Effect of cross-linking on the chaperone-like function of alpha crystallin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.

1982 • 792 citations

αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain

1989 • 546 citations

αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues

1989 • 538 citations

Molecular and Cellular Biology of the Eye Lens.

1981 • 447 citations

Expression of the murine alpha B-crystallin gene is not restricted to the lens.

1989 • 377 citations

Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.

1993 • 375 citations

Cataract: Biochemistry, Epidemiology and Pharmacology

1991 • 365 citations

Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions.

1992 • 259 citations

Molecular and cellular biology of the eye lens

1981 • 256 citations

alpha A-crystallin is expressed in non-ocular tissues

1992 • 251 citations

High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.

1991 • 250 citations

A quantitative dot-immunobinding assay for proteins using nitrocellulose membrane filters.

1984 • 249 citations

Immunoreactive αA crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method

1991 • 220 citations

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

1991 • 196 citations

Post-translational modifications of water-soluble human lens crystallins from young adults.

1994 • 177 citations

The Ocular Lens. Structure, Function, and Pathology

1985 • 162 citations

Stepwise degradations and deamidation of the eye lens protein α-crystallin in ageing

1975 • 141 citations

Protein-thiol mixed disulfides in human lens

1992 • 125 citations

The Ocular lens : structure, function, and pathology

1985 • 119 citations

Nonenzymatic glycosylation of bovine lens crystallins. Effect of aging.

1981 • 119 citations

The C-terminal region of α-crystallin: involvement in protection against heat-induced denaturation

1993 • 118 citations

α-Crystallin, a Molecular Chaperone, Forms a Stable Complex with Carbonic Anhydrase upon Heat Denaturation

1993 • 116 citations

Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins

1986 • 112 citations

The role of ascorbic acid in senile cataract.

1985 • 105 citations

Spatial and temporal mapping of the age-related changes in human lens crystallins

1985 • 98 citations

alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.

1993 • 96 citations

The precipitation and cross-linking of lens crystallins by ascorbic acid

1988 • 93 citations

The ability of lens alpha crystallin to protect against heat-induced aggregation is age-dependent

1992 • 89 citations

Mechanism of cataract production by 3-β(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: An inhibitor of cholesterol biosynthesis

1979 • 88 citations

The role of protein-thiol mixed disulfides in cataractogenesis

1990 • 85 citations

Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses.

1976 • 84 citations

Characterization of the α-γ and α-β Complex: Evidence for an In Vivo Functional Role of α-Crystallin as a Molecular Chaperone

1994 • 80 citations

Cardiac alpha-crystallin

1990 • 79 citations

Lens protein composition, glycation and high molecular weight aggregation in aging rats.

1987 • 77 citations

Protein distribution patterns in concentric layers from single bovine lenses: changes with development and ageing

1988 • 67 citations

Quantitative Analysis of Cystine, Methionine, Lysine, and Nine Other Amino Acids by a Single Oxidation-4 Hour Hydrolysis Method

1987 • 53 citations

Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.

1994 • 43 citations

Molecular chaperone properties of the high molecular weight aggregate from aged lens

1994 • 35 citations

The effects of isolation buffers on the properties of α-crystallin

1992 • 34 citations

The Quaternary Structure of Bovine α‐Crystallin

1980 • 32 citations

Site Selectivity in the Glycation of αA-Crystallin and αB-Crystallins by Glucose

1994 • 28 citations

Solubilization of the lens water-insoluble fraction by sonication

1986 • 27 citations

Increase of non-disulphide cross-links during progress of nuclear cataract

1978 • 25 citations

Identification of the major components of the high molecular weight crystalline from old human lenses

1994 • 25 citations

Origin of urea-soluble protein in the selenite cataract. Role of beta-crystallin proteolysis and calpain II.

1987 • 19 citations

Regulation of the Interphotoreceptor Retinoid-binding Protein Content of the Retina by Vitamin A

1993 • 14 citations

Preferential interaction of alpha crystallin with denatured forms of gamma crystallin.

1994 • 11 citations

The effect of urea on the aggregate state and elastase inhibitor activity of the water-insoluble fraction from bovine and human lens

1992 • 9 citations

Chemical Modification of Alpha Crystallin

1993 • 7 citations