Nuclear Import of Hepatic Glucokinase Depends upon Glucokinase Regulatory Protein, whereas Export Is Due to a Nuclear Export Signal Sequence in Glucokinase

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

A short course in bacterial genetics : a laboratory manual and handbook for Escherichia coli and related bacteria

1992 • 2,517 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Movement of a karyophilic protein through the nuclear pores of oocytes.

1984 • 510 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

1996 • 326 citations

Translocation of RNA-coated gold particles through the nuclear pores of oocytes.

1988 • 292 citations

Nuclear Export Receptors: From Importin to Exportin

1997 • 282 citations

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

1994 • 279 citations

Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility

1986 • 251 citations

Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

1998 • 239 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats.

1988 • 224 citations

Rat glucokinase gene: structure and regulation by insulin.

1989 • 220 citations

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

1996 • 207 citations

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

1993 • 202 citations

A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6‐phosphate and fructose 1‐phosphate

1989 • 187 citations

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

1993 • 181 citations

The Amino Acid Sequence of Rat Liver Glucokinase Deduced from Cloned cDNA

1989 • 158 citations

Mammalian Glucokinase

1993 • 153 citations

Effects of Increased Glucokinase Gene Copy Number on Glucose Homeostasis and Hepatic Glucose Metabolism

1997 • 152 citations

Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin

1993 • 152 citations

Glucokinase Regulatory Protein May Interact With Glucokinase in the Hepatocyte Nucleus

1997 • 133 citations

Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver.

1987 • 133 citations

Molecular trafficking across the nuclear pore complex

1992 • 114 citations

The mechanism by which rat liver glucokinase is inhibited by the regulatory protein

1990 • 112 citations

Heterogeneous expression of glucokinase among pancreatic beta cells.

1992 • 109 citations

Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.

1986 • 107 citations

Expression of Human Hepatic Glucokinase in Transgenic Mice Liver Results in Decreased Glucose Levels and Reduced Body Weight

1997 • 99 citations

Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary Hepatocytes

1996 • 95 citations

The regulatory protein of liver glucokinase

1992 • 87 citations

Stimulation of glucose phosphorylation by fructose in isolated rat hepatocytes

1989 • 85 citations

Species and tissue distribution of the regulatory protein of glucokinase

1993 • 82 citations

Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.

1991 • 79 citations

Evidence for Glucokinase Translocation by Glucose in Rat Hepatocytes

1994 • 75 citations

Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation

1991 • 70 citations

The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation

1995 • 67 citations

Amino Acid Conservation in Animal Glucokinases

1996 • 61 citations

The cytokine interleukin‐5 (IL‐5) effects cotransport of its receptor subunits to the nucleus in vitro

1997 • 53 citations

Molecular Model of Human β-Cell Glucokinase Built by Analogy to the Crystal Structure of Yeast Hexokinase B

1994 • 42 citations

Effect of mutations on the sensitivity of human beta-cell glucokinase to liver regulatory protein

1996 • 42 citations

Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit

1996 • 41 citations

Evolution of the type II hexokinase gene by duplication and fusion of the glucokinase gene with conservation of its organization.

1993 • 34 citations

Functional Interaction between the N- and C-terminal Halves of Human Hexokinase II

1999 • 30 citations

Tissue and subcellular distribution of glucokinase in rat liver and their changes during fasting-refeeding

1995 • 26 citations

Alteration of Enzyme Function of the Type II Hexokinase C-terminal Half on Replacements of Restricted Regions by Corresponding Regions of Glucokinase

1996 • 8 citations