citations

Response of cultured human brain tumors to nitrosoureas: Correlation with clinical data

1981 • 66 citations

Tumor Autograft Responses in Patients with Glioblastoma Multiforme

1961 • 65 citations

Evidence for Cancer-specific Antigens in Man

2015 • 64 citations

Osmotic blood-brain barrier disruption: pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors.

1981 • 64 citations

Anti-ATLA (Antibody to the Adult T-Cell Leukemia Cell-Associated Antigen)-Positive Hematologic Malignancies in the Kanto District

1982 • 63 citations

Effect of human leukocyte interferon on malignant brain tumors

1983 • 61 citations

Medical Radiation Physics

1969 • 61 citations

Current status of clinical particle radiotherapy at Lawrence Berkeley laboratory

1980 • 60 citations

Cancer Statistics, 1981

1981 • 59 citations

A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs.

1974 • 58 citations

A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus bcnu for treatment of malignant glioma after surgery; Preliminary results of an RTOG study

1983 • 58 citations

Sudden Myelopathy Secondary to Therapeutic Total-Body Hyperthermia after Spinal-Cord Irradiation

1981 • 55 citations

Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas

1976 • 54 citations

Controlled study with BCNU vs. CCNU as adjuvant chemotherapy following surgery plus radiotherapy for glioblastoma multiforme.

1979 • 53 citations

Survival of Irradiated Glia and Glioma Cells Studied with a New Cloning Technique

1980 • 53 citations

AUTOLOGOUS GLIOMA TRANSPLANTATION

1960 • 49 citations

Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.

1968 • 49 citations

Intra-arterial infusions of drugs and hyperosmotic solutions as ways of enhancing CNS chemotherapy.

1981 • 48 citations

Specificity of Lymphocyte-Mediated Cytotoxicity in Patients with Primary Intracranial Tumors

1978 • 48 citations

Clinical studies in malignant gliomas and their treatment with the nitrosoureas.

1976 • 47 citations

Dianhydrogalactitol and Radiation Therapy

1979 • 46 citations

Glioblastoma multiforme—A review of therapy

1974 • 43 citations

The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies.

1980 • 41 citations

Response of a rat brain tumor to fractionated therapy with low doses of BCNU and irradiation

1979 • 40 citations

Infratentorial glioblastoma: the role of neuraxis irradiation

1982 • 38 citations

Intracarotid BCNU (NSC-409962): a toxicity study in six rhesus monkeys.

1976 • 35 citations

Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content

1982 • 34 citations

Intracerebral delayed hypersensitivity reactions in glioblastoma multiforme patients

1977 • 33 citations

Immunotherapy of gliomas: a review.

1976 • 33 citations

Glioblastoma multiforme: Treatment by large dose fraction irradiation and metronidazole

1982 • 32 citations

Misonidazole and radiotherapy to treat malignant glioma: A phase II trial of the radiation therapy oncology group

1981 • 32 citations

Adjuvant Immunotherapy for Malignant Brain Tumors

1972 • 32 citations

How heterogeneous are gliomas?

1981 • 29 citations

Specific cellular immune responses in patients with malignant gliomas.

1979 • 28 citations

Fast neutron therapy for advanced brain tumors

1980 • 25 citations

Potentiation of radiation myelitis in rats by hyperthermia

1976 • 25 citations

Heterogeneous response to chemotherapy of human gliomas grown in nude mice and as clones in vitro.

1981 • 25 citations

Suggestive evidence for in vivo binding of specific anti-tumor antibodies of human melanomas

1975 • 21 citations

Hypoxic Cell Radiosensitizers in the Treatment of Malignant Brain Tumors

1980 • 20 citations

Soluble membrane antigens of brain tumors.I. Controlled testing for cell-mediated immune responses in a long surviving glioblastoma multiforme patient

1977 • 20 citations

Adjuvant Immunotherapy for Malignant Brain Tumors in Infants and Children

1975 • 19 citations

Cell-Mediated Cytotoxicity and Serum-Mediated Blocking: Evidence that Their Associated Determinants on Human Tumor Cells are Different

1978 • 19 citations

Work in progress: 252Cf neutron brachytherapy for hemispheric malignant glioma.

1982 • 18 citations

Glioblastoma multiforme: Treatment with radiation and trhodothyronine

1976 • 17 citations

Natural antibodies to cell‐surface antigens of human astrocytoma

1982 • 16 citations

High-dose radiation therapy with low-dose (pulsed) BCNU in malignant gliomas: An eastern cooperative oncology group (ECOG) report

1982 • 15 citations

Boron-neutron capture therapy in relation to immunotherapy

1978 • 15 citations

Potentials and limitations of a clonogenic cell assay for human brain tumors.

1981 • 13 citations

Detection of IgG on glioblastoma cell surfacein vivo

1978 • 13 citations

Efficacy of Neutrons in Radiotherapy

1981 • 12 citations

Dianhydrogalactitol and radiation therapy. Treatment of supratentorial glioma

1979 • 10 citations

Immunological aspects of experimental brain tumors (review).

1982 • 7 citations

Brain tumor therapy: Prospects for combining BCNU with conventional radiotherapy schedules

1981 • 7 citations

Boron neutron capture radiation therapy of cerebral glimoas: an analysis of the possible use of boron-loaded tumor-specific antibodies for the selective concentration of boron in gliomas

1982 • 6 citations

The use of cisplatinum for treatment of malignant glioma

1982 • 6 citations

Radiosensitizers: rationale and potential.

1981 • 4 citations

Humoral immune response in melanoma and glioma patients: A solubilized melanoma—membrane component as a tool for detecting circulating antibodies

1981 • 3 citations

[Anti-tumor antibodies in the blood of patients with gliomas].

1978 • 3 citations

Pharmacology of bromodeoxyuridine (NSC 38297) given by peripheral venous infusion

1982 • 2 citations

Primary intracranial gliomas: clinical studies and treatment regimens of the Brain Tumor Research Center, University of California, San Francisco, 1977-1979.

1981 • 1 citations