Effects of prostaglandin E2 on proliferation and apoptosis of epithelial ovarian cancer cells

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Aspirin use and risk of fatal cancer.

1993 • 884 citations

COX-2 is expressed in human pulmonary, colonic, and mammary tumors

2000 • 872 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Expression of cyclooxygenase-2 in human gastric carcinoma.

1997 • 829 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

1991 • 519 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Eicosanoids and the gastrointestinal tract

1995 • 426 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.

1999 • 405 citations

Cyclooxygenase-2 is overexpressed in human cervical cancer.

2001 • 330 citations

Reduced Risk of Large-Bowel Adenomas Among Aspirin Users

1993 • 301 citations

Cyclooxygenase-2 Overexpression Enhances Lymphatic Invasion and Metastasis in Human Gastric Carcinoma

1999 • 281 citations

Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility

1999 • 261 citations

Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells

1997 • 222 citations

Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors

2001 • 184 citations

Mycosis Fungoides Exhibits a Th1-Type Cell-Mediated Cytokine Profile Whereas Sezary Syndrome Express a Th2-Type Profile

1994 • 179 citations

Cytoplasmic induction and over‐expression of cyclooxygenase‐2 in human prostate cancer: implications for prevention and treatment

2000 • 177 citations

Prostaglandin Endoperoxide Synthase in Rat Ovarian Follicles: Content, Cellular Distribution, and Evidence for Hormonal Induction Preceding Ovulation*

1987 • 164 citations

Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: Evidence for growth suppression by inhibiting COX-2 expression

2000 • 158 citations

Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators

1995 • 157 citations

Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder

2001 • 149 citations

Cyclooxygenase-2 Expression and Prostaglandin E₂Synthesis Are Up-Regulated in Carcinomas of the Cervix: A Possible Autocrine/Paracrine Regulation of Neoplastic Cell Function via EP2/EP4 Receptors

2001 • 148 citations

Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats.

1996 • 117 citations

Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor‐β1

1999 • 105 citations

Increased production and release of prostaglandin-E2 by human granulosa cells from polycystic ovaries

1996 • 29 citations

The Role of Cytokines in the Production of Prostacyclin and Thromboxane in Human Mononuclear Cells

1994 • 27 citations