The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

A regulatory link between ER-associated protein degradation and the unfolded-protein response.

2000 • 459 citations

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

1995 • 402 citations

The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 • 391 citations

Role of Cue1p in Ubiquitination and Degradation at the ER Surface

1997 • 386 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control

2000 • 338 citations

Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation

2000 • 332 citations

Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum

2000 • 331 citations

The Requirement for Molecular Chaperones during Endoplasmic Reticulum-associated Protein Degradation Demonstrates That Protein Export and Import Are Mechanistically Distinct

1999 • 286 citations

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

1999 • 281 citations

Protein disulfide isomerase: The multifunctional redox chaperone of the endoplasmic reticulum

1999 • 272 citations

The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase.

1995 • 268 citations

Oligosaccharide Modification in the Early Secretory Pathway Directs the Selection of a Misfolded Glycoprotein for Degradation by the Proteasome

1999 • 235 citations

Activation of NF‐κB by ER stress requires both Ca²⁺ and reactive oxygen intermediates as messengers

1996 • 215 citations

Degradation of Proteins from the ER of S. cerevisiae Requires an Intact Unfolded Protein Response Pathway

2000 • 185 citations

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

2000 • 170 citations

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention.

1996 • 168 citations

The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

1993 • 163 citations

Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

2000 • 147 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 147 citations

Processing by Endoplasmic Reticulum Mannosidases Partitions a Secretion-impaired Glycoprotein into Distinct Disposal Pathways

2000 • 120 citations

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes

1999 • 112 citations

Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation

2000 • 92 citations

Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin

1997 • 90 citations

Glucosidase and Mannosidase Inhibitors Mediate Increased Secretion of Mutant α1 Antitrypsin Z

2000 • 84 citations

Protein folding in a specialized compartment: the endoplasmic reticulum

1999 • 78 citations

Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome.

1999 • 63 citations

Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme.

1994 • 56 citations

Expression of a Gene for Cyclophilin Which Contains an Amino-Terminal Endoplasmic Reticulum-Targeting Signal

1999 • 41 citations

Calnexin family members as modulators of genetic diseases

1999 • 37 citations

Oligosaccharide Trimming Plays a Role in the Endoplasmic Reticulum-Associated Degradation of Tyrosinase

2000 • 36 citations

Unfolded protein response-induced BiP/Kar2p production protects cell growth against accumulation of misfolded protein aggregates in the yeast endoplasmic reticulum

1999 • 25 citations

Structure and Folding of Nascent Polypeptide Chains during Protein Translocation in the Endoplasmic Reticulum

1997 • 18 citations

Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides.

1992 • 7 citations

Molecular chaperone systems in the endoplasmic reticulum

2001 • 3 citations